Clinical significance of soluble Fas plasma levels in patients with sepsis

Mikić, Dragan; Vasilijić, Saša; Cucuz, Milica; Čolić, Miodrag

doi:10.2298/vsp140622066m

Cited by 4 publications

(2 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…23 Previous studies from Mikic et al, revealed that soluble Fas concentrations positively correlated with APACHE II scores (r=0.6046, p<0.001). 12 The weak correlation in our study was attributable to several possibilities, such as no uniformity in our study subjects'length of illness before soluble Fas levels were measured, or by factors of flaws in APACHE II score assessments. Soluble Fas levels in this study were indeed measured on the first-day sepsis was diagnosed by a physician, but durations of illness before the subjects came to the Dr. Soetomo Hospital's emergency room were varied.…”

Section: Resultsmentioning

confidence: 66%

See 1 more Smart Citation

Correlation Between Level of Soluble Fas and Degree of Sepsis Severity Based on Apache Ii Score

Hadisiswoyo

Retnowati

Triyono

2018

Indonesian J. Clin. Pathol. Med. Lab.

View full text Add to dashboard Cite

A widely used scoring system to assess the severity of sepsis is Acute Physiology, Age, and Chronic Health Evaluation (APACHE) II scoring system, however there are some disadvantages in using this. Other parameters are needed to predict severity and outcome of sepsis. Proinflammatory cytokines and Fas receptors are increased in sepsis and their concentration elevations are correlated with disease severity. An increase of soluble Fas level will follow increasing Fas receptors. This study aimed to prove any correlation between the level of soluble Fas and degree of sepsis severity based on APACHE II score. A cross-sectional observational study was conducted in January-June 2015 on 30 septic patients. APACHE II scores were calculated from the patients’physiological data, age, and chronic health problem status. Levels of soluble Fas were measured using the ELISA method (Human FAS/ CD95 (Factor-Related Apoptosis) ELISA Kit, Elabscience Biotechnology). Levels of soluble Fas ranged between 1,049-2,783 pg/mL (1,855.7 ± 477.27 pg/mL). APACHE II scores varied between 4-29 (17.2 ± 5.82). Significant positive correlations between levels of soluble Fas and APACHE II score (r=0.347, p=0.03) were found. A prediction model of soluble Fas levels based on APACHE II score was made. Linear regression analysis produced a prediction model of soluble Fas levels based on APACHE II score, in which soluble Fas level= 1,365.8 + 28.485 x APACHE II score.

show abstract

Section: Resultsmentioning

confidence: 66%

“…Fas receptor (CD95/ APO-1) is the central molecule involved in apoptosis in sepsis. 11,12 Sepsis causes the level of proinflammatory cytokines and Fas receptor (Fas rec) to increase and the level of elevation is correlated with disease severity. Increasing level of soluble Fas will follow increasing level of Fas receptor.…”

Section: Introductionmentioning

confidence: 99%