Crimean-Congo Hemorrhagic fever (CCHF) is a potentially fatal viral infection with reported case fatality rates of 5-30%. Humans become infected through tick bites, by contact with a patient with CCHF during the acute phase of infection, or by contact with blood or tissues from viraemic livestock. In this first report in the literature, we present the characteristics of three pregnant women with CCHF infection and the outcome of their babies. Transmission of the CCHF infection could be either intrauterine or perinatal. In endemic regions, CCHF infection should be considered in the differential diagnosis of HELLP syndrome (haemolytic anaemia, elevated liver enzymes, low platelet count), and obstetricians should be familiar with the characteristics of CCHF infection. In the aetiology of necrotising enterocolitis, CCHF should be considered.
Most bladder tumors are derived from the urothelium. Benign mesenchymal tumors are rare. Leiomyomas account for less than 0.43% of all bladder tumors. Genitourinary leiomyomata may arise in any anatomic structure containing smooth muscle. They have been reported to involve single or multiple organs. Since they may also mimic malignant lesions, they should always be considered in the differential diagnosis of any pelvic mass, with a possibility of being asymptomatic and discovered incidentally by radiographic imaging. We, herein, report a case illustrating clinical and pathological features in particular immunohistochemistry, and discuss its etiology and differential diagnosis.
The present study demonstrated that, in the prevention of liver damage induced by acetaminophen intoxication, an early treatment with a single dose of erdosteine was beneficial instead of NAC administration.
Long-term systemic use of corticosteroids causes osteoporosis and increased risk of fracture. However, the effect of short-term use of corticosteroids on bone healing is not well defined. The aim of the present study was to test the influence of short-term systemic corticosteroid therapy on bone healing. Standardized bone defects (2 mm diameter) were formed in the middle of the femur in 40 male rats. Rats were divided into two groups; control group (n = 20) and prednisone-treated group (n = 20). Subcutaneous injection of either sterile normal saline (control) or 0.020 mg kg(-1) dose of prednisone was administered just before surgery and thereafter daily for 3 days. Histopathological cross sections were taken 1, 2, 3 and 4 weeks after surgery. There was no statistically significant difference between the prednisone group and the control group. No inhibitory effects were seen following short-term corticosteroid treatment.
Xanthoma disseminatum is a rare, usually self-healing dermatologic disease of unknown etiology. Involvement of other organs and tissues including bone marrow, bone, and brain may be seen rarely in children. However, to date, hepatic involvement has not been reported. We describe a child with xanthoma disseminatum who had hepatic involvement, and discuss his course and treatment with steroid and azathioprine.
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