Clinical significance of expression of Klotho and β-Catenin in esophageal squamous cell carcinoma

Tang, Xiaowei; Huang, Shu Hong; Wang, Min; Ji, Guozhong; Fan, Zhining

doi:10.11569/wcjd.v20.i34.3305

Cited by 1 publication

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“…Previous studies have demonstrated that oncogenes, such as p53, c-Myc, matrix metallopepti- dase 9 and human sterile alpha motif domain-containing 9, are abnormally expressed in ESCC tissues (22)(23)(24). Furthermore, increased expression levels of transforming growth factor-β may stimulate the PTEN/PI3K pathway and promote epithelial-mesenchymal transition in the human esophageal epithelium (25).…”

Section: Discussionmentioning

confidence: 99%

Low expression of microRNA-202 is associated with the metastasis of esophageal squamous cell carcinoma

Zhang

Dong

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The present study aimed to determine the expression levels and biological functions of in patients with esophageal squamous cell carcinoma (ESCC). A total of 60 patients with ESCC and 30 healthy individuals were enrolled and reverse transcription-quantitative polymerase chain reaction was performed to measure the expression levels of miR-202. In order to investigate the effects of miR-202 expression levels on the proliferative, migratory and invasive abilities of ESCC cells, methylthiazolyl-tetrazolium bromide proliferation, in vitro scratch and Transwell ® chamber assays were performed. Expression levels of miR-202 were significantly decreased in the peripheral blood of patients with ESCC, which is associated with the degree of cell differentiation and lymph node metastasis (P<0.05). Following miR-202 transfection, cell proliferation was significantly inhibited (P<0.05). Cell migration and invasion was also significantly inhibited by miR-202 transfection (P<0.05). The results of the present study demonstrated that the expression of miR-202 inhibited the proliferation, migration and invasion of ESCC cells. Furthermore, low expression levels of miR-202 were detected in the peripheral blood of patients with ESCC, which is associated with the development, invasion and metastasis of ESCC.

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