Clinical significance of high expression of stanniocalcin-2 in hepatocellular carcinoma

Wang, Yuan; Wu, Jian; Xu, Jiangyan; Lin, Shenyou shen

doi:10.1042/bsr20182057

Cited by 25 publications

(21 citation statements)

References 29 publications

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“…Both STC2 mRNA and protein expression were related to tumor size, stage, metastasis, and differentiation in hepatocellular carcinoma. The hepatocellular carcinoma patients with higher expression of STC2 also had shorter median survival time (68). Furthermore, ectopic expression of STC2 promoted hepatocellular carcinoma cell proliferation and colony formation.…”

Section: Tumor Biologymentioning

confidence: 89%

“…Role of STC2 in human cancers has been studied from two different perspectives namely expression of STC2 in specific cancer models and cell lines, and STC2's function in cell growth, differentiation and apoptosis. Several reports suggest elevated expression of STC2 in human hepatocellular carcinoma, neuroblastoma, breast cancer, colorectal cancer, renal cell carcinoma, esophageal squamous cell cancer, and prostate cancer (41,(64)(65)(66)(67)(68)(69). Additionally, expression of STC2 was correlated with tumor invasion, metastasis and size in gastric cancers and hepatocellular carcinoma (70).…”

Section: Tumor Biologymentioning

confidence: 98%

“…In gastric cancer patients, STC2 expression in circulating tumor cells as well as serum STC2 levels were positively correlated with pathological diagnosis and prognosis (71,72). Study by Wang et al indicated elevated levels of STC2 in hepatocellular carcinoma tissues and were related to tumor size and multiplicity of hepatocellular carcinoma (68). Both STC2 mRNA and protein expression were related to tumor size, stage, metastasis, and differentiation in hepatocellular carcinoma.…”

Section: Tumor Biologymentioning

confidence: 99%

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New Insights Into Physiological and Pathophysiological Functions of Stanniocalcin 2

Joshi

2020

Front. Endocrinol.

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Stanniocalcin, a glycosylated peptide hormone, first discovered in a bony fish has originally been shown to play critical role in calcium and phosphate homeostasis. Two paralogs of stanniocalcin (STC1 and STC2) identified in mammals are widely expressed in variety of tissues. This review provides historical perspective on the discovery of fish and mammalian stanniocalcin, describes molecular regulation of STC2 gene, catalogs distribution as well as expression of STC2 in tissues, and provides key structural information known till date regarding mammalian STC2. Additionally, this mini review summarizes pivotal functions of STC2 in calcium and phosphate regulation, cytoprotection, cell development, and angiogenesis. Finally, STC2's role as a novel marker for human cancers has also been outlined. Reviewing these studies will provide an opportunity to understand STC2's structure, biological functions as well as key molecular pathways involving STC2, which will help us design innovative therapeutic interventions using this novel hormone.

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Section: Tumor Biologymentioning

confidence: 89%

Section: Tumor Biologymentioning

confidence: 98%

Section: Tumor Biologymentioning

confidence: 99%

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New Insights Into Physiological and Pathophysiological Functions of Stanniocalcin 2

Joshi

2020

Front. Endocrinol.

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“…Umezaki et al concluded that LOX induced epithelial-mesenchymal transition and could be used to predict intrahepatic metastasis in HCC ( 35 ). Wang et al ( 36 ) reported that high expression of STC2 may be associated with HCC occurrence, development, and prognosis. Although no evidence has been found to support the three other genes, they may be novel predictors in HCC.…”

Section: Discussionmentioning

confidence: 99%

Hypoxic Characteristic in the Immunosuppressive Microenvironment of Hepatocellular Carcinoma

Liu

Rong

et al. 2021

Front. Immunol.

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Background: Generally, hepatocellular carcinoma (HCC) exists in an immunosuppressive microenvironment that promotes tumor evasion. Hypoxia can impact intercellular crosstalk in the tumor microenvironment. This study aimed to explore and elucidate the underlying relationship between hypoxia and immunotherapy in patients with HCC.Methods: HCC genomic and clinicopathological datasets were obtained from The Cancer Genome Atlas (TCGA-LIHC), Gene Expression Omnibus databases (GSE14520) and International Cancer Genome Consortium (ICGC-LIRI). The TCGA-LIHC cases were divided into clusters based on single sample gene set enrichment analysis and hierarchical clustering. After identifying patients with immunosuppressive microenvironment with different hypoxic conditions, correlations between immunological characteristics and hypoxia clusters were investigated. Subsequently, a hypoxia-associated score was established by differential expression, univariable Cox regression, and lasso regression analyses. The score was verified by survival and receiver operating characteristic curve analyses. The GSE14520 cohort was used to validate the findings of immune cell infiltration and immune checkpoints expression, while the ICGC-LIRI cohort was employed to verify the hypoxia-associated score.Results: We identified hypoxic patients with immunosuppressive HCC. This cluster exhibited higher immune cell infiltration and immune checkpoint expression in the TCGA cohort, while similar significant differences were observed in the GEO cohort. The hypoxia-associated score was composed of five genes (ephrin A3, dihydropyrimidinase like 4, solute carrier family 2 member 5, stanniocalcin 2, and lysyl oxidase). In both two cohorts, survival analysis revealed significant differences between the high-risk and low-risk groups. In addition, compared to other clinical parameters, the established score had the highest predictive performance at both 3 and 5 years in two cohorts.Conclusion: This study provides further evidence of the link between hypoxic signals in patients and immunosuppression in HCC. Defining hypoxia-associated HCC subtypes may help reveal potential regulatory mechanisms between hypoxia and the immunosuppressive microenvironment, and our hypoxia-associated score could exhibit potential implications for future predictive models.

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“…STC2 is involved in the paracrine and autocrine regulation by expressing in tissues and participating in phosphateregulating physiology, metabolism, regeneration, stress response and development [21,22] . Moreover, it was discovered that expression of STC2 changed overtly in solid cancers such as colorectal cancer, nasopharyngeal carcinoma, endometrial carcinoma, gastric carcinoma, hepatocellular carcinoma, SCCHN, which indicated that STC2 took effect in cancer development and progression, including promoting cancer cells invasion and metastasis, suppressing the cells apoptosis and so on [23][24][25][26][27][28] . Our finding of confirmatory test also demonstrated that STC2 may take part in regulatory network of…”

Section: Evaluation Of Cancer-promoting Mechanism Of Lncrna Mafg-as1mentioning

confidence: 99%

Long non-coding RNA MAFG-AS1 promotes proliferation and metastasis of breast cancer by modulating STC2 pathway

Di¹,

Lu²,

Chen³

et al. 2020

Preprint

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Objective Breast cancer is the most common cancer in Chinese women. A number of studies proposed that long non-coding RNA plays an essential role in the regulation of invasion and metastasis of various forms of malignancy, including lung cancer, gastric cancer and bladder cancer. In this study, a long non-coding RNA MAFG-AS1 was explored in detail to understand the significance in the etiology of breast cancer.Methods Quantitative reverse transcription PCR (qRT-PCR) was used to examine the expression level of LncRNA MAFG-AS1 in tissues and cell lines. The association of LncRNA MAFG-AS1 expression and the postoperative prognosis was analyzed by the Kaplan-Meier method and log-rank test. Cell proliferation was evaluated in vitro and in vivo . Transwell assays were performed to examine the cell migration. Cell cycle and apoptosis was evaluated by flowcytometry analysis. The downstream target gene STC2 of LncRNA MAFG-AS1 was screened using the microarray analysis, which was validated by qRT-PCR, functional analysis, and rescue experiment.Results Expression of LncRNA MAFG-AS1 in the breast cancer tissues was significantly higher than the precancerous lesions. Elevated expression level of LncRNA MAFG-AS1 was correlated to the larger GTV (gross tumor volume), negative expression of ER, PR, Her2, lymph node metastasis, and poor prognosis. The potency of breast cancer proliferation, invasion and metastasis was inhibited in the absence of LncRNA MAFG-AS1.Tumorigenic capacity of breast cancer cells was inhibited in the absence of LncRNA MAFG-AS1. The downstream target gene regulated by LncRNA MAFG-AS1 was screened out by gene chip technology, GO analysis and QRT-PCR ultimately. Disrupted STC2 suppressed the cell proliferation and metastasis when the level of LncRNA MAFG-AS1 elevated.Conclusion The LncRNA MAFG-AS1 triggers tumorigenesis in the breast cancer and regulates breast cancer proliferation and metastasis by modulating the downstream target gene STC2. Results from our study indicates that LncRNA MAFG-AS1 can be used.

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Clinical significance of high expression of stanniocalcin-2 in hepatocellular carcinoma

Cited by 25 publications

References 29 publications

New Insights Into Physiological and Pathophysiological Functions of Stanniocalcin 2

New Insights Into Physiological and Pathophysiological Functions of Stanniocalcin 2

Hypoxic Characteristic in the Immunosuppressive Microenvironment of Hepatocellular Carcinoma

Long non-coding RNA MAFG-AS1 promotes proliferation and metastasis of breast cancer by modulating STC2 pathway

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