Clinical significance of serum vascular endothelial growth factor in colorectal cancer patients: correlation with clinicopathological factors and tumor markers.

Clinical Significance of Microvessel Count in Patients with Metastatic Liver Cancer Originating from Colorectal Carcinoma

“…We originally hypothesized that there was a relationship between MVC, vascularity, and histological differentiation because previous studies showed a correlation between tumor angiogenesis and depth of invasion, lymphatic infiltration and lymph node metastasis in colorectal carcinoma patients with liver metastasis. 19,20 Our results showed, however, that MVC was not associated with any clinicopathological parameters of metastatic liver cancer and the meaning of increased microvessel count, at the biologic level, is still unknown at this stage. Although we also examined the significance of MVC in the intrahepatic cholangiocarcinomas, which have a similar morphology to MLC, no relationship with pathological characteristics or patient prognosis after surgery was found.…”

Minimally invasive colon resection for malignant colonic conditions is associated with a transient early increase in plasma sVEGFR1 and a decrease in sVEGFR2 levels after surgery

“…Preoperative plasma levels of VEGF 165 have been shown to be significantly higher in patients with colorectal, gastric, or renal cell tumors than in patients with benign disease. Furthermore, plasma and tumor levels correlate with stage and/or prognosis for a number of cancers [18][19][20][21][22].…”

Persistent elevation of plasma vascular endothelial growth factor levels during the first month after minimally invasive colorectal resection

“…This is true for colorectal, gastric, and renal cell tumors, among others. In some series, preoperative VEGF levels correlate with cancer stage, prognosis, or both [14,16,17].…”