Clinical Significance of Serum Carcinoembryonic Antigen (CEA) Level at Diagnosis of Liver Metastases in Patients with Colorectal Cancer

Nam, Jung-Su; Shin, Jin-Yong; Kim, Kyoung-Ha; Park, Jeong-Ik; Kim, Woon-Won; Choi, Chang-Soo; Choi, Young-Gil; Hong, Kwan-Hee

doi:10.3393/jksc.2008.24.6.439

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…The majority of studies evaluating preoperative CEA levels reveal it to be an independent prognostic factor after surgical resection for colorectal cancer [1][2][3][4][5][6][7][8]10], although some contradictory studies reported that the CEA level is a predictor for survival [12][13][14][15][16]. We concur with this and confirmed a preoperative elevation in serum CEA as an independent prognostic factor for both 5-year overall and disease-free survival in this analysis.…”

Section: Discussionsupporting

confidence: 85%

“…Many studies have demonstrated the prognostic value of the preoperative CEA level after surgical resection of colon and rectal cancer, but whether the preoperative CEA level is an independent prognostic variable in colon cancer has remained controversial [12][13][14][15][16]. Therefore, the aim of this study was to assess the prognostic value of the preoperative serum CEA level in patients with colon cancer.…”

Section: Introductionmentioning

confidence: 98%

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Preoperative carcinoembryonic antigen level as an independent prognostic factor in potentially curative colon cancer

Huh

Kim

et al. 2010

Journal of Surgical Oncology

111

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Objective: We evaluated the prognostic value of the preoperative serum carcinoembryonic antigen (CEA) level in patients with colon cancer. Methods: We reviewed 474 patients who underwent potentially curative resection for nonmetastatic colon cancer. Patients were categorized into two groups according to the preoperative serum CEA level: low CEA (<5 ng/ml) and high CEA ( 5 ng/ml) groups. Results: During the median 45-month follow-up period, the 5-year overall and disease-free survival rates for patients with a low CEA level were 81.7% and 82.4%, respectively, which were significantly higher than the rates for those with a high CEA level (69.9%; P ¼ 0.011 and 70.6%; P ¼ 0.002, respectively). A multivariate analysis revealed that a preoperative serum CEA level was a significant independent prognostic factor for both overall survival (P ¼ 0.021) and disease-free survival (P ¼ 0.026). Both the overall and disease-free survival rates in patients with stage II tumors differed significantly between the low and high CEA groups, whereas the rates did not different between those with stage I and III tumors. Conclusions: Preoperative serum CEA is a reliable predictor of recurrence and survival after curative surgery in patients with colon cancer, particularly in those classified as having stage II disease.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 98%

Preoperative carcinoembryonic antigen level as an independent prognostic factor in potentially curative colon cancer

Huh

Kim

et al. 2010

Journal of Surgical Oncology

111

View full text Add to dashboard Cite

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Prognostic value of increased postoperative carcinoembryonic antigen in patients with early intestinal anastomosis leakage who underwent right hemicolectomy surgery

et al. 2022

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Introduction: Anastomotic leak after colorectal surgery is a serious complication that causes significant postoperative morbidity and mortality. Aim: This study aimed to investigate the predictive value of increased postoperative carcinoembryonic antigen (CEA) in early intestinal anastomosis leakage in patients who underwent right hemicolectomy surgery. Material and methods: In this prospective study, 535 patients who underwent right colon cancer surgery with stapled anastomosis were enrolled. A subset of 315 patients was included in the study after meeting the inclusion criteria. Preoperatively, their serum CEA levels were measured, and on postoperative days 3 and 6, the levels were measured again. Results: Early AL occurred in 18 patients (5.71%). The mean ± SD age of patients was 65.06 ± 11.69 years. Increased CEA level was associated with increased odds of intestinal AL among the patients after three and six days of surgery (OR after three days = 1.3; 95%CI = 1.1–1.5, OR after six days = 1.7 95%CI = 1.14–2.5). The mean CEA level significantly increased among patients with anastomose leakage (P-value < 0.001). Conclusion: The results showed that increasing CEA levels can be used as one of the non-invasive markers in detecting early AL in patients with right colon cancer surgery.

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Clinical Significance of Serum Carcinoembryonic Antigen (CEA) Level at Diagnosis of Liver Metastases in Patients with Colorectal Cancer

Cited by 2 publications

References 33 publications

Preoperative carcinoembryonic antigen level as an independent prognostic factor in potentially curative colon cancer

Preoperative carcinoembryonic antigen level as an independent prognostic factor in potentially curative colon cancer

Prognostic value of increased postoperative carcinoembryonic antigen in patients with early intestinal anastomosis leakage who underwent right hemicolectomy surgery

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