Clinical significance of p53, mdm2, and bcl-2 proteins in renal cell carcinoma

Uchida, Τοyoaki; Gao, Jiang Ping; Chun-xi, Wang; Jiang, Shi Xu; Muramoto, Masatoshi; Satoh, Takefumi; Minei, Sadanori; Shimura, Satoru; Irie, Akira; Kameya, Toru; Baba, Shirō

doi:10.1016/s0090-4295(01)01601-6

Cited by 46 publications

(46 citation statements)

References 20 publications

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“…However, the role of p53 overexpression in RCC is still controversial [13][14][15] . The reported results regarding both the rate of immunoreactive tumours and the impact of p53 overexpression on patient's prognosis are inconsistent [16][17][18] .…”

Section: Discussionmentioning

confidence: 99%

Investigation of tumour supressor protein p53 in renal cell carcinoma patients

Hodorová¹,

Solár²,

Mihálik³

et al. 2014

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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, Silvia Rybarova aBackground. Investigation of p53 immunoreactivity in formalin-fixed paraffin-embedded tissues of normal renal tissue and renal cell carcinoma with respect to histopathologic subtype and nuclear grade of RCC. Methods. 42 tissue sections of RCC and 5 samples of normal renal tissue were stained for p53 expression using immunohistochemical assay. The results were analyzed in relation to nuclear grade and histopathologic subtype. Results. In total, p53 expression was found to be 4 to 5 times higher (30.8%) in other types of RCC than in the clearcell type of RCC (6.9%). Further, there was no statistically significant difference in p53 overexpression among the histopathologic subtypes (P>0.05, P=0.063). No association was found between the expression of p53 and nuclear grade (P>0.05, P=0.17). Interestingly, our study also showed weak cytoplasmic positivity in renal tubular epithelium. Conclusion. Our findings suggest that p53 might play an important role in tumour development or progression and it might be used as a new predictor and therapeutic target for RCC.

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Section: Discussionmentioning

confidence: 99%

Investigation of tumour supressor protein p53 in renal cell carcinoma patients

Hodorová¹,

Solár²,

Mihálik³

et al. 2014

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…AKT can inactivate p53, contributing to centrosome hyperamplification and chromosome instability in cancer [23][24][25]. Luo et al and Carroll et al have provided an in-depth focus on the role of the PI3K/AKT pathway in cell proliferation and survival [26,27].…”

Section: Discussionmentioning

confidence: 99%

Expression of AEG-1 and p53 and their clinicopathological significance in malignant lesions of renal cell carcinomas: a microarray study

Erdem¹,

Oktay²,

Yıldırım³

et al. 2013

pjp

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The aim of this study was to investigate the relationship of AEG-1 and p53 with the prognostic parameters of renal cell carcinoma (RCC). In this study, 50 paraffin blocks were histopathologically diagnosed at the Department of Pathology of the Medical Hospital of Duzce University, between 2005 and 2011. The cases consisted of 24 clear cell (CC) and 26 non-clear cell (NCC) RCC subtypes as follows: 24 (48%) clear cell RCC, 12 (24%) papillary RCC, 4 (8%) multilocular cystic RCC and 10 (20%) chromophobe RCC; none had sarcomatoid changes. By immunohistochemical analysis we investigated AEG-1 and p53 expression in carcinomas of the kidney, and by statistical analysis determined their relationship with clinicopathological parameters. Significant relationships were found between increasing tumor diameter and the increase of p53 (p = 0.028). In addition, p53 was significantly related to renal sinus invasion (p = 0.05) and Fuhrman grade (p = 0.026). There was a significant relationship between increased AEG-1 staining scores and CC and NCC carcinoma subtypes (p = 0.032), tumor capsule invasion (p = 0.01) and lymphovascular invasion (p = 0.015). There was also a significant correlation between tumor size and capsule and lymphovascular invasion (p = 0.02). We concluded that high AEG-1 and p53 expression correlates with the prognostic parameters in RCC patients, and in addition may be associated with tumor progression.

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“…Ki67 and p53 are related to cellular proliferation (11)(12)(13). In RCC, Ki67 is an independent predictor of survival (11,12), and a mutated p53 has been shown to be an independent predictor of survival in some studies (14,15).…”

Section: Introductionmentioning

confidence: 99%

Using Protein Expressions to Predict Survival in Clear Cell Renal Carcinoma

Kim¹,

Seligson²,

Liu³

et al. 2004

Clinical Cancer Research

206

123

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Purpose: An accurate system for predicting survival for patients with solid tumors will allow for better patient selection for both established and novel therapies. We propose a staging system for clear cell variants of renal cell carcinoma (RCC) that includes molecular predictors and standard clinical predictors such as tumor-node-metastasis (TNM) stage, histological grade, and performance status (PS).Experimental Design: A custom tissue array was constructed using clear cell RCC from 318 patients, representing all stages of localized and metastatic RCC, and immunohistochemically stained for molecular markers Ki67, p53, gelsolin, CA9, CA12, PTEN, EpCAM, and vimentin. We present a strategy for evaluating individual candidate markers for prognostic information and integrating informative markers into a multivariate prognostic system.Results: The overall median follow-up and the median follow-up for surviving patients were 28 and 55 months, respectively. A prognostic model based primarily on molecular markers included metastasis status, p53, CA9, gelsolin, and vimentin as predictors and had high discriminatory power: its statistically validated concordance index (Cindex) was found to be 0.75. A prognostic model based on a combination of clinical and molecular predictors included metastasis status, T stage, Eastern Cooperative Oncology Group PS, p53, CA9, and vimentin as predictors and had a C-index of 0.79, which was significantly higher (P < 0.05) than that of prognostic models based on grade alone (C ‫؍‬ 0.65), TNM stage alone (C ‫؍‬ 0.73), or the University of California Los Angeles integrated staging system (C ‫؍‬ 0.76).Conclusions: Protein expressions obtained using widely available technology can complement standard clinical predictors such as TNM stage, histological grade, and PS.

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Clinical significance of p53, mdm2, and bcl-2 proteins in renal cell carcinoma

Cited by 46 publications

References 20 publications

Investigation of tumour supressor protein p53 in renal cell carcinoma patients

Investigation of tumour supressor protein p53 in renal cell carcinoma patients

Expression of AEG-1 and p53 and their clinicopathological significance in malignant lesions of renal cell carcinomas: a microarray study

Using Protein Expressions to Predict Survival in Clear Cell Renal Carcinoma

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