Value of digital mammography in predicting lymphovascular invasion of breast cancer

Abstract

Background: Lymphovascular invasion (LVI) has never been revealed by preoperative scans. It is necessary to use digital mammography in predicting LVI in patients with breast cancer preoperatively. Methods: Overall 122 cases of invasive ductal carcinoma diagnosed between May 2017 and September 2018 were enrolled and assigned into the LVI positive group (n = 42) and the LVI negative group (n = 80). Independent t-test and χ2 test were performed. Results: Difference in Ki-67 between the two groups was statistically significant (P = 0.012). Differences in interstitial edema (P = 0.013) and skin thickening (P = 0.000) were statistically significant between the two groups. Multiple factor analysis showed that there were three independent risk factors for LVI: interstitial edema (odds ratio [OR] = 12.610; 95% confidence interval [CI]: 1.061-149.922; P = 0.045), blurring of subcutaneous fat (OR = 0.081; 95% CI: 0.012-0.645; P = 0.017) and skin thickening (OR = 9.041; 95% CI: 2.553-32.022; P = 0.001). Conclusions: Interstitial edema, blurring of subcutaneous fat, and skin thickening are independent risk factors for LVI. The specificity of LVI prediction is as high as 98.8% when the three are used together.

Predicting lymphovascular invasion in clinically node-negative breast cancer detected by abbreviated magnetic resonance imaging: Transfer learning vs. radiomics

“…Previous studies have investigated preoperative LVI prediction with various imaging modalities. Digital mammography was reported to be insufficient in predicting LVI ( 27 ). Ultrasound, especially the elastic heterogeneity value achieved high sensitivity but mediocre specificity ( 28 ).…”

Readout‐Segmented Echo‐Planar Diffusion‐Weighted MR Imaging Improves the Differentiation of Breast Cancer Receptor Statuses Compared With Conventional Diffusion‐Weighted Imaging

“…ER‐ or PR‐positive tumors were defined as tumors with at least 1% of cells that were positively stained according to immunohistochemistry 2,20 . HER‐2‐positive tumors were defined as tumors with scores of 3+ or tumors with scores of 2+ and positive fluorescence in situ hybridization results of HER‐2 gene amplification 21 . A Ki‐67 index ≥20% indicated high expression 2,20 …”

“…2,20 HER-2-positive tumors were defined as tumors with scores of 3+ or tumors with scores of 2+ and positive fluorescence in situ hybridization results of HER-2 gene amplification. 21 A Ki-67 index ≥20% indicated high expression. 2,20…”

Focus on the Predictive Value of Subclassification of Extratumoral Structural Abnormalities for Malignant Nonspiculate and Noncalcified Masses on Digital Mammography

“…Parenchymal deformation may appear around the mass or the whole breast. The possibility of extensive edema by lymphatic tumor emboli (Liu et al, 2020) should be considered when the mass is accompanied by diffuse distortion of parenchyma. Furthermore, parenchymal atrophy sign was also an independent predictor with high PPV (76.8%), which may be related to the dominant growth of carcinoma.…”