Clinical significance of human papilloma virus infection in the cervical lesions

Li, Shuang; Meng, Yong; Hu, Ting; Shen, Jian; Ma, Ding

doi:10.1007/s11684-010-0094-6

Cited by 4 publications

(2 citation statements)

References 42 publications

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“…We analyzed the prevalence of total infections and multiple infections in all age groups, which was slightly different from other studies in China. The distribution of total HPV infections and multiple infections in squamous intraepithelial lesions in each age group displayed a double peak phenomenon at 25 and 55 years old and our data presented a similar trendiness as previously reported 18 . In the glandular epithelial lesions, the prevalence of total infections showed unimodal distribution and was the highest in the 35 to 45 aged group.…”

Section: Discussionsupporting

confidence: 90%

The prevalence, genotype distribution of human papillomavirus and cervical cytology in Wenzhou, China: a retrospective research of 7391 cases

Lin

Zhuang

et al. 2020

Diagnostic Cytopathology

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BackgroundHuman papillomavirus (HPV) infection is the main pathogen of precancerous transformation and finally progress to cervical cancer. It associated with cervical squamous and glandular lesions. However, the genotype distribution of HPV and the relationship between HPV infection and cervical disease are still remind unclear.Material and methodsA total of 7391 abnormal cervical cytology cases with detailed histological reports and HPV genotypes were collected. The prevalence of HPV infection in squamous epithelial lesions and glandular epithelial lesions were statistically analyzed.ResultAround 6958 cytological squamous epithelial lesions and 433 glandular epithelial lesions were enrolled. 79.72% of cytological squamous epithelial lesions and 26.56% of glandular epithelial lesions were HPV infected. The HPV infection rates in squamous cell carcinoma, cervical adenocarcinoma and endometrial adenocarcinoma were 66.67%, 54.17% and 19.72%, respectively. HVP16, 18 and 58 are the most common types in squamous and glandular epithelial lesions. Among the squamous epithelial lesions, women less than 25 years old had the highest HPV infection rate, and majority of multiple infections was found in women >55 years old. The total infection rate of HPV in glandular epithelial lesions was the highest in the 35 to 45 group. Multiple infections peaked in women around 55 years old.ConclusionThe prevalence of HPV infection is divergent in different types of cervical cancer. The HPV infections in cervical squamous epithelial lesions tended to be younger. HPV detection is one of the necessary tests for cervical disease screening and should be individualized in an age manner.

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Section: Discussionsupporting

confidence: 90%

The prevalence, genotype distribution of human papillomavirus and cervical cytology in Wenzhou, China: a retrospective research of 7391 cases

Lin

Zhuang

et al. 2020

Diagnostic Cytopathology

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“…However, li et al 18 documented that two-thirds of young women with high viral loads of HPV had no abnormal cytology, showing that cytological abnormalities are not a constant following to HPV infection. The median time to clear HPV infection varies with clearance definition (e.g., how many tests and over what time period were performed) and the estimates range from 8 to 18 months 19 .…”

Section: Discussionmentioning

confidence: 99%

História Natural de Lesões Precursoras do Câncer do Colo do Útero: Estudo Exploratório de uma Coorte de Mulheres do Rio de Janeiro - RJ, Brasil

Silva¹,

Koifman²,

Koifman³

et al. 2012

Rev. Bras. Cancerol.

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Introdução: Neoplasia de Itraepitelial Cervical (NIC ) quando não tratada progride para câncer, persiste como NIC ou regride para um tecido normal. Objetivo: Determinar o padrão de evolução natural das lesões precursoras do câncer cervical e avaliar o papel de cofatores sobre o risco de desenvolvimento dessa neoplasia numa coorte de mulheres do Rio de Janeiro, Brasil. Método: Foi feito um estudo exploratório em 227 mulheres com NIC referidas a partir do Centro de Patologia Cervical, de 1998 2000. A evolução das NIC foi verificada em pacientes que foram deixadas sem tratamento por apresentarem limitações clínicas, que foram seguidas por dois anos com exames citológicos. Resultados citológicos foram classificados como: Lesão de Baixo Grau (LBG), Lesão de Alto Grau (LA G). Probabilidade e risco de regressão, persistência e progressão das lesões pré-cancerosas foram determinados usando test (L-R:95%) de Kaplan Meier e regressão de Cox proporcional. Resultados: A probabilidade de regressão da lesão foi: 46% (LBG), 72,8% (LAG). As LAG apresentaram maior probabilidadde de progressão para câncer (7,1%) e persistência (43,1%) do que LBG. Mulheres <30 anos eram mais propensas a regredir (79,9%) do que as mulheres mais velhas. Mulheres≥50 eram mais prováveis de apresentar lesão persistente (43,3%) do que as mulheres mais jovens (31,8%). Conclusão: Mulheres < 30 anos no diagnóstico de LBG eram mais propensas a regredir do que as mulheres mais velhas. Mulheres com≥50 anos com HSIL eram mais sujeitas a ter lesões persistentes e progredirem, em comparação as mais jovens.

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Molecular Identification of Human Papilloma Virus in Tissue Samples from Patients with Cervical Cancer by Multiplex PCR Method

Masoumalinejad

Zinatizadeh

2018

hrjbaq

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Introduction: Contamination with high-risk human papillomavirus (HPV) is one of the most important risk factors for developing cervix cancer. Since there is no possibility of detecting the virus and its subtypes by using serological methods and cell culture, the molecular methods such as multiplex PCR have particular importance in accurate, early and definite diagnosis of this virus. So, in this research, our goal is to use a proprietary multiplex PCR assay based on HPV-16 and HPV-18 of human papillomavirus for molecular recognition of HPV and to evaluate its prevalence in cervix cancer patients. Materials and Methods: In this experimental study, after collecting samples from malignant cervical lesions of the 60 patients, the viral DNA was extracted and multiplex PCR was done by specific primers of human papillomavirus in all samples. After the analysis of multiplex PCR products by 1% agarose gel electrophoresis, specificity of the test was also evaluated. Results: Among 60 samples, 19 cases were confirmed to be positive for HPV contamination and 41 cases were negative. Therefore the prevalence of HPV contamination was reported 30% in this population. Conclusions: This study showed that Multiplex PCR by specific primers for HPV-16 and HPV-18 of human papilloma virus is a proper and accurate method for detection of this virus and the results also confirm the previous reports of correlation between HPV and cervical carcinoma in Iranian population.

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Clinical significance of human papilloma virus infection in the cervical lesions

Cited by 4 publications

References 42 publications

The prevalence, genotype distribution of human papillomavirus and cervical cytology in Wenzhou, China: a retrospective research of 7391 cases

The prevalence, genotype distribution of human papillomavirus and cervical cytology in Wenzhou, China: a retrospective research of 7391 cases

História Natural de Lesões Precursoras do Câncer do Colo do Útero: Estudo Exploratório de uma Coorte de Mulheres do Rio de Janeiro - RJ, Brasil

Molecular Identification of Human Papilloma Virus in Tissue Samples from Patients with Cervical Cancer by Multiplex PCR Method

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