Clinical Significance of Combined Use of Macrophage Colony-Stimulating Factor and Squamous Cell Carcinoma Antigen as a Selective Diagnostic Marker for Squamous Cell Carcinoma Arising in Mature Cystic Teratoma of the Ovary

Suzuki, Mitsuaki; Tamura, Natsuko; Kobayashi, Hiroshi; Ohwada, Michitaka; Terao, Toshihiko; Sato, Ikuo

doi:10.1006/gyno.2000.5784

Cited by 29 publications

(32 citation statements)

References 14 publications

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“…Therefore, the M-CSF serum concentration is used as a tumor marker in these malignancies. Also, marked immunohistochemical staining for M-CSF in the cytoplasm of epithelial cancer cells and in stromal macrophages of epithelial ovarian cancer has been observed, so that the elevated serum levels in patients with malignant squamous cell carcinomas could be due to overproduction of M-CSF in these cancer cells [4,19]. To the best of our knowledge, the M-CSF serum concentration has not yet been investigated in patients with SCCHN.…”

Section: Discussionmentioning

confidence: 96%

“…Therefore, M-CSF is considered a tumor marker in these malignancies [1][2][3]. Elevated M-CSF serum levels were also observed in patients with squamous cell carcinoma derived from mature cystic teratoma [4]. M-CSF is also known as CSF-1 and belongs to the family of colonystimulating factors, which are glycoproteins that stimulate the proliferation and differentiation of progenitor cells into mature cells in the hematopoietic pathway [5].…”

Section: Introductionmentioning

confidence: 99%

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Macrophage Colony-Stimulating Factor as a Tumor Marker for Squamous Cell Carcinoma of the Head and Neck

Kuropkat¹,

Dünne²,

Plehn³

et al. 2003

Tumor Biol

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It has been demonstrated that in patients with epithelial ovarian cancer and malignant germ cell tumors of the ovary, macrophage colony-stimulating factor (M-CSF) is significantly elevated in the serum compared to healthy individuals. Therefore, M-CSF has been suggested as a tumor marker in these malignancies. In the present study, the tumor marker potential of the serum M-CSF concentration in patients with squamous cell carcinomas of the head and neck (SCCHN) was investigated. The serum M-CSF concentration was determined by a quantitative sandwich enzyme immunoassay in 59 patients suffering from SCCHN and 59 healthy controls. A significant difference in the mean serum concentration of M-CSF between the patients with SCCHN and the control group was found (p = 0.002). The M-CSF serum concentration correlated neither with the stage of disease nor with histopathological grading, and no correlation with serum C-reactive protein was found. The serum M-CSF concentration could be of interest as a tumor marker in SCCHN.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Macrophage Colony-Stimulating Factor as a Tumor Marker for Squamous Cell Carcinoma of the Head and Neck

Kuropkat¹,

Dünne²,

Plehn³

et al. 2003

Tumor Biol

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“…Numerous data on proposed biomarkers were considered too preliminary, being introduced at the early phases of development/research. Macrophage-colony stimulating factor/M-CSF was identified as a Model marker for early detection of cancer because several clinical studies compared its sensitivity and specificity with traditional markers for a number of cancers [1,[30][31][32][33][34]45].…”

Section: Methodsmentioning

confidence: 99%

“…• Marker possesses predictive values: its levels in patient biorepositories (e.g., serum/blood, urine, and saliva or tissue specimen) would correlate with the tumor stage. • Superior sensitivity and specificity to traditional markers: comparison of data on specificity and sensitivity of the marker with traditional/conventional markers; diagrams on receiver-operating characteristic (ROC) curves would demonstrate its superior quality to traditional markers (e.g., CA-19-9, CA-125, or CEA) [14][15][16][17][30][31][32][33][34]45,Khatami, personal communications];…”

Section: Methodsmentioning

confidence: 99%

“…Macrophage-colony stimulating factor (M-CSF) is an inflammatory mediator, a cytokine, with pleiotropic properties and diverse biological/immunological profiles in inflammatory conditions and cancer [15,19,20,[30][31][32][33][34]45]. Recruited macrophages can proliferate locally in chronic inflammatory diseases (e.g., glomerulonephritis, allograft rejection, pancreatitis, arthritis, conjunctivitis) or in many cancers [1,15,20,32,37,41].…”

Section: Model Presentationmentioning

confidence: 99%

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Standardizing cancer biomarkers criteria: data elements as a foundation for a database. Inflammatory mediator/M-CSF as model marker

Khatami

2007

Cell Biochem Biophys

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The purpose of this position article was to design a set of criteria (data elements) for a wide range of cancer biomarkers (CBs) in an attempt to standardize biomarkers features through a common language as a foundation for a database. Data elements are described as a set of generic criteria, which should characterize nearly all biomarkers introduced in the literature. Data elements were extracted from the review of prominent features that biomarkers represent within various categories. The extracted characteristics of biomarkers produced a short list of shared and unique generic features such as biological nature and history; stage/phase of study; sensitivity and specificity; modes of action; risk assessment; validation status; technology, and recommendation status for diversified biomarkers. To tailor data elements on specific markers, a cytokine, such as macrophage-colony stimulating factor (M-CSF), which has been proposed as a 'potentially suitable biomarker' for diagnosis of ovarian, lung, breast, pancreatic, and colorectal cancers, was selected as a Model biomarker. Small scale clinical studies suggested the superior usefulness of M-CSF compared with traditional markers for cancer detection. A key criterion for selecting Model marker and tailoring data elements for detection of cancer was the comparison of data on its specificity and sensitivity with traditional markers. The design of data elements for standardizing CBs criteria is considered a Research Tool and a foundation for developing a comprehensive CBs database useful for oncology researchers for a wide range of biomarkers. Validation, integration and proper packaging, data visualization and recommendation of suitability of CBs, by a panel of experts, for technology development are important challenging next steps toward developing a reliable database, which would allow professionals to effectively retrieve and study integrated information on potentially useful markers; identify important knowledge gaps and limitations of data; and assess state of technologies and commercialization of markers at a point of need. Appropriate use of integrated information on biomarkers in clinical practices would eventually account for more cost-effective characteristics of an individual's state of health.

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Malignant transformation in mature cystic teratoma of the ovary: report of five cases and review of the literature

Bal

Mohan

Singh

et al. 2006

Arch Gynecol Obstet

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The incidence of malignant transformation in mature cystic teratoma (MCT) of the ovary is less than 2% as reported in gynaecological and pathological literature. Here we present a series of five patients, who developed malignant transformation in MCT of the ovary, over a 6-year period (1999-2004). The morphological and clinico-pathological features of malignant transformation in MCT of the ovary are discussed.

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Clinical Significance of Combined Use of Macrophage Colony-Stimulating Factor and Squamous Cell Carcinoma Antigen as a Selective Diagnostic Marker for Squamous Cell Carcinoma Arising in Mature Cystic Teratoma of the Ovary

Cited by 29 publications

References 14 publications

Macrophage Colony-Stimulating Factor as a Tumor Marker for Squamous Cell Carcinoma of the Head and Neck

Macrophage Colony-Stimulating Factor as a Tumor Marker for Squamous Cell Carcinoma of the Head and Neck

Standardizing cancer biomarkers criteria: data elements as a foundation for a database. Inflammatory mediator/M-CSF as model marker

Malignant transformation in mature cystic teratoma of the ovary: report of five cases and review of the literature

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