1969
DOI: 10.1016/0002-9343(69)90036-9
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Clinical significance of serum and urinary muramidase activity in leukemia and other hematologic malignancies

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Cited by 101 publications
(32 citation statements)
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“…Osserman and Lawlor and others have noted hypokalemia and hyperkaluria in a number of patients with mono-and myelomonocytic leukemia (7,14,15,36). Excessive excretion rates of potassium, reduced excretion of titratable acid, and glycosuria were also noted in some patients (15).…”
Section: Proteins and Rendl Function In Monocytic Leukemiasmentioning
confidence: 95%
See 1 more Smart Citation
“…Osserman and Lawlor and others have noted hypokalemia and hyperkaluria in a number of patients with mono-and myelomonocytic leukemia (7,14,15,36). Excessive excretion rates of potassium, reduced excretion of titratable acid, and glycosuria were also noted in some patients (15).…”
Section: Proteins and Rendl Function In Monocytic Leukemiasmentioning
confidence: 95%
“…Osserman has suggested that humans and rats with monocytic leukemia, as well as rats injected with exogenous lysozyme, develop "lysozyme nephropathy" (55). It has been shown that the increased concentration of the enzyme in the kidney may be associated with cytoplasmic droplet degeneration of the proximal tubular cells and distortion of the mitochondria and nuclei (16,36). Similarly, in autopsy material available to us, droplets of homogenous eosinophilic substances have been found in the proximal tubular cells in 4 of 12 cases studied.…”
Section: Proteins and Rendl Function In Monocytic Leukemiasmentioning
confidence: 99%
“…Since very high levels are found in leukaemia it should be possible to deduce the threshold using data from leukaemic patients. In this way there have been various estimates: 45 ,ug/ml (Hayslett et al, 1968), more than 50 ,tg/ml (Perillie, Kaplan, Lefkowitz, Rogaway, and Finch, 1968), and variable butnot less than 42 ,tg/ml (Wiernik and Serpick, 1969). …”
Section: Normal Valuesmentioning
confidence: 99%
“…Wiernik and Serpick (1969) found that patients with acute myeloid leukaemia, who had elevated initial serum muramidase levels, fared worse than those with normal or low levels. Castro, Perillie and Finch (1970) came to the opposite conclusion: they reported that patients with high serum lysozyme levels live longer than those with low levels.…”
mentioning
confidence: 99%