Clinical Significance of Cyclophosphamide-induced Cardiotoxicity

Very acute cardiac toxicity during BEAC chemotherapy in non-Hodgkin's lymphoma patients undergoing autologous stem cell transplantation

“…20 However, it is well known that BNP is primarily released from the ventricles and reflects filling pressure of the left ventricle and ANP is released in response to atrial distension. 21 This is well in line with our finding that dilatation of cardiac chambers correlated with the increase in NT-proBNP.…”

“…The whole blood was centrifuged and plasma immediately frozen and stored at À701C. Circulating NT-proBNP (antiserum to NT-proBNP [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] ) and NT-proANP (antiserum to NT-proANP 46-79 ) concentrations were determined by radioimmunoassays as previously described. Molecular heterogeneity has a major impact on the measurement of circulating N-terminal fragments of A-and B-type natriuretic peptides.…”

Cardiovascular Toxicity and Monitoring Methods in Oncologic Patients

“…Moreover, one of the risk factors for developing cardiac side effects is a previous treatment with anthracyclines or a prior chest irradiation (Gottdiener et al 1981). Furthermore, exposure to erythropoiesis-stimulating agents as well as longer-lasting central venous catheter seems to increase the risk for cardiac side effects (Taniguchi 2005).…”

“…Other severe and dose-limiting side effects include thromboembolic events, which occurred with a relatively high incidence of 18 % within 100 days of initial drug application (Taniguchi 2005). The pathogenesis of cisplatin-associated vascular side effects could include hypomagnesaemia, increased von Willebrand factor and enothelial cell damage due to an increase of procoagulant endothelial microparticles and platelet activation.…”

Cardiovascular Side-Effects of Modern Cancer Therapy

“…In addition, patients who previously received anthracyclines or underwent chest irradiation are more likely to suffer from CPA-induced cardiotoxicity. 22 Cisplatin Cisplatin (CDDP) is a chemotherapeutic agent also used widely in the treatment of solid tumors, including lung, gastrointestinal, urinary, gynecological, head and neck cancers. The mechanism of the anticancer action of CDDP is not fully understood, although binding to DNA leads to the formation of inter-and intrastrand cross-links, resulting in impaired DNA synthesis and replication, further inducing cell death.…”