Clinical severity and prognosis of hand eczema

Hald, Marianne; Agner, Tove; Blands, Jette; Veien, Niels K.; Laurberg, Grete; Avnstorp, Christian; Menné, Torkil; Kaaber, K; Kristensen, Berit; Kristensen, Ove; Andersen, Klaus Ejner; Paulsen, Evy; Thormann, Jens; Sommerlund, Mette; Nielsen, N.H.; Johansen, Jeanne Duus

doi:10.1111/j.1365-2133.2009.09139.x

Cited by 65 publications

(97 citation statements)

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“…The median age of the cohort was 41 years (age range 18-84 years) at baseline, 65.2% (« = 521) were women and 34.8% (« = 278) were men (6). The present clinical severity, assessed by the patients using the self-administered photographic guide, was reported as severe or very severe by 25.3% of the patients, 35.0% had moderate symptoms, 33.1% had mild symptoms and 6.7% reported being free of hand eczema (6). In all, 697 patients (response rate il.2%) completed all 10 questions on the DLQI questionnaire at baseline; 571 individuals completed the DLQI at follow-up.…”

Section: Resultsmentioning

confidence: 99%

“…Mutations in DSG4 (encoding desmoglein 4) have been found to be responsible for LAHl (5). Kazantseva et al (6) reported deletion mutations in LIPH leading to LAH2. Pasternack et al (7) reported disruption of LPAR6 in families affected with LAH3.…”

Section: Discussionmentioning

confidence: 99%

“…The DLQI questions were included in both the baseline and the follow-up questionnaire (permission granted). A detailed description of the study cohort including a dropout analysis of the non-respondents has been published previously (6).…”

Section: Methodsmentioning

confidence: 99%

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Quality of Life in a Population of Patients With Hand Eczema: A Six-month Follow-up Study

Hald¹,

Agner²,

Blands³

et al. 2011

Acta Derm Venerol

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Hand eczema is a disease with a potentially profound effect on an individual's life in terms of daily ftmctioning and interpersonal relationships. Accordingly, methods for measuring health-related quality of life (QoL) are increasingly used to evaluate the effect of various treatments.In studies of skin diseases the most widely used dermatology-specific questionnaire is the Dermatology Life Quality Index (DLQI) (1). The various scales applied, in the context of skin diseases, were evaluated by Both et al.(2). Their paper, which evaluated the interpretability of the DLQI, revealed a need for reports concerning the minimal change of score that is relevant to the patients. A similar need was expressed in a review by Basra et al. (3).The aim of the present study was to explore potential factors related to a low health-related QoL among patients with hand eczema and to examine the responsiveness of the DLQI score to clinical changes. MATERIALS AND METHODSThe study involved six private clinics and three outpatient clinics at university hospitals. The study population comprised consecutive hand eczema patients, aged 18 years or older, referred with present hand eczema to one of the clinics and enrolled during the period January 2006 to February 2007. At the first consultation the clinical severity of hand eczema was assessed by the patients using a self-administered photographic guide (4). All patients were patch-tested with the European Baseline Series (5). In the case of exposure to other known allergens, additional patch tests were applied, for example the hairdressing series in hairdressers. Patients completed a self-administered questionnaire at the time of patch testing.Approximately 6 months later (median 7 months; range 4-15 months) patients received a questionnaire package by post, which included a follow-up questionnaire and a selfadministered photographic guide. The DLQI questions were included in both the baseline and the follow-up questionnaire (permission granted). A detailed description of the study cohort including a dropout analysis of the non-respondents has been published previously (6).The DLQI is a 10-item questionnaire covering six aspects of daily life experienced during the past week. It is calculated by summing the score, of each question, with a maximum score of 30 and a minimum score of 0; the higher the score, the greater the impairment in QoL (1). In this study cut-off points were made dichotomizing the DLQI total score into low QoL corresponding to the one-third of the cohort with the highest score (score 7-30) and a score < 7 identifying those with moderate to high QoL at baseline. By subtracting the DLQI score, the course from baseline to follow-up was defined as improved or unchanged/diminished QoL.The data from the DLQI questionnaires were analysed by non-parametric statistics, as the DLQI score of the cohort was not normally distributed (Kolmogorov-Smimov test, p < 0.001 ).The Wilcoxon signed-rank test was used to compare paired data, and the Mann-Whitney test or Kruskal-Wallis test wa...

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Quality of Life in a Population of Patients With Hand Eczema: A Six-month Follow-up Study

Hald¹,

Agner²,

Blands³

et al. 2011

Acta Derm Venerol

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“…Prompt treatment is recommended because hand eczema has a tendency to become chronic, in which case resistance to topical treatment is common. 19 Current treatment strategies are largely based on clinical experience and may differ from country to country. 7,8,20 Few therapies have been evaluated in randomized, controlled trials, 21 and the trials that have been conducted typically have not distinguished types of eczema.…”

Section: Hand Eczemamentioning

confidence: 99%

Hand Eczema

2012

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“…In patients with occupational hand eczema, only 28-40% reported total recovery [5,6]. Poor prognosis and persistence of hand eczema have been found to be correlated with severe initial disease and its duration before diagnosis [6,7]. In European countries, skin diseases are among the top three in the list of occupational diseases [8].…”

Section: Introductionmentioning

confidence: 99%

Effects of Systematic Patient Education in Skin Care and Protection in a Hand Eczema Clinic

Corti

Stirnimann²,

Borradori³

et al. 2014

Dermatology

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Background: Hand eczema has a high impact on patients' quality of life. The treatment focuses on improving skin barrier function. Objectives: To evaluate the effects and acceptance of a novel educational program for patients with hand eczema. Methods: Retrospectively, the records of 36 patients who attended the prevention program and follow-up visits were analyzed. Physician global assessment (PGA) scores, acceptance and behavioral changes were assessed. Results: In 67% of patients, an improvement of the hand eczema could be attributed to the effects of our educational program. The mean PGA score significantly decreased from 3 before education to 2.2 during follow-up. Behavioral changes in both skin care and protection were reported in 81 and 86%, respectively. Conclusions: Our educational program had a positive effect on clinical outcome as well as adherence to skin care and protection measures. Its integration in a hand eczema clinic was feasible and well accepted by the patients.

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Clinical severity and prognosis of hand eczema

Abstract: Overall, the disease had improved 6 months after the dermatological examination: nevertheless, many patients continued to have significant symptoms. Dermatologists should pay special attention to patients with frequent eruptions and to unskilled workers.

Cited by 65 publications

References 34 publications

Quality of Life in a Population of Patients With Hand Eczema: A Six-month Follow-up Study

Quality of Life in a Population of Patients With Hand Eczema: A Six-month Follow-up Study

Hand Eczema

Effects of Systematic Patient Education in Skin Care and Protection in a Hand Eczema Clinic

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