Clinical Significance of Detecting Lymphatic and Blood Vessel Invasion in Stage II Colon Cancer Using Markers D2-40 and CD34 in Combination

et al. 2020

BMC Cancer

Background: Lymphovascular invasion (LVI) has never been revealed by preoperative scans. It is necessary to use digital mammography in predicting LVI in patients with breast cancer preoperatively. Methods: Overall 122 cases of invasive ductal carcinoma diagnosed between May 2017 and September 2018 were enrolled and assigned into the LVI positive group (n = 42) and the LVI negative group (n = 80). Independent t-test and χ2 test were performed. Results: Difference in Ki-67 between the two groups was statistically significant (P = 0.012). Differences in interstitial edema (P = 0.013) and skin thickening (P = 0.000) were statistically significant between the two groups. Multiple factor analysis showed that there were three independent risk factors for LVI: interstitial edema (odds ratio [OR] = 12.610; 95% confidence interval [CI]: 1.061-149.922; P = 0.045), blurring of subcutaneous fat (OR = 0.081; 95% CI: 0.012-0.645; P = 0.017) and skin thickening (OR = 9.041; 95% CI: 2.553-32.022; P = 0.001). Conclusions: Interstitial edema, blurring of subcutaneous fat, and skin thickening are independent risk factors for LVI. The specificity of LVI prediction is as high as 98.8% when the three are used together.

Section: Discussionmentioning

confidence: 99%

Value of digital mammography in predicting lymphovascular invasion of breast cancer

et al. 2020

BMC Cancer

“…The specificity of LVI prediction was as high as 98.8% when these three imaging patterns were applied together. Discussion lymphovascular invasion (intralymphovascular tumor emboli) is closely related to the adverse outcome of many malignant tumors [16][17][18]. As a risk factor for recurrent breast cancer following modified radical mastectomy, lymphovascular tumor emboli, especially lymphatic tumor emboli, has been included in the St Gallen consensus for breast cancer [19].…”

Section: The Image Patterns Of Digital Mammographymentioning

confidence: 99%

Value of digital mammography in predicting lymphovascular invasion of breast cancer

et al. 2019

Preprint

“…4. Discussion lymphovascular invasion (intralymphovascular tumor emboli) is closely related to the adverse outcome of many malignant tumors [16][17][18]. As a risk factor for recurrent breast cancer following modi ed radical mastectomy, lymphovascular tumor emboli, especially lymphatic tumor emboli, has been included in the St Gallen consensus for breast cancer [19].…”

Section: The Image Patternsof Digital Mammographymentioning

confidence: 99%

Value of digital mammography in predicting lymphovascular invasion of breast cancer

et al. 2019

Preprint

Background: To use digital mammography, a more popular imaging tool, for predicting lymphovascular invasion(LVI) in breast cancer patients preoperatively.Methods: 122 cases of invasive ductal carcinoma diagnosed between May 2017 and September 2018 were collected, which were divided into positive group (n=42) and negative group (n=80) according to the presence or absence of LVI.Results: The differences of these variables(childbearing history, miscarriage history, other breast diseases history, nipple discharge, breast cancer marker CA153, age, ER, PR, HER-2, E-CAD, P53, Ki-67) between LVI positive group and the LVI negative group were not statistically significant, except that of Ki-67 (P=0.012). For the image features of digital mammography, the differences of interstitial edema (P=0.013) and skin thickening (P=0.000) between LVI positive group and negative groups were statistically significant. The differences of other imaging patterns, that is, fibroglandular tissue density, size , solitary/multiple, mass shape, mass margin , subcutaneous fat, axillary adenopathy and so on, between the two groups were not statistically significant. Multiple factor analysis shows that, there are three independent risk factors for predicting LVI occurrence: interstitial edema (OR = 12.610, 95% confidence interval CI: 1.061, 149.922, P=0.045), subcutaneous fat (OR=0.081, 95% confidence interval CI: 0.012, 0.645, P =0.017) and skin thickening (OR=9.041, 95% confidence interval CI: 2.553, 32.022, P=0.001).Conclusion: Interstitial edema, blurring of subcutaneous fat layer, and skin thickening were independent risk factors for predicting LVI occurrence. When applying these three imaging patterns together, the specificity of LVI prediction was as high as 98.8%.