Clinical Significance of Joint Detection of Serum VEGF, SIL-2R and HGF in Patients with Primary Hepatocellular Carcinoma before and after Percutaneous Microwave Coagulation Therapy

Chen, Jidong; Xiong, Yan-Qun; Dong, Ke; Luo, Jun; Yue, Linxian; Chen, Qin

doi:10.7314/apjcp.2014.15.11.4545

Cited by 6 publications

(1 citation statement)

References 28 publications

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“…Vascular endothelial growth factor (VEGF) is a potent and specific angiogenic factor, was well known to be a key requirement for tumor growth. They activate endothelial cells to proliferate and migrate, subsequently resulting in new tube formation and blood flow (Chen et al, 2014). However, the result gained in this study indicates that B.tomentosa reduced the production of TNFα, iNOS, IL-1β, IL-6, GM-CSF, and VEGF levels clearly express the regulatory effect of this intermediates and tumor inhibition of B. tomentosa.…”

Section: Discussionmentioning

confidence: 54%

Anti-tumor and Chemoprotective Effect of Bauhinia tomentosa by Regulating Growth Factors and Inflammatory Mediators

Kannan

Sakthivel²,

Guruvayoorappan³

2016

Asian Pacific Journal of Cancer Prevention

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of cancer and autoimmune disorders (Haque et al., 2003). CTX has been reported to disturb fundamental mechanisms concerned with cell growth differentiation and function (Alenzi et al., 2010), this chemotherapeutic has also been reported to induce several toxic side effects like nausea, fatigue, hair loss, and to cause reduction in host levels of immune cells (Kiuchi et al., 2009). Due to the toxic side effects of CTX, the need for new drugs effective

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Section: Discussionmentioning

confidence: 54%

Anti-tumor and Chemoprotective Effect of Bauhinia tomentosa by Regulating Growth Factors and Inflammatory Mediators

Kannan

Sakthivel²,

Guruvayoorappan³

2016

Asian Pacific Journal of Cancer Prevention

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Hepatocellular carcinoma: Exploring the impact of ethnicity on molecular biology

Lamarca

Mendiola²,

Barriuso

2016

Critical Reviews in Oncology/Hematology

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Hepatocellular carcinoma (HCC) is the sixth most common cancer in the world and the third leading cause of cancer-related death. The high rate of diagnosis in non-curable stages and the lack of novel active treatments make it necessary to review all the possible sources of misleading results in this scenario. The incidence of HCC shows clear geographical variation with higher annual incidence in Asia and Africa than in Western countries; we aimed to review the literature to find if there are different trends in the main activated molecular pathways. Hyperactivation of RAS/RAF/MEK/ERK and PI3K/AKT/mTOR signalling and epithelial to mesenchymal transition (EMT) process are more prevalent in the Western population; however, fibroblast growth factor (FGF), transforming growth factor β (TGFβ) and Notch pathways seems to be more relevant in Asian population. Whether these variations just reflect the distinct distribution of known causes of HCC or proper ethnical differences remain to be elucidated. Nevertheless, these clearly different patterns are relevant to regional or worldwide clinical trial design. If this information is neglected by sponsors and researchers the rate of failure in HCC trials will not improve.

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Biomarkers in hepatocellular carcinoma: an overview

Juárez-Hernández

Motola-Kuba

Chávez-Tapia

et al. 2017

Expert Review of Gastroenterology & Hepatology

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Current methods for HCC diagnosis have not an optimal diagnostic accuracy. The detection of more than one biomarker seems to improve their individual performance and provide an accurate HCC diagnosis approach. Individual gene expression seems to influence whether or not the treatment is successful, since several molecules have interfere with cancer associated pathways and have been related to poor prognosis which condition the lack of effective treatment options. Areas covered: Novel biomarkers have been proposed as a useful tool in each patient prognosis. This article aims to review the recent evidence based on HCC biomarkers which seems to have a regulative role according to tumor cell development leading to a specific biological response. Epigenetic regulation, miRNAs, and genome sequencing analysis propose molecular expression signatures as novel biomarkers which allowed achieve the major goal for the use of biomarkers in clinical practice. Moreover, a deeper analysis for determine the diagnostic accuracy of biomarkers has been made. Expert commentary: To improve of methodological designs and sample sizes are needed in order to support the role of biomarkers in HCC. Furthermore, is necessary to consider HCC etiologies and all clinic disease context to carried out clinical phase studies to thrust biomarkers application.

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Clinical Significance of Joint Detection of Serum VEGF, SIL-2R and HGF in Patients with Primary Hepatocellular Carcinoma before and after Percutaneous Microwave Coagulation Therapy

Cited by 6 publications

References 28 publications

Anti-tumor and Chemoprotective Effect of Bauhinia tomentosa by Regulating Growth Factors and Inflammatory Mediators

Anti-tumor and Chemoprotective Effect of Bauhinia tomentosa by Regulating Growth Factors and Inflammatory Mediators

Hepatocellular carcinoma: Exploring the impact of ethnicity on molecular biology

Biomarkers in hepatocellular carcinoma: an overview

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