Clinical Significance of Gender and Body Mass Index in Asian Patients with Colorectal Cancer

Rim, Chai Hong; Kim, Chul Yong; Yang, Dae Sik; Yoon, Won Sup

doi:10.7150/jca.28495

Cited by 8 publications

(8 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, one study showed that underweight BMI showed no significant difference in OS compared to normal BMI in patients with stage III CRC (HR, 1.29; 95% CI, 0.77 to 2.19) [ 5 ], although the exact reason of this discordance was unclear. Some speculate that being underweight reflects a more advanced disease status and this may be translated into worse outcomes [ 8 , 23 ]. In our study, the rate of stage III also tended to be higher in patients with underweight BMI, although this did not reach statistical significance.…”

Section: Discussionmentioning

confidence: 99%

Association of Body Mass Index with Survival in Asian Patients with Colorectal Cancer

Lee

et al. 2022

Cancer Res Treat

View full text Add to dashboard Cite

The clinical significance of body mass index (BMI) on long-term outcomes has not been extensively investigated in Asian patients with colorectal cancer (CRC). This study aims to describe the association between BMI and survival, plus providing BMI cut-off value for predicting prognosis in CRC patients. Materials and MethodsA total of 1,182 patients who had undergone surgery for stage I-III CRC from June 2004 to February 2014 were included. BMI was categorized into four groups based on the recommendation for Asian ethnicity. The optimal BMI cut-off value was determined to maximize overall survival (OS) difference. ResultsIn multivariable analysis, underweight BMI was significantly associated with poor OS (hazard ratio [HR] = 2.38, 95% confidence interval [CI] = 1.55-3.71, p<0.001) and obese BMI was associated with better OS (HR = 0.72, 95% CI = 0.53-0.97, p=0.036) compared with the normal BMI. Overweight and obese BMI were associated with better recurrence-free survival (RFS) (HR = 0.64, 95% CI = 0.42-0.99, p=0.046; HR = 0.58, 95% CI = 0.38-0.89, p=0.014, respectively) compared with the normal BMI group. BMI cut-off value was 20.44 kg/m 2 .Adding the BMI cut-off value to cancer staging could increase discriminatory performance in terms of integrated area under the curve and Harrell's concordance index. ConclusionCompared to normal BMI, underweight BMI was associated with poor survival whereas obese BMI was associated with better survival. BMI cut-off value of 20.44 kg/m 2 is a useful discriminator in Asian patients with CRC.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of Body Mass Index with Survival in Asian Patients with Colorectal Cancer

Lee

et al. 2022

Cancer Res Treat

View full text Add to dashboard Cite

show abstract

“…A study performed on the Korean population reported around 12% lower risk of distal cancer in the female than male patients. 52 The combinational study involving systematic review and meta-analysis from different geographic regions around the world revealed that men were at greater risk for advanced colorectal neoplasia. 53 The etiology for the difference remained uncertain.…”

Section: Discussionmentioning

confidence: 99%

“…Subgroup analyses showed a significantly higher risk of colorectal polyps in male NAFLD cohort, whereas no risk was observed in the female cohort. A study performed on the Korean population reported around 12% lower risk of distal cancer in the female than male patients 52 . The combinational study involving systematic review and meta‐analysis from different geographic regions around the world revealed that men were at greater risk for advanced colorectal neoplasia 53 .…”

Section: Discussionmentioning

confidence: 99%

High risk of colorectal polyps in men with non‐alcoholic fatty liver disease: A systematic review and meta‐analysis

Chen

Wang

Jing

et al. 2020

J of Gastro and Hepatol

View full text Add to dashboard Cite

Background and Aim: This meta-analysis aims to explore the risk of colorectal polyps among non-alcoholic fatty liver disease (NAFLD) patients. Methods: We searched PubMed, EMBASE, and Cochrane library databases using predefined search term to identify eligible studies (published up to 7 November 2019). Data from selected studies were extracted by using a standardized information collection form, and meta-analyses were performed using random-effects model. The statistical heterogeneity among studies (I 2), subgroup analyses, meta-regression analyses, and the possibility of publication bias were assessed. Results: Twenty observational (12 cross-sectional, two case-control, and six cohort) studies met the eligibility criteria, involving 142 387 asymptomatic adults. In cross-sectional/ case-control studies, NAFLD was found to be associated with an increased risk of colorectal polyps (odds ratio [OR] = 1.34; 95% confidence interval [CI] = 1.23-1.47) (including unclassified colorectal polyps, hyperplastic polyps, adenomas, and cancers) with statistically significant heterogeneity (I 2 = 67.8%; P < 0.001). NAFLD was also associated with a higher risk of incident colorectal polyps (hazard ratio = 1.60; 95% CI = 1.36-1.87) with low heterogeneity (I 2 = 21.8%; P = 0.263) in longitudinal studies. The severity of NAFLD was associated with a higher risk of colorectal adenomas (OR = 1.57; 95% CI = 1.30-1.88), but not colorectal cancer (OR = 1.37; 95% CI = 0.92-2.03). The subgroup analysis according to gender showed that NAFLD was significantly associated with a higher risk of colorectal polyps in the male population without significant heterogeneity (OR = 1.47; 95% CI = 1.29-1.67, I 2 = 0%), but not in the female population (OR = 0.88; 95% CI = 0.60-1.29, I 2 = 34.2%). Conclusions: NAFLD was associated with an increased risk of colorectal polyps. There was a significant difference of the relationship between genders, which suggested more precise screening colonoscopy recommendation in NAFLD patients according to gender.

show abstract

“…We inferred the results may be related to obesity and lipid metabolism. Obesity demonstrates a major public health issue because of its derived risk factors which are strongly associated with many diseases including CRC [25]. Studies have shown that decreased HDL is an important determinant of lipid peroxidation and it is of lower level in obese people than in others [26].…”

Section: Discussionmentioning

confidence: 99%

Improved diagnostic value by combining plasma PON1 level with tumor biomarkers in Colorectal Cancer patients

et al. 2020

View full text Add to dashboard Cite

The incidence of colorectal cancer (CRC) ranks third among all cancers in China and improvements in screening for CRC have an important impact on prevention and control of the disease. Paraoxonase 1 (PON1) is a calcium ion-dependent hydrolase that is widely distributed in tissue. Its diagnostic value in colorectal cancer has been reported, but the diagnostic value of combining PON1 with carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), carbohydrate antigen 12-5 (CA12-5) in colorectal cancer has not been evaluated. Experiments were carried out in a total of 284 CRC patients and 90 healthy controls. The primary cohort was randomly divided into training and validation sets. The levels of PON1 in plasma of CRC patients were significantly lower than that in the healthy controls (P < 0.001). It showed excellent diagnostic value with the AUC reaching 0.750 for the training set and 0.742 for the validation set. Furthermore, combining PON1 with CEA, CA12-5, CA19-9 could better classify CRC patients (AUC rising from 0.821, 0.716, 0.712 to 0.875, 0.817 and 0.814, respectively, in the training set, from 0.818, 0.581, 0.593 to 0.854, 0.770, and 0.772 in the validation set). In conclusion, PON1 can serve as a diagnostic biomarker for CRC and raise the sensitivity and specificity when incorporated with traditional tumor biomarkers.

show abstract

Clinical Significance of Gender and Body Mass Index in Asian Patients with Colorectal Cancer

Cited by 8 publications

References 50 publications

Association of Body Mass Index with Survival in Asian Patients with Colorectal Cancer

Association of Body Mass Index with Survival in Asian Patients with Colorectal Cancer

High risk of colorectal polyps in men with non‐alcoholic fatty liver disease: A systematic review and meta‐analysis

Improved diagnostic value by combining plasma PON1 level with tumor biomarkers in Colorectal Cancer patients

Contact Info

Product

Resources

About