Improved diagnostic value by combining plasma PON1 level with tumor biomarkers in Colorectal Cancer patients

Zhang, Jingdan; Yang, Xiangling; Wei, Lili; Tan, Huiliu; Chen, Junxiong; Li, Weiqian; Chan, Ka-Wo; Su, Yixi; Zhao, Lu; Hu, Suhua; Zhong, Shuoxian; Xiao, Yanhong; Liu, Huanliang

doi:10.7150/jca.45204

Cited by 8 publications

(5 citation statements)

References 30 publications

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“…This also verifies why CEA is the only tumor marker recommended as routine screening for colorectal cancer in the National Comprehensive Cancer Network guidelines [ 19 ]. Our results also showed that CEA had the best screening efficiency for colorectal cancer among all single indicators, with an AUCROC of 0.847 and specificity up to 91.00%, which is similar to the results reported by Zhang et al [ 20 ] and Huang et al [ 21 ]. However, our results showed that CEA sensitivity was only 70.59%.…”

Section: Discussionsupporting

confidence: 91%

Application Value of Combined Detection of NLR, PNI, D-Dimer, CD3+ T Lymphocytes, and CEA in Colorectal Cancer Screening

Ding

Chen

et al. 2022

Disease Markers

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Objective. To investigate the application value of combined detection of neutrophil-lymphocyte ratio (NLR), prognostic nutrition index (PNI), D-dimer (D-D), CD3+ T lymphocytes (CD3+ T), and carcinoembryonic antigen (CEA) in colorectal cancer screening. Methods. The study cohort comprised 187 colorectal cancer patients and 100 mixed hemorrhoids patients as controls from January 2019 to August 2021 at the Fifth Affiliated Hospital of Sun Yat-sen University. Comparing the levels of NLR, PNI, D-D, CD3+ T, and CEA between the two groups of subjects, drawing receiver operating characteristic (ROC) curve evaluates the efficacy of single and combined detection for colorectal cancer screening. Results. Compared with the control group, the levels of NLR, D-D, and CEA in the colorectal cancer group were significantly increased, while the levels of PNI and CD3+ T were significantly decreased ( P < 0.05 ). ROC curve analysis showed that the combined detection of NLR, PNI, D-D, CD3+ T, and CEA for colorectal cancer screening had an AUCROC of 0.943, a sensitivity of 84.49%, a specificity of 91.00%, and a Youden index of 0.75, and its screening efficacy was significantly superior to that of a single detection ( P < 0.001 ). Conclusion. The combined detection of NLR, PNI, D-D, CD3+ T, and CEA has a high clinical application value for colorectal cancer and can provide a reference for early screening and auxiliary diagnosis of colorectal cancer.

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Section: Discussionsupporting

confidence: 91%

Application Value of Combined Detection of NLR, PNI, D-Dimer, CD3+ T Lymphocytes, and CEA in Colorectal Cancer Screening

Ding

Chen

et al. 2022

Disease Markers

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“…26 In the current study, the AUC for serum CEA was 0.814, which was similar to that reported previously. 27,28 Only MMP-7 and TIMP-1 levels showed better diagnostic values, and thus deserve close attention, whereas MMP-9, MMP-11, TIMP-2, and CA19-9 appeared less promising. Both the specificity and sensitivity were improved using a combined detection model including MMP-7, TIMP-1, and CEA, with acceptable results.…”

Section: Discussionmentioning

confidence: 98%

Diagnostic values of MMP-7, MMP-9, MMP-11, TIMP-1, TIMP-2, CEA, and CA19-9 in patients with colorectal cancer

Huang

Lan

et al. 2021

J Int Med Res

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Objective Colorectal cancer (CRC) is one of the most common and lethal malignancies. The identification of precise and noninvasive biomarkers is urgently needed to aid the early diagnosis and clinical management of CRC. Methods A total of 112 patients with CRC and 115 healthy control subjects were included in this study. Serum levels of matrix metalloproteinase (MMP)-7, MMP-9, MMP-11, tissue inhibitor of metalloproteinase (TIMP)-1, and TIMP-2 were analyzed by enzyme-linked immunosorbent assay, and carcinoembryonic antigen (CEA) and carbohydrate antigen (CA)19-9 levels were measured using an automatic immunoassay analyzer. Results MMP-7, MMP-9, MMP-11, TIMP-1, TIMP-2, CEA, and CA19-9 levels were all significantly higher in CRC patients compared with healthy controls. MMP-7, TIMP-1, and CEA levels were also closely related to clinicopathologic features in patients with CRC. The combination of serum CEA, MMP-7, and TIMP-1 significantly improved the diagnostic value compared with any single marker (area under the curve 0.858–0.890). Furthermore, a combined detection model including MMP-7, TIMP-1, and CEA improved both the specificity and sensitivity for detecting CRC. Conclusions The results showed that combined detection of CEA, MMP-7, and TIMP-1 in serum could provide a specific and sensitive biomarker for the diagnosis of CRC.

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“…CRC is a common digestive tract malignancy with a high incidence and mortality rate, and early diagnosis is crucial for the health examination population [ 21 , 22 ]. Investigations of novel biomarkers, especially blood-based biomarkers for early diagnosis of CRC, are highly warranted because liquid biopsy is convenient and minimally invasive [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Potential roles of serum ATPase and AMPase in predicting diagnosis of colorectal cancer patients

Shi

Tian

et al. 2022

Bioengineered

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Colorectal cancer (CRC) is a common gastrointestinal cancer with high incidence and mortality rates. CRC may be associated with regulation of circulating nucleotides. This study aimed to evaluate the serum levels of nucleotide-metabolizing enzymes (ATPase and AMPase) in patients with CRC and to explore the clinical diagnostic value of these enzymes. The gene set variation analysis (GSVA) score of the ATP-adenosine signature was calculated using tumor samples from The Cancer Genome Atlas (TCGA). ATP-adenosine signaling plays a central role in CRC progression. A total of 135 subjects, including 87 patients with CRC and 48 healthy controls, were included. The serum levels of ATPase and AMPase in the CRC group were significantly higher than those in the control group ( P < 0.05). Furthermore, ATP and AMP hydrolysis levels significantly increased in the advanced CRC group ( P < 0.05). ATP and AMP hydrolysis was decreased by the ENTPDase inhibitors (POM-1 and ARL67156) and CD73 inhibitor (APCP). The sensitivities of ATPase and AMPase were 95.4% and 75.9%, respectively, which were higher than those of CEA (67.8%) and CA19-9 (72.4%). The specificities of ATPase and AMPase were 69.9% and 73.9%, respectively, which were higher than that of CA19-9 (47.8%). The combination of CEA, ATPase, and AMPase demonstrated high sensitivity (92.0%) and specificity (87.0%). Collectively, ATPase and AMPase activities are upregulated in CRC with considerable diagnostic significance. The combination of CEA, ATPase, and AMPase may provide a novel approach for CRC screening.

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Improved diagnostic value by combining plasma PON1 level with tumor biomarkers in Colorectal Cancer patients

Cited by 8 publications

References 30 publications

Application Value of Combined Detection of NLR, PNI, D-Dimer, CD3+ T Lymphocytes, and CEA in Colorectal Cancer Screening

Application Value of Combined Detection of NLR, PNI, D-Dimer, CD3+ T Lymphocytes, and CEA in Colorectal Cancer Screening

Diagnostic values of MMP-7, MMP-9, MMP-11, TIMP-1, TIMP-2, CEA, and CA19-9 in patients with colorectal cancer

Potential roles of serum ATPase and AMPase in predicting diagnosis of colorectal cancer patients

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