Clinical Significance of Analysis of Vitamin D Status in Various Diseases

Abstract

Vitamin D plays a role not only in the proper functioning of the skeletal system and the calcium-phosphate equilibrium, but also in the immune system, the cardiovascular system and the growth and division of cells. Although numerous studies have reported on the analysis of vitamin D status in various groups of patients, the clinical significance of measurements of vitamin D forms and metabolites remains ambiguous. This article reviews the reports analyzing the status of vitamin D in various chronic states. Particular attention is given to factors affecting measurement of vitamin D forms and metabolites. Relevant papers published during recent years were identified by an extensive PubMed search using appropriate keywords. Measurement of vitamin D status proved to be a useful tool in diagnosis and progression of metabolic syndrome, neurological disorders and cancer. High performance liquid chromatography coupled with tandem mass spectrometry has become the preferred method for analyzing the various forms and metabolites of vitamin D in biological fluids. Factors influencing vitamin D concentration, including socio-demographic and biochemical factors as well as the genetic polymorphism of the vitamin D receptor, along with vitamin D transporters and enzymes participating in vitamin D metabolism should be considered as potential confounders of the interpretation of plasma total 25(OH)D concentrations.

Trend research of vitamin D receptor: Bibliometric analysis

“…7 Moreover, recent studies have highlighted the importance of the analysis of vitamin D serum levels and its metabolites in multiple diseases. 8,9 Bibliometric research is a valuable method to analyze qualitatively and quantitatively the publications related to a particular subject. The method assists in identifying novel and emerging areas of research and it is widely used in the medical research field.…”

Impact of Vitamin D Supplementation on Inflammatory Markers’ Levels in Obese Patients

“…Despite many reports regarding the abovementioned markers and therapies, the primary outcomes remain the most important issues for clinical practitioners. There are many findings implying the efficacy of vitamin D supplementation in diseases and processes related to inflammation (reviewed in [103]). Levels of vitamin D higher than 50 mmol/L were connected with reduced risk of prostate and colorectal cancer by 30-50% [104,105].…”

Key mechanisms of the relationship between vitamin D and cardiovascular disease

“…РААС играет значимую роль в патофизио логии АГ, влияя на реабсорбцию натрия в почках, а также на реактивность сосудов. Доказано, что FGF23 стимулирует РААС, подавляя экспрессию ангиотензинпревращающего фермента 2 в почках, что может приводить к повышению активации рецепторов к ангиотензину I, а также к развитию гипер-свободных радикалов, оказывает противовоспалительное действие, тем самым влияя на стабилизацию атеросклеротических бляшек [17]. Krishna SM (2019) сообщает, что дефицит витамина D вносит вклад в развитие и прогрессирование многих ССЗ, что также связано с гиподинамией и ограничением воздействия солнечного света.…”