Pregnancy and Crimean-Congo haemorrhagic fever

Abstract

Crimean-Congo Hemorrhagic fever (CCHF) is a potentially fatal viral infection with reported case fatality rates of 5-30%. Humans become infected through tick bites, by contact with a patient with CCHF during the acute phase of infection, or by contact with blood or tissues from viraemic livestock. In this first report in the literature, we present the characteristics of three pregnant women with CCHF infection and the outcome of their babies. Transmission of the CCHF infection could be either intrauterine or perinatal. In endemic regions, CCHF infection should be considered in the differential diagnosis of HELLP syndrome (haemolytic anaemia, elevated liver enzymes, low platelet count), and obstetricians should be familiar with the characteristics of CCHF infection. In the aetiology of necrotising enterocolitis, CCHF should be considered.

Crimean-Congo Haemorrhagic Fever: Treatment and Use of Ribavirin

“…KKKA'da annenin yaşamının kurtarılması için fetusun tahliyesi gerekebilir; yenidoğanlarda fatalite oranı yüksektir (45). Ribavirin kullanımı gebelikte kontrindikedir (FDA gebelik kategorisi X); ama annenin yaşamının kurtarılması icin gerekli olabilir.…”

Crimean-Congo hemorrhagic fever and pregnancy: Two cases

“…CCHF should be differentiated from HELLP syndrome (hemolytic anemia, elevated liver enzymes, low platelet count) encountered during the pregnancy. 8,9 Tezeret et al,5 in their study on 31 pediatric patients diagnosed with CCHF, reported that all patients recovered from the disease. In addition, laboratory signs and clinical progressions of children were better than those of adults, and the disease progressed more mildly during childhood; however, some pediatric mortal cases have been reported.…”

“…Horizontal transmission of the disease from mother to the fetus was shown. 7 In the study conducted on pregnant CCHF patients by Ergonul et al 8, three pregnant women were followed up, and the virus was detected in the fetus of one patient by using RT-PCR and ELISA. They also reported that one of three patients died with the fetus, whereas other pregnant patients recovered while losing their fetuses.…”

Crimean-Congo Hemorrhagic Fever

“…In a study of three pregnant women with CCHF in Turkey, both the mother and fetus died in one case, and the babies of the two surviving patients died after birth. The authors emphasized that CCHF can cause miscarriage, neonatal complications, and death in pregnant patients, and concluded that outcomes were related to the gestation period (trimester) and the disease severity [74] . In a case report of a patient infected with CCHF in week 30 of pregnancy, the baby was born at 37 weeks completely healthy with no signs or symptoms related to the disease [75] .…”