Clinical significance of serum interleukin‐8 and soluble tumor necrosis factor‐like weak inducer of apoptosis levels in patients with diabetic nephropathy

Liu, Shuyan; Chen, Jie; Li, Yongfeng

doi:10.1111/jdi.12828

Cited by 29 publications

(26 citation statements)

References 28 publications

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“…Many prein ammatory cells, growth regulators, and adhesion factors interact with each other and cross-link, resulting in expansion of the corresponding cascade of in ammation. (13) In recent years, the rapid development of proteomics technology has provided us with new methods and ideas for identifying early diagnostic markers of DN. Proteomics techniques have been used to identify disease-speci c biomarkers and other related proteins in urine.…”

Section: Discussionmentioning

confidence: 99%

Urinary orosomucoid and retinol binding protein levels as early diagnostic markers for diabetic nephropathy

Zhou¹,

Liu²,

Lin³

et al. 2020

Preprint

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Background:Diagnosing diabetic nephropathy is important to prevent long-term kidney damage and determine the prognosis of patients with diabetes. Since some kidney injury biomarkers increase in the early stages of diabetic nephropathy, this study investigated the clinical significance of combined detection of urine orosomucoid and retinol-binding protein for early diagnosis of diabetic nephropathy.Methods:We included 72 patients with type 2 diabetes and 34 healthy persons between August 2016 and July 2018 at our hospital. Using the Mogensen grading criteria, participants were classified as having diabetes or diabetic nephropathy, and healthy persons constituted the control group. Urine orosomucoid and retinol-binding protein levels were measured and correlated with other variables.Results:Increase in renal damage raised urinary orosomucoid levels gradually (P<0.05). Urinary retinol-binding protein and microalbumin levels were significantly higher in the diabetes group than in control and nephropathy groups. Orosomucoid and retinol-binding protein might be independent risk factors for diabetes and diabetic nephropathy. Urinary orosomucoid significantly correlated with retinol-binding protein and microalbumin levels (r = 0.489 and 0.513, respectively) in the diabetic nephropathy group. The receiver operating characteristic curve yielded a sensitivity, specificity, and correction index of 0.941, 0.842, and 0.783, respectively, while analysis for retinol-binding protein yielded a sensitivity, specificity, and correction index of 0.942, 1.000, and 0.941, respectively.Conclusion:The increase in urine orosomucoid and retinol-binding protein levels can be detected in the early stages of type 2 diabetic nephropathy. Therefore, both markers are important for diabetic nephropathy detection and early treatment.

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Section: Discussionmentioning

confidence: 99%

Urinary orosomucoid and retinol binding protein levels as early diagnostic markers for diabetic nephropathy

Zhou¹,

Liu²,

Lin³

et al. 2020

Preprint

Self Cite

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“…Genetic polymorphism of IL-8 (IL8-rs4073) showed a strong association in Asian people with DN [195]. Other studies showed elevated circulating IL-8 levels in T2DM patients [193]. A bioinformatic analysis in endothelial precursor cells isolated from patients with T2DM showed that IL-8 and CXCL1 genes were the most expressed molecules in diabetic samples [196].…”

Section: Other Cytokines/proinflammatory Proteins In Dnmentioning

confidence: 99%

“…Among several proinflammatory proteins involved in the development and progression of DN is also the cytokine IL-8, which mainly attracts neutrophils and induces oxidative stress, favoring vascular permeability and endothelial damage in the diabetic kidney [193,194]. Genetic polymorphism of IL-8 (IL8-rs4073) showed a strong association in Asian people with DN [195].…”

Section: Other Cytokines/proinflammatory Proteins In Dnmentioning

confidence: 99%

Pathogenic Pathways and Therapeutic Approaches Targeting Inflammation in Diabetic Nephropathy

Rayego‐Mateos

Morgado‐Pascual

Opazo-Ríos

et al. 2020

IJMS

187

127

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Diabetic nephropathy (DN) is associated with an increased morbidity and mortality, resulting in elevated cost for public health systems. DN is the main cause of chronic kidney disease (CKD) and its incidence increases the number of patients that develop the end-stage renal disease (ESRD). There are growing epidemiological and preclinical evidence about the close relationship between inflammatory response and the occurrence and progression of DN. Several anti-inflammatory strategies targeting specific inflammatory mediators (cell adhesion molecules, chemokines and cytokines) and intracellular signaling pathways have shown beneficial effects in experimental models of DN, decreasing proteinuria and renal lesions. A number of inflammatory molecules have been shown useful to identify diabetic patients at high risk of developing renal complications. In this review, we focus on the key role of inflammation in the genesis and progression of DN, with a special interest in effector molecules and activated intracellular pathways leading to renal damage, as well as a comprehensive update of new therapeutic strategies targeting inflammation to prevent and/or retard renal injury.

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“…Recent ndings suggest that immune-mediated in ammatory processes play a crucial role in DN. Many prein ammatory cells, growth regulators, and adhesion factors interact with each other and cross-link, resulting in an expansion of the corresponding cascade of in ammation [10]. In recent years, the rapid development of proteomics technology has provided us with new methods and ideas for identifying early diagnostic markers of DN.…”

Section: Discussionmentioning

confidence: 99%

Urinary orosomucoid and retinol binding protein levels as early diagnostic markers for diabetic nephropathy

Zhou

Liu

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Abstract Background:Diagnosing diabetic nephropathy is important to prevent long-term kidney damage and determine the prognosis of patients with diabetes. Since some kidney injury biomarkers increase in the early stages of diabetic nephropathy, this study investigated the clinical significance of combined detection of urine orosomucoid and retinol binding protein for early diagnosis of diabetic nephropathy.Methods:We recruited 72 patients with type 2 diabetes and 34 healthy persons from August 2016 to July 2018 at our hospital. Using Mogensen grading criteria, participants were classified as diabetes or diabetic nephropathy, and healthy persons constituted the control group. Urine orosomucoid and retinol binding protein were measured and correlated with other variables.Results:Increase in renal damage raised urinary orosomucoid level gradually (P < 0.05). Urinary retinol binding protein and microalbumin levels were significantly higher in the diabetes group than in control and nephropathy groups. Orosomucoid and retinol binding protein might be independent risk factors for diabetes and diabetic nephropathy. Urinary orosomucoid significantly correlated with retinol binding protein and microalbumin (r = 0.489 and 0.513, respectively) in the diabetic nephropathy group. The receiver operating characteristic curve yielded a sensitivity, specificity, and correction index of 0.941, 0.842, and 0.783, respectively, while analysis for retinol binding protein yielded a sensitivity of 0.942, specificity of 1.000, and a correction index of 0.941.Conclusion:The increase in the levels of urine orosomucoid and retinol binding protein can be detected in the early stages of type 2 diabetic nephropathy. Both these markers are important for diabetic nephropathy detection and early treatment.

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Clinical significance of serum interleukin‐8 and soluble tumor necrosis factor‐like weak inducer of apoptosis levels in patients with diabetic nephropathy

Cited by 29 publications

References 28 publications

Urinary orosomucoid and retinol binding protein levels as early diagnostic markers for diabetic nephropathy

Urinary orosomucoid and retinol binding protein levels as early diagnostic markers for diabetic nephropathy

Pathogenic Pathways and Therapeutic Approaches Targeting Inflammation in Diabetic Nephropathy

Urinary orosomucoid and retinol binding protein levels as early diagnostic markers for diabetic nephropathy

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