Clinical significance of gastroesophageal reflux disease with minimal change: a multicenter prospective observational study

Abstract

Non-erosive reflux disease (NERD) is classified into grade N (no minimal change) and grade M (minimal change) based on the Los Angeles classification. However, few reports have described the clinical characteristics of grade M. This study was performed to clarify the clinical characteristics of grade M. Among 290 consecutive patients with gastroesophageal reflux disease (GERD), 45 patients with grade M, 62 patients with grade N, and 94 patients with grade A were compared with respect to clinical differences. The degree of symptom improvement after 4 weeks of proton pump inhibitor administration was also prospectively compared among the three groups. Grades N and M showed no or little difference in the patients’ backgrounds (including sex and body mass index), GERD/functional dyspepsia symptom scores, life dissatisfaction (diet, sleep, work, and mood), Short Form-8 (mental component summary) scores, and symptom improvement. In contrast, significant differences were present between grades M and A as well as between grades N and A. The overall results of our study suggest that the distinction between grade M and grade N is of little clinical significance from the viewpoint of clinical characteristics.

Comparative Study Between the Efficacies of Vonoprazan Versus Omeprazole in Patients with Gastroesophageal Reflux Disease

“…Endoscopy is used to identify GERD, as well as clinical signs including heartburn and acid regurgitation. The two types of GERD either erosive or non-erosive reflux disease [NERD] [3] .…”

“…It consists of 7 acidreflux related and 5 symptoms of dysmotility [No. 2,3,5,8,11] of GERD the higher scores the more directive to GERD [Table 3] [11] . Patients were examined clinically and the basic laboratory investigations were done [CBC, ESR, S. creatinine, S. Urea, ALT, AST, S. Albumin, S. Bilirubin, PT, PTT, INR] and Upper endoscopy with biopsy to exclude Barrett's esophagus before the start of treatment.…”

Controlled One‐Step Synthesis of MOF‐on‐MOF Cocatalysts for Two‐Channel Electrocatalytic Conversion of CO2 to Formic Acid

“…[29] In recent years, MOFs have shown great potential in the fields of photocatalysis, electrocatalysis, and photoelectrocatalysis. [30][31][32][33][34][35][36] They have the potential to serve as porous platforms for the assembly of extremely high densities of catalytically active sites, [37] while providing mass-transport conduits accessible for the diffusion of ions and catalytic-substrates to the active sites. [29,38] Metal ions supported and protected by organic frameworks can ensure a long-term stability.…”