Clinical response and changes in nitrogen balance, body weight, plasma proteins, and hemoglobin following tube feeding in cancer cachexia

Pareira, Morton D.; Conrad, Elke; Hicks, William M.; Elman, Robert

doi:10.1002/1097-0142(1955)8:4<803::aid-cncr2820080427>3.0.co;2-6

Cited by 40 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Changes in metabolism and altered energy requirements have been documented in patients with cancer as early as the 1950s, 1 yet it was not until the 1970s that the multifaceted nature of CAC (also referred to as cancer cachexia) was appreciated. 2,3 While early studies suggested that CAC was the result of tumor-driven anorexia alone, 4 it is now established that CAC is not solely the result of decreased food intake; other contributing factors such as malabsorption and altered metabolism play a role as well. 2,3 In the early 2000s, increased emphasis was placed on consolidating clinical and basic research findings to develop guidelines for defining, staging, and treating CAC.…”

Section: Introduction: the Clinical Problem – Cacmentioning

confidence: 99%

The role of adipose tissue in cancer-associated cachexia

Vaitkus

Celi

2016

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

Adipose tissue (fat) is a heterogeneous organ, both in function and histology, distributed throughout the body. White adipose tissue, responsible for energy storage and more recently found to have endocrine and inflammation-modulatory activities, was historically thought to be the only type of fat present in adult humans. The recent demonstration of functional brown adipose tissue in adults, which is highly metabolic, shifted this paradigm. Additionally, recent studies demonstrate the ability of white adipose tissue to be induced toward the brown adipose phenotype – “beige” or “brite” adipose tissue – in a process referred to as “browning.” While these adipose tissue depots are under investigation in the context of obesity, new evidence suggests a maladaptive role in other metabolic disturbances including cancer-associated cachexia, which is the topic of this review. This syndrome is multifactorial in nature and is an independent factor associated with poor prognosis. Here, we review the contributions of all three adipose depots – white, brown, and beige – to the development and progression of cancer-associated cachexia. Specifically, we focus on the local and systemic processes involving these adipose tissues that lead to increased energy expenditure and sustained negative energy balance. We highlight key findings from both animal and human studies and discuss areas within the field that need further exploration. Impact statement Cancer-associated cachexia (CAC) is a complex, multifactorial syndrome that negatively impacts patient quality of live and prognosis. This work reviews a component of CAC that lacks prior discussion: adipose tissue contributions. Uniquely, it discusses all three types of adipose tissue, white, beige, and brown, their interactions, and their contributions to the development and progression of CAC. Summarizing key bench and clinical studies, it provides information that will be useful to both basic and clinical researchers in designing experiments, studies, and clinical trials.

show abstract

Section: Introduction: the Clinical Problem – Cacmentioning

confidence: 99%

The role of adipose tissue in cancer-associated cachexia

Vaitkus

Celi

2016

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

show abstract

“…There is conflicting evidence on the use of these methods in cancer patients. Pareira, Conrad, Hicks & Elman (1955) suggest that it may be beneficial in that some patients may gain weight and begin to eat normally, on the other hand, Terepka & Waterhouse (1956) have indicated that there may be acceleration of the disease. This, however, was a small study with only six patients.…”

Section: '978mentioning

confidence: 99%

Nutritional Support in Malignant disease

Calman

1978

Proc. Nutr. Soc.

View full text Add to dashboard Cite

The patient with cancer has multiple metabolic and nutritional abnormalities. The indications and methods of nutritional support required may therefore vary considerably from patient to patient. Currently many techniques are available for the administration of nutritional support. Rather than review each of these in detail it is considered more appropriate to pose specific questions in relation to nutrition and cancer.

show abstract

Transanastomotic Tube Feeding Following Gastric Surgery

Pareira¹,

Heeb²

1958

Arch Surg

View full text Add to dashboard Cite

Clinical response and changes in nitrogen balance, body weight, plasma proteins, and hemoglobin following tube feeding in cancer cachexia

Cited by 40 publications

References 10 publications

The role of adipose tissue in cancer-associated cachexia

The role of adipose tissue in cancer-associated cachexia

Nutritional Support in Malignant disease

Transanastomotic Tube Feeding Following Gastric Surgery

Contact Info

Product

Resources

About