Clinical significance of ragA, ragB, and PG0982 genes in Porphyromonas gingivalis isolates from periodontitis patients

Bunte, Kübra; Kühn, Christina; Walther, Carolin; Peters, Ulrike; Aarabi, Ghazal; Smeets, Ralf; Beikler, Thomas

doi:10.1111/eos.12776

Cited by 9 publications

(10 citation statements)

References 69 publications

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“…8,9 It is well-documented that periodontal disease is a complex disease with multiple potential contributing factors. These include genetic 10 and epigenetic influences, 11 medication use 12 and/or environmental factors, 13 which together promote periodontal disease initiation and progression. Low socioeconomic status, poor oral hygiene, and oral health related behaviors, psychological stress, and/or depression, increased age, ethnicity, diet/obesity, and systemic health comorbidities are risk factors that contribute to the prevalence of periodontal diseases.…”

Section: Introductionmentioning

confidence: 99%

Prevalence, extent, and severity of periodontitis among Australian older adults: Comparison of two generations

Harford

Luzzi

et al. 2022

Journal of Periodontology

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Background Chronic periodontitis is highly prevalent among older adults. The study aimed to compare periodontal disease among Australian older adults in two generations. We hypothesized that the prevalence and severity of periodontitis would decrease from the previous generation to the recent generation. Methods Data were obtained from the South Australian Dental Longitudinal Study (SADLS) in 1991 to 1992 (SADLS I) and 2013 to 2014 (SADLS II); population‐based longitudinal surveys of Australian older adults aged ≥60 years. American Academy of Periodontology, the US Centers for Disease Control and Prevention (AAP/CDC), and the 2018 European Federation of Periodontology (EFP/AAP) classification case definitions were used to define and calculate prevalence of chronic periodontitis. Multivariable log‐Poisson regression models were used to identify risk indicators for severe periodontitis after adjusting for other covariates. Results There were a total of 801 and 355 participants that underwent a periodontal exam in SADLS I and II, respectively. The prevalence of severe periodontitis was higher in the recent generation (88% and 56%) than the previous generation (75% and 46.7%) under the CDC/AAP and EFP/AAP case definitions, respectively. The mean number of missing teeth was lower in the recent generation (6) than the previous generation (13). The prevalence ratio of severe periodontitis was around two times higher in the younger age group, men, those not born in Australia, and current smokers across both generations. Conclusions Our findings indicated that the recent generation of older adults has higher prevalence and severity of chronic periodontitis than the previous generation. Our findings indicated that aging, being male, born overseas, low household income, no dental insurance, and being a current smoker are significant risk factors associated with severe periodontitis among older Australians.

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Section: Introductionmentioning

confidence: 99%

Prevalence, extent, and severity of periodontitis among Australian older adults: Comparison of two generations

Harford

Luzzi

et al. 2022

Journal of Periodontology

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“…Further univariate and multivariate Cox hazard regression analyses indicated that stage, M and RRAGB could all serve as independent prognostic factors for COAD. As reported by previous researches, Bunte et al found that RRAGB was more prevalent in periodontitis patients than healthy controls and might be associated with periodontitis clinical manifestations [30]. Shi et al successfully constructed a signature based on CHMP4C, FOXO1, RRAGB, and effectively predicted the cervical cancer patients' prognosis [13].…”

Section: Discussionmentioning

confidence: 89%

Elevated Ras related GTP binding B (RRAGB) expression predicts poor overall survival and constructs a prognostic nomogram for colon adenocarcinoma

Xiao¹,

Liu

et al. 2021

Bioengineered

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Currently, no articles have explored the roles of RRAGB gene in the occurrence and development of cancer. By means of The Cancer Genome Atlas (TCGA) data mining, we found that this gene might be a novel prognostic predictor for colon adenocarcinoma (COAD). Hence, this article was carried out to explore its roles in COAD and associations with immunity. RRAGB single-gene expression matrix and corresponding clinical information were extracted from TCGA database. Univariate/multivariate cox regression analyses and gene set enrichment analysis (GSEA) were utilized to identify independent prognostic factors and RRAGB related pathways, respectively. Relationships between RRAGB and immunity were also analyzed. Boxplot and K-M survival analysis indicated that RRAGB was not only differently expressed in COAD (P < 0.05), but also significantly associated with overall survival (OS; P < 0.05). Univariate and multivariate Cox hazard regression analyses indicated that RRAGB could serve as an independent prognostic factor for COAD (both P < 0.05). GSEA identified five signaling pathways significantly enriched in the high-RRAGB expression phenotype. Moreover, a RRAGB-based nomogram was successfully constructed and displayed a satisfactory performance. In addition, RRAGB expression was found to be significantly associated with microsatellite instability (MSI), tumor mutational burden (TMB) and immunity. Our results revealed that RRAGB could be a prognostic biomarker for COAD in terms of OS and markedly related to MSI, TMB, and immunity. We also constructed an RRAGB-based nomogram with a satisfactory performance. Further researches should be carried out to validate our findings.

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“…This may be due to the possible effect of IWT on periodontal status, which would be caused by the suppression of chronic inflammation [ 16 , 34 , 35 ]. On the other hand, one of the most important pathogens of periodontal disease, Porphyromonas gingivalis , invades blood vessels from the endothelial cells of the periodontal pocket [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Interval Walking Training on Oral Health Status in Middle-Aged and Older Adults: A Case-Control Study

Yoshimoto

Hirabayashi

Furihata

et al. 2022

IJERPH

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The purpose of this study was to determine the effect of walking training “Interval Walking Training (IWT)” on oral health status. Participants were divided into two groups: an exercise intervention group and a non-intervention group (control). The intervention group consisted of 59 subjects (20 males, 39 females) aged 50 years or older who participated in the IWT program in Matsumoto from 2019 to April 2022. The control group consisted of 33 subjects (14 males and 19 females) aged 50 years or older who have visited Niigata University Medical and Dental Hospital and agreed to participate in the study. The intervention group underwent walking training (interval walking training) for at least 5–6 months. The walking training consisted of five sets of fast walking above 70% peak aerobic capacity for walking (VO2peak) for 3 min, followed by 3 min of slow walking at ~40% VO2 peak per day for more than four days/week. The oral health status was evaluated for the number of teeth, occlusal force, salivary occult blood, masticatory performance, and tongue pressure. A total of 57 participants were analyzed in the intervention group (18 males and 39 females, age: 66.7 ± 0.8 (mean ± S.E.) years) and 33 participants in the control group (14 males and 19 females, age: 74.5 ± 1.1 (mean ± S.E.) years). There were no significant differences in gender, salivary occult blood, tongue pressure, masticatory performance, or occlusal force between the two groups at the start of the intervention (p = 0.36, p = 0.48, p = 0.42, p = 0.58, and p = 0.08, respectively by unpaired t-test or χ2 test). On the other hand, there were significant differences in age and BMI, with a trend toward lower age and higher BMI in the intervention group (p < 0.001 and p < 0.001, respectively, by unpaired t-test). In terms of rate of change, the intervention group showed a significant increase in occlusal force (F = 4.5, p = 0.04, ANCOVA) and a significant decrease in BMI (F = 7.3, p = 0.009, ANCOVA). No significant differences were observed in the other measured items. It was found that walking training in both middle-aged and older people does not only affect the physical aspect of weight loss but may help maintain and improve the occlusal force.

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Clinical significance of ragA, ragB, and PG0982 genes in Porphyromonas gingivalis isolates from periodontitis patients

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 9 publications

References 69 publications

Prevalence, extent, and severity of periodontitis among Australian older adults: Comparison of two generations

Prevalence, extent, and severity of periodontitis among Australian older adults: Comparison of two generations

Elevated Ras related GTP binding B (RRAGB) expression predicts poor overall survival and constructs a prognostic nomogram for colon adenocarcinoma

Effects of Interval Walking Training on Oral Health Status in Middle-Aged and Older Adults: A Case-Control Study

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