Clinical significance of dynamic detection for serum levels of MCP-1, TNF-α and IL-8 in patients with acute pancreatitis

Yang, Yuanzheng; Xiang, Ying; Chen, Mian; Xian, Lina; Deng, Xiaoyan

doi:10.1016/j.apjtm.2016.09.001

Cited by 17 publications

(13 citation statements)

References 4 publications

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“…TNF-α is a key initiator of pancreatic inflammation (25), and it stimulates acinar cells to increase the release of IL-6 (26,27). The present study demonstrated that the concentrations of serum TNF-α and IL-8 in the MAP group were all lower than those in the SAP group, which was consistent with the results of Yang et al (5) and suggests that TNF-α and IL-8 are strongly associated with the severity of AP. IL-6, which has an important role in the pathogenesis of the disease, may be used as an early predictive marker for AP severity, and its expression level is positively correlated with AP severity (28,29).…”

Section: Discussionsupporting

confidence: 91%

“…Tumour necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-8 and IL-10 are important inflammatory cytokines markers in the inflammatory development of AP. In a previous study, the changes in monocyte chemoattractant protein (MCP)-1, TNF-α and IL-8 in the serum of the MAP group were different from those of the MSAP and SAP groups, suggesting that the levels of MCP-1, TNF-α and IL-8 are associated with the severity of AP and may serve as diagnostic indicators (5).…”

Section: Introductionmentioning

confidence: 94%

“…Certain studies have reported that levels of cytokines (e.g., TNF-α, IL-6 and IL-8) and miRNAs (e.g., hsa-miR-551b-5p, hsa-miR-126-5p and hsa-miR-146a) may be used to distinguish between different levels of AP severity. Severe forms of AP were associated with the levels of IL-6, IL-10 and IL-1 receptor antagonist in serum (5)(6)(7)(8)(9)(10). However, whether miRNA-binding inflammatory factors are able to predict AP severity has remained to be determined.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of acute pancreatitis severity via determination of serum levels of hsa‑miR‑126‑5p and IL‑6

et al. 2020

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Early assessment of acute pancreatitis (AP) severity is key to its treatment. The present study aimed to explore the role of microRNAs (miRNAs/miRs) combined with inflammatory factors in determining AP severity. For this, serum pro-inflammatory cytokines [tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, IL-8 and IL-10)] and miRNAs [ Homo sapiens (hsa)-miR-548d-5p, hsa-miR-126-5p and hsa-miR-130b-5p] were detected in patients with mild AP (MAP), severe AP (SAP) and recurrent AP (RAP). High expression of IL-10, TNF-α, hsa-miR-126-5p, hsa-miR-548d-5p and hsa-miR-130b-5p was able to distinguish SAP from MAP and RAP (P<0.05). Multifactorial binary logistic regression analysis indicated that IL-1/IL-6 combined with hsa-miR-126-5p/hsa-miR-548d-5p had a significant influence on AP and AP severity (P<0.05). Receiver operating characteristic analysis revealed that IL-1 combined with hsa-miR-126-5p [area under the curve (AUC), 0.926; sensitivity, 90.0%; specificity, 86.7%, P<0.001] and IL-6 combined with hsa-miR-126-5p (AUC, 0.952; sensitivity, 93.3%; specificity, 90.0%; P<0.001) were able to better distinguish MAP from SAP than IL-1/IL-6 combined with hsa-miR-548d-5p, lipase, and amylase. IL-1 or IL-6 combined with hsa-miR-548d-5p (AUC, 0.924; sensitivity, 83.3%; specificity, 93.3%; P<0.001) were able to better distinguish SAP from RAP than IL-1/IL-6 combined with hsa-miR-126-5p, lipase, and amylase. IL-1 combined with hsa-miR-126-5p (AUC, 0.926; sensitivity, 90.0%; specificity, 86.7%; P<0.001) and IL-6 combined with hsa-miR-126-5p (AUC, 0.952; sensitivity, 93.3%; specificity, 90.0%; P<0.001) were able to better differentiate between MAP and RAP than IL-1/IL-6 combined with hsa-miR-548d-5p, lipase, and amylase. These results demonstrated that the combined detection of serum IL-6 and hsa-miR-126-5p may be useful for the early prediction of AP classification.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Assessment of acute pancreatitis severity via determination of serum levels of hsa‑miR‑126‑5p and IL‑6

et al. 2020

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“…MCP-1 is a family member of the C-C chemokines, and it has been thought to be an important inflammatory mediator in the process of acute pancreatitis and to promote distant organ failure [ 20 , 24 ]. In clinical settings, serum MCP-1 has been reported to increase in patients with complicated acute pancreatitis, and MCP-1 has been thought to play a pivotal role in the pathological mechanism of complicated pancreatitis [ 24 , 25 ]. The results of the present study suggest that MCP-1 could be a predictive and prognostic molecular marker for remote organ injuries and severe pancreatitis.…”

Section: Discussionmentioning

confidence: 99%

An immune-modulating formula comprising whey peptides and fermented milk improves inflammation-related remote organ injuries in diet-induced acute pancreatitis in mice

Nakamura¹,

Fukatsu

Sasayama³

et al. 2018

Bioscience of Microbiota, Food and Health

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It has been demonstrated that an immune-modulating enteral formula enriched with whey peptides and fermented milk (IMF) had anti-inflammatory effects in some experimental models when it was administered before the induction of inflammation. Here, we investigated the anti-inflammatory effects of the IMF administration after the onset of systemic inflammation and investigated whether the IMF could improve the remote organ injuries in an acute pancreatitis (AP) model. Mice were fasted for 12 hours and then fed a choline-deficient and ethionine-supplemented diet (CDE diet) for 24 hours to induce pancreatitis. In experiment 1, the diet was replaced with a control enteral formula, and mice were sacrificed at 24-hour intervals for 96 hours. In experiment 2, mice were randomized into control and IMF groups and received the control formula or the IMF respectively for 72 hr or 96 hr. In experiment 1, pancreatitis was induced by the CDE diet, and inflammatory mediators were elevated for several days. Remote organ injuries such as splenomegaly, hepatomegaly, and elevation of the hepatic enzymes developed. A significant strong positive correlation was observed between plasma MCP-1 and hepatic enzymes. In experiment 2, the IMF significantly improved splenomegaly, hepatomegaly, and the elevation of hepatic enzymes. Plasma MCP-1 levels were significantly lower in the IMF group than in the control group. Nutrition management with the IMF may be useful for alleviating remote organ injuries after AP.

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“…Pancreatitis can essentially be divided into two types: chronic pancreatitis (CP) and acute pancreatitis (AP) [Preiss et al, 2012]. AP can be classified in accordance with the severity of the illness, namely as mild acute pancreatitis (MAP), moderately severe acute pancreatitis (MSAP), and severe acute pancreatitis (SAP) [Yang et al, 2016]. AP is initiated by an acute injury, characterized by an acute inflammatory response that is typically unregulated and disproportional in relation to the extent of tissue injury [Whitcomb, 2010;LaRusch and Whitcomb, 2011].…”

mentioning

confidence: 99%

The Role of Serum High Mobility Group Box 1 and Interleukin‐6 Levels in Acute Pancreatitis: A Meta‐Analysis

Wang

Cai

et al. 2017

J of Cellular Biochemistry

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The purpose of this meta-analysis was to comprehensively investigate the correlation between high mobility group box 1 (HMGB1) and interleukin-6 (IL-6) in relation to acute pancreatitis. A highly regulated exploration of various electronic databases, supplemented by manual searching methods, was performed in an attempt to identify pertinent articles of a useful nature. Subsequently, high-quality cohort studies that were deemed to comply with the arduous inclusion and exclusion criteria were selected for our meta-analysis. The extensive data analyses reported in our meta-analysis were conducted in connection with the Comprehensive Meta-analysis 2.0 (CMA 2.0). A total of 395 studies (135 Chinese studies and 260 English studies) were initially retrieved. 27 of those studies were selected for our meta-analysis, comprising of 896 cases of mild acute pancreatitis (MAP), 700 cases of severe acute pancreatitis (SAP) as well as 312 healthy controls. Pooled data suggested that serum HMGB1 and IL-6 levels of SAP and MAP patients were higher than in healthy controls. Moreover, serum HMGB1 and IL-6 levels of SAP patients exhibited significantly higher levels than in that of MAP patients. Based on the rigorous investigation of our meta-analysis, it was concluded that serum HMGB1 and IL-6 levels might be used as effective indicators for pancreatic lesions as well as the degree of inflammatory response, owing ultimately to the observations and data analyses, suggesting that serum HMGB1 and IL-6 levels share a close correlation with the severity of pancreatitis. J. Cell. Biochem. 119: 616-624, 2018. © 2017 Wiley Periodicals, Inc.

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Clinical significance of dynamic detection for serum levels of MCP-1, TNF-α and IL-8 in patients with acute pancreatitis

Cited by 17 publications

References 4 publications

Assessment of acute pancreatitis severity via determination of serum levels of hsa‑miR‑126‑5p and IL‑6

Assessment of acute pancreatitis severity via determination of serum levels of hsa‑miR‑126‑5p and IL‑6

An immune-modulating formula comprising whey peptides and fermented milk improves inflammation-related remote organ injuries in diet-induced acute pancreatitis in mice

The Role of Serum High Mobility Group Box 1 and Interleukin‐6 Levels in Acute Pancreatitis: A Meta‐Analysis

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