2018
DOI: 10.1111/dme.13631
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Clinical risk factors for depressive syndrome in Type 2 diabetes: the Fremantle Diabetes Study

Abstract: Risk factors for depressive syndrome can be identified early after the onset of Type 2 diabetes. The early presence of depressive symptoms or its treatment and/or history of depression are likely indicators of vulnerability. Early risk stratification for late depressive syndrome is feasible in people with Type 2 diabetes and could assist with depression treatment or prevention.

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Cited by 9 publications
(12 citation statements)
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“…Screening T2D patients for neuropsychological multimorbidity such as depression and cognitive decline is important because they have been shown to reduce the capability of the individual to perform effective diabetes self-care. Simple screening tests such as the Patient Health Questionnaire-9 (PHQ-9)82 and the Montreal Cognitive Assessment (MoCA)83 can be administered in clinic settings and have been previously validated in the diabetes population.…”
Section: Discussionmentioning
confidence: 99%
“…Screening T2D patients for neuropsychological multimorbidity such as depression and cognitive decline is important because they have been shown to reduce the capability of the individual to perform effective diabetes self-care. Simple screening tests such as the Patient Health Questionnaire-9 (PHQ-9)82 and the Montreal Cognitive Assessment (MoCA)83 can be administered in clinic settings and have been previously validated in the diabetes population.…”
Section: Discussionmentioning
confidence: 99%
“…The ability of carbohydrates to increase the uptake of circulating tryptophan into the brain depends on its ability to promote the secretion of insulin [63]; thus, by consuming more carbohydrates, a greater secretion of insulin will ensue, plasma levels of LNAA will decrease, and the supply of tryptophan to the brain will increase [63]. Moreover, by consuming SSBs, and the side effects that follow, including obesity and type 2 diabetes (T2D), researchers have found a bi-directional relationship between obesity or T2D and depression [64][65][66].…”
Section: Discussionmentioning
confidence: 99%
“…Persistent hyperglycemia can lead to the synthesis of reactive oxygen species that exert neurotoxic effects on the brain 41 . The consumption of added sugar can cause insulin resistance, which is also a known risk factor for depression 42 and suicidal behavior 43 .…”
Section: Discussionmentioning
confidence: 99%