Clinical significance of exosomes as potential biomarkers in cancer

Wong, Chi Hin; Chen, Yangchao

doi:10.12998/wjcc.v7.i2.171

Cited by 79 publications

(101 citation statements)

References 95 publications

Supporting

Mentioning

100

Contrasting

Order By: Relevance

“…Cancer cells abundantly produce exosomes, and plasma of patients with cancer is enriched in tumor cell derived-exosomes. As the molecular content (such as miRNAs and proteins) of these exosomes recapitulate contents of the parent cell, they appear as possible non-invasive biomarkers of tumor progression and tumor angiogenesis [149] (Fig. 5a).…”

Section: Perspectivementioning

confidence: 99%

Tumor cells derived-exosomes as angiogenenic agents: possible therapeutic implications

2020

View full text Add to dashboard Cite

Angiogenesis is a multistep process and various molecules are involved in regulating it. Extracellular vesicles are cellderived particles, secreted from several types of cells and are known to mediate cell-to-cell communication. These vesicles contain different bio-molecules including nucleic acids, proteins, and lipids, which are transported between cells and regulate physiological and pathological conditions in the recipient cell. Exosomes, 30-150 nm extracellular vesicles, and their key roles in tumorigenesis via promoting angiogenesis are of great recent interest. In solid tumors, the suitable blood supply is the hallmark of their progression, growth, and metastasis, so it can be supported by angiogenesis. Tumor cells abundantly release exosomes containing different kinds of biomolecules such as angiogenic molecules that contribute to inducing angiogenesis. These exosomes can be trafficked between tumor cells or between tumor cells and endothelial cells. The protein and nucleic acid cargo of tumor derived-exosomes can deliver to endothelial cells mostly by endocytosis, and then induce angiogenesis. Tumor derived-exosomes can be used as biomarker for cancer diagnosis. Targeting exosome-induced angiogenesis may serve as a promising tool for cancer therapy. Taken together, tumor derived-exosomes are the major contributors in tumor angiogenesis and a supposed target for antiangiogenic therapies. However, further scrutiny is essential to investigate the function of exosomes in tumor angiogenesis and clinical relevance of targeting exosomes for suppressing angiogenesis.

show abstract

Section: Perspectivementioning

confidence: 99%

Tumor cells derived-exosomes as angiogenenic agents: possible therapeutic implications

2020

View full text Add to dashboard Cite

show abstract

“…One of the most common alternative approaches under consideration for use of EVs as biomarkers is that of the dosage of the RNA species, particularly of miRs, determined by qRT-PCR followed by protein assessment, using either ELISA or mass spectrometry [ 199 ]. However, a major problem that may arise, particularly in assessing RNAs content in EVs, is that of sensitivity of RNA species to particular transport and storage conditions.…”

Section: Evs Used As Diagnostic Markersmentioning

confidence: 99%

Tiny Actors in the Big Cellular World: Extracellular Vesicles Playing Critical Roles in Cancer

Jurj

Pop-Bica

Slabý

et al. 2020

IJMS

View full text Add to dashboard Cite

Communications among cells can be achieved either via direct interactions or via secretion of soluble factors. The emergence of extracellular vesicles (EVs) as entities that play key roles in cell-to-cell communication offer opportunities in exploring their features for use in therapeutics; i.e., management and treatment of various pathologies, such as those used for cancer. The potential use of EVs as therapeutic agents is attributed not only for their cell membrane-bound components, but also for their cargos, mostly bioactive molecules, wherein the former regulate interactions with a recipient cell while the latter trigger cellular functions/molecular mechanisms of a recipient cell. In this article, we highlight the involvement of EVs in hallmarks of a cancer cell, particularly focusing on those molecular processes that are influenced by EV cargos. Moreover, we explored the roles of RNA species and proteins carried by EVs in eliciting drug resistance phenotypes. Interestingly, engineered EVs have been investigated and proposed as therapeutic agents in various in vivo and in vitro studies, as well as in several clinical trials.

show abstract

“…The significance of exosomes in the cell to cell communication and transportation of unique genetic materials could be considered as biomarkers in the diagnosis and therapy of various diseases. Cancer studies showed that exosomes can be considered as potential biomarkers in diagnosis and prognosis of cancer (Wong and Chen, 2019). Besides, it was also revealed that DNM3, p65, and p53 followed a dysregulated-patterns in the brain and blood exosomes in both original and recurrent stages of glioblastoma multiforme.…”

Section: Introductionmentioning

confidence: 99%

The Function of Astrocyte Mediated Extracellular Vesicles in Central Nervous System Diseases

Gharbi

Zhang

Yang

2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Astrocyte activation plays an important role during disease-induced inflammatory response in the brain. Exosomes in the brain could be released from bone marrow (BM)derived stem cells, neuro stem cells (NSC), mesenchymal stem cells (MSC), etc. We summarized that exosomes release and transport signaling to the target cells, and then produce function. Furthermore, we discussed the pathological interactions between astrocytes and other brain cells, which are related to brain diseases such as stroke, Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) disease, multiple sclerosis (MS), psychiatric, traumatic brain injury (TBI), etc. We provide up-to-date, comprehensive and valuable information on the involvement of exosomes in brain diseases, which is beneficial for basic researchers and clinical physicians.

show abstract

Clinical significance of exosomes as potential biomarkers in cancer

Cited by 79 publications

References 95 publications

Tumor cells derived-exosomes as angiogenenic agents: possible therapeutic implications

Tumor cells derived-exosomes as angiogenenic agents: possible therapeutic implications

Tiny Actors in the Big Cellular World: Extracellular Vesicles Playing Critical Roles in Cancer

The Function of Astrocyte Mediated Extracellular Vesicles in Central Nervous System Diseases

Contact Info

Product

Resources

About