Clinical significance of elevated osteopontin levels in head and neck cancer patients

Eto, Mayumi; Kodama, Satoru; Nomi, Nozomi; Uemura, Naomi; Suzuki, Masashi

doi:10.1016/j.anl.2006.11.012

Cited by 14 publications

(13 citation statements)

References 16 publications

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“…Secreted OPN could be detected in plasma or serum, and serum OPN has been shown to be a prognostic factor for tumor progression and survival in a number of cancers, including OSCC . OPN has recently been proposed as a surrogate marker of tumor hypoxia for head and neck cancer, a disease in which oxygenation is of prognostic importance .…”

Section: Discussionmentioning

confidence: 99%

Osteopontin expression is an independent factor for poor survival in oral squamous cell carcinoma: a computer‐assisted analysis on TMA sections

Avirović

Matušan-Ilijaš

Damante

et al. 2013

J Oral Pathology Medicine

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Section: Discussionmentioning

confidence: 99%

Osteopontin expression is an independent factor for poor survival in oral squamous cell carcinoma: a computer‐assisted analysis on TMA sections

Avirović

Matušan-Ilijaš

Damante

et al. 2013

J Oral Pathology Medicine

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“…Despite of improved modern therapeutic interventions, the 5-year survival rate for this disease has improved only marginally over the past decade and recurrent disease is observed in 50% of the patients (Le et al, 2003;Eto et al, 2007;Pulte et al, 2010). The median overall survival for patients with recurrent or metastatic SCCHN remains less than 1 year (Price et al, 2012).…”

Section: Serum Vascular Endothelial Growth Factor-a (Vegf-a) As a Biomentioning

confidence: 99%

Serum Vascular Endothelial Growth Factor-A (VEGF-A) as a Biomarker in Squamous Cell Carcinoma of Head and Neck Patients Undergoing Chemoradiotherapy

Srivastava

Gara²,

Rastogi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…OPN expression has been shown to be a prognostic indicator of survival among patients with advanced cancer. Elevated serum levels of OPN coincide with decreased survival rates among patients [3]. We have previously demonstrated that OPN has a role in osteoclast bone resorption [4] and prostate cancer cell migration [5], survival [6], and invasion [7].…”

Section: Introductionmentioning

confidence: 99%

Regulation of Erk1/2 activation by osteopontin in PC3 human prostate cancer cells

2010

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BackgroundOsteopontin (OPN) has been shown to play many roles in the progression of cancer. We have recently demonstrated the activation of Akt by OPN. Integrin-linked kinase and PI3-kinase are integral proteins in OPN/AKT pathway in PC3 cells. To investigate the role of the extracellular receptors in OPN signaling, we have examined the spatio-temporal regulation of CD44 and integrin αvβ3 receptor in OPN-induced Akt activation in PC3 cells.ResultsHere, our studies demonstrate that OPN can activate Akt either through the αVβ3 integrin or the CD44 cell surface receptor. Members of the Mitogen Activated Protein Kinase (MAPK) family have been shown to be up-regulated in a variety of human cancers and have been implicated in the metastatic behavior. Our studies have demonstrated an increase in the phosphorylation of c-Raf at Ser259 and Ser338 in PC3 cells over-expressing OPN. This increase matches up with the Erk1/2 phosphorylation at Thr202/204 and activation. However, the inhibition of Akt activity augments the phosphorylation state of ERK1/2 to two to three fold with a concomitant reduction in the phosphorylation state of c-Raf at Ser259.ConclusionsRegulation c-Raf phosphorylation at Ser259 has a role in the anti-apoptotic pathways mediated by Akt or Raf/MEK/ERK proteins. OPN may have dual effects in the activation of Erk1/2. We propose this based on the observations that while OPN activates c-Raf and Erk1/2; it also acts to inhibit c-Raf and Erk1/2 activation through Akt pathway. Our observations suggest that the activation of c-Raf-ERK cascade may promote cell cycle arrest in prostate cancer cells and OPN signaling has a role in the anti-apoptotic mechanism.

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Clinical significance of elevated osteopontin levels in head and neck cancer patients

Cited by 14 publications

References 16 publications

Osteopontin expression is an independent factor for poor survival in oral squamous cell carcinoma: a computer‐assisted analysis on TMA sections

Osteopontin expression is an independent factor for poor survival in oral squamous cell carcinoma: a computer‐assisted analysis on TMA sections

Serum Vascular Endothelial Growth Factor-A (VEGF-A) as a Biomarker in Squamous Cell Carcinoma of Head and Neck Patients Undergoing Chemoradiotherapy

Regulation of Erk1/2 activation by osteopontin in PC3 human prostate cancer cells

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