Clinical Significance of Perihepatic Lymphadenopathy in Patients with Chronic Hepatitis C Infection

Tavakoli–Tabasi, Shahriar; Ninan, Sheeba

doi:10.1007/s10620-010-1555-0

Cited by 7 publications

(6 citation statements)

References 35 publications

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“…It should be noted that controversy still exists regarding whether PLNE could be associated with hepatocellular damage or liver fibrosis in patients with chronic HCV infection . These results raise a possibility that the clinical significance of PLNE may be distinct regarding the association with hepatitis activity between chronic HBV infection and chronic HCV infection.…”

Section: Discussionmentioning

confidence: 99%

“…Perihepatic lymph node enlargement (PLNE) is frequently observed in patients with chronic liver disease, especially in those with hepatitis C virus (HCV) infection . Although some studies have reported that PLNE was associated with inflammatory activity, stage of liver fibrosis or hepatitis viral load, such associations were inconsistent among other studies, suggesting that the clinical significance of PLNE in HCV infection has not been fully established yet. We have recently reported that PLNE is negatively associated with the response to interferon (IFN)‐based treatment or development of HCC in patients with chronic hepatitis C (CHC) .…”

Section: Introductionmentioning

confidence: 99%

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Potential associations between perihepatic lymph node enlargement and liver fibrosis, hepatocellular injury or hepatocarcinogenesis in chronic hepatitis B virus infection

Sato

Hikita

Hagiwara

et al. 2014

Hepatology Research

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Potential associations between perihepatic lymph node enlargement and liver fibrosis, hepatocellular injury or hepatocarcinogenesis in chronic hepatitis B virus infection

Sato

Hikita

Hagiwara

et al. 2014

Hepatology Research

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“…However, controversy still exists regarding the association with hepatocellular damage or liver fibrosis in patients with chronic HCV infection. [9][10][11][12]14,16,17 Further study with larger samples including meta-analysis or further basic research is needed to clarify this point.…”

Section: Discussionmentioning

confidence: 99%

“…Perihepatic lymph node enlargement (PLNE) is an ultrasound (US) finding frequently observed in patients with chronic liver disease, especially in those with HCV. Although some studies have reported that PLNE was associated with inflammatory activity, stage of liver fibrosis or hepatitis viral load, such associations are inconsistent among other studies, suggesting that the clinical significance of PLNE in HCV infection has not been fully established yet. We have previously reported that PLNE is negatively associated with the response to interferon‐based treatment or development of HCC in patients with chronic hepatitis C (CHC) and also reported higher prevalence of PLNE in patients with chronic hepatitis B .…”

Section: Introductionmentioning

confidence: 97%

Disappearance of perihepatic lymph node enlargement after hepatitis C viral eradication with direct‐acting antivirals

Hikita¹,

Sato

Endo³

et al. 2017

Journal of Viral Hepatitis

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Perihepatic lymph node enlargement (PLNE) which has been shown to be negatively associated with hepatocellular carcinoma (HCC) occurrence is frequently observed in chronic liver disease; however, changes in the state of perihepatic lymph nodes after eradication of hepatitis C virus (HCV) have not been investigated yet. We aimed to evaluate this issue. We enrolled 472 patients with chronic HCV infection who achieved viral eradication with direct-acting antivirals (DAA). We investigated whether the status of perihepatic lymph nodes changed before and after HCV eradication (primary endpoint). We also evaluated the association between PLNE and clinical findings such as liver fibrosis or hepatocellular injury before HCV eradication (secondary endpoint). Perihepatic lymph node enlargement was detected in 164 of 472 (34.7%) patients before DAA treatment. Surprisingly, disappearance of PLNE was observed in 23.8% (39 patients) of all PLNE-positive patients after eradication of HCV. Disappearance of PLNE was not associated with baseline clinical parameters or changing rates of clinical findings before and after DAA treatment. At baseline, presence of PLNE was significantly associated with a lower serum HCV-RNA level (P = .03), a higher serum AST level (P = .004) and a higher ALT level (P < .001) after adjustment for sex and age. In conclusion, PLNEs became undetectable after DAA treatment in 23.8% of PLNE-positive patients. Further study with a longer follow-up period is needed to clarify the clinical importance of this phenomenon especially in relationship with the risk of HCC development.

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“…P ERIHEPATIC LYMPH NODE enlargement (PLNE), usually detected by abdominal ultrasonography, is known as a common finding in patients with chronic liver disease, 1 especially in those with hepatitis C. 2,3 Although PLNE in chronic hepatitis C is reportedly associated with inflammatory activity, stage of liver fibrosis [3][4][5][6][7] or hepatitis C viral load, 8 inconsistent findings have been reported, 2,4,9 suggesting that the clinical significance of PLNE in chronic hepatitis C has not been fully under-stood yet. PLNE in chronic hepatitis C has long been assumed to reflect an immunological response of the host.…”

Section: Introductionmentioning

confidence: 99%

Perihepatic lymph node enlargement observed at a general health examination: A cross‐sectional study

Gotoh

Enooku

Soroida

et al. 2012

Hepatology Research

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The incidence of PLNE in the general population may vary with the prevalence of chronic liver disease, especially HCV infection. When PLNE is observed, liver disorders should be first surveyed including HCV infection even with normal serum alanine aminotransferase levels. PLNE with para-aortic lymph node enlargement may be suggestive of a malignant lesion. The incidence of PLNE of unknown etiology may be approximately 1% in the general population, which may be just followed up without further change.

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Clinical Significance of Perihepatic Lymphadenopathy in Patients with Chronic Hepatitis C Infection

Abstract: Presence of PLNE in patients with chronic HCV infection is strongly associated with subclinical cirrhosis. However, PLNE does not independently predict the progression of liver disease to decompensated cirrhosis and/or death in HCV-infected patients.

Cited by 7 publications

References 35 publications

Potential associations between perihepatic lymph node enlargement and liver fibrosis, hepatocellular injury or hepatocarcinogenesis in chronic hepatitis B virus infection

Potential associations between perihepatic lymph node enlargement and liver fibrosis, hepatocellular injury or hepatocarcinogenesis in chronic hepatitis B virus infection

Disappearance of perihepatic lymph node enlargement after hepatitis C viral eradication with direct‐acting antivirals

Perihepatic lymph node enlargement observed at a general health examination: A cross‐sectional study

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