Clinical response of myelodysplastic syndromes patients to treatment with coenzyme Q10

Galili, Naomi; Sechman, Eric V.; Černý, Jan; Mehdi, Murtaza; Mumtaz, Muhammad Ali; Westervelt, Peter; Maguire, Jessica; Raza, Azra

doi:10.1016/j.leukres.2006.04.009

Cited by 6 publications

(5 citation statements)

References 10 publications

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“…Galili et al demonstrated a clinical benefit of high dose CoQ10 in some MDS patients. 12 Likewise, combined treatment with CoQ10 and carnitine ameliorated anemia and RBC-transfusion-dependence in 6 out of 28 (21.4%) in our patient group. This improvement is noteworthy, as generally, low-risk MDS patients have minimal treatment options once they do not respond to ESAs.…”

Section: )supporting

confidence: 55%

“…10,11 Further support for the role of impairment of mitochondrial function in the pathogenesis of the disease as well as a possible novel therapeutic approach was seen in a pilot study on low-risk MDS patients in which treatment with CoQ10 resulted in about 25% hematologic response and even cytogenetic response in some of the patients. 12 L-carnitine is required to transport fatty acids from the cytosol to the mitochondrial during the breakdown of lipids. It has also been used to improve mitochondrial function and has been shown to have a synergistic effect when combined with coenzyme Q10 in various medical conditions.…”

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confidence: 99%

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Perpheral Blood Cell Mitochondrial Dysfunction in Myelodysplastic Syndromecan Be Improved by a Combination of Coenzyme Q10 and Carnitine

Filanovsky

Haran

Mirkin³

et al. 2020

Mediterr J Hematol Infect Dis

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Structural mitochondrial abnormalities as well as genetic aberrations in mitochondrial proteins have been known in Myelodysplastic syndrome (MDS) , yet there is currently little data regarding the metabolic properties and energy production of MDS cells. In the current study we used state-of-the-art methods to assess OXPHOS in peripheral blood cells obtained from MDS patients and healthy controls We then assessed the effect of food supplements- Coenzyme Q10 and carnitine on mitochondrial function and hematological response .We show here for the first time that in low risk MDS there is a significant impairment of mitochondrial respiration in peripheral blood cells and this can be improved with food supplements. We also show that such myelodysplastic syndrome, mitochondria, oxidative phosphorylation, coenzyme Q10, seahorse XF analyzer. supplements lead to improvement in cytopenia's and quality of life.

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Section: )supporting

confidence: 55%

mentioning

confidence: 99%

Perpheral Blood Cell Mitochondrial Dysfunction in Myelodysplastic Syndromecan Be Improved by a Combination of Coenzyme Q10 and Carnitine

Filanovsky

Haran

Mirkin³

et al. 2020

Mediterr J Hematol Infect Dis

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“…Similar approaches may benefit hematologic diseases like MDS. Indeed, initial research in this area has shown some promise (Greenberg et al 2002;Galili et al 2007). While modulation of the cell cycle is a common therapeutic target in MDS (Corey et al 2007), addition of agents that strike at the dysfunctional mitochondria of cells arising from surviving dysplastic clones might be beneficial.…”

Section: Cell Cycle Regulation Mitochondrial Biogenesis and Differementioning

confidence: 99%

Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis

Sankaran

Orkin²,

Walkley³

2008

Genes Dev.

122

118

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Regulation of the cell cycle is intimately linked to erythroid differentiation, yet how these processes are coupled is not well understood. To gain insight into this coordinate regulation, we examined the role that the retinoblastoma protein (Rb), a central regulator of the cell cycle, plays in erythropoiesis. We found that Rb serves a cell-intrinsic role and its absence causes ineffective erythropoiesis, with a differentiation block at the transition from early to late erythroblasts. Unexpectedly, in addition to a failure to properly exit the cell cycle, mitochondrial biogenesis fails to be up-regulated concomitantly, contributing to this differentiation block. The link between erythropoiesis and mitochondrial function was validated by inhibition of mitochondrial biogenesis. Erythropoiesis in the absence of Rb resembles the human myelodysplastic syndromes, where defects in cell cycle regulation and mitochondrial function frequently occur. Our work demonstrates how these seemingly disparate pathways play a role in coordinately regulating cellular differentiation.

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“…Coenzyme Q10 (CoQ10): Some evidence suggests the efficacy of CoQ10, at a dosage of 1200 mg/daily, in causing not only hematological but even cytogenetic remissions [ 9 ].…”

Section: Myeloid Malignanciesmentioning

confidence: 99%

Integrative Hematology: State of the Art

Andreazzoli

Bonucci²

2023

IJMS

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Blood cancers are a group of diseases with thus far frequently poor prognosis. Although many new drugs, including target therapies, have been developed in recent years, there is still a need to expand our therapeutic armamentarium to better deal with these diseases. Integrative hematology was conceived as a discipline that enriches the patient’s therapeutic possibilities with the use of supplements, vitamins and a nutritional approach aiming at improving the response to therapies and the clinical outcome. We will analyze the substances that have proved most useful in preclinical and clinical studies in some of the most frequent blood diseases or in those where these studies are more numerous; the importance of the nutritional approach and the role of the intestinal microbiota will also be emphasized.

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Clinical response of myelodysplastic syndromes patients to treatment with coenzyme Q10

Cited by 6 publications

References 10 publications

Perpheral Blood Cell Mitochondrial Dysfunction in Myelodysplastic Syndromecan Be Improved by a Combination of Coenzyme Q10 and Carnitine

Perpheral Blood Cell Mitochondrial Dysfunction in Myelodysplastic Syndromecan Be Improved by a Combination of Coenzyme Q10 and Carnitine

Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis

Integrative Hematology: State of the Art

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