Clinical Significance of Sperm Antibodies in Infertile Couples

Ansbacher, Rudi; Keung-Yeung, Kwok; Behrman, S.J.

doi:10.1016/s0015-0282(16)39616-9

Cited by 55 publications

(22 citation statements)

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“…Sobbe, Haferkamp and Doepfmer (1966) found spermagglutinins in 6 % of 150 infertile men, a number closely agreeing with Fjallbrant's findings of 6.7 % in 400. Phadke and Padukone (1964) and Ansbacher, Manarang-Pangan and Srivannaboon (1971) claim that there is an increase in this antibody titre in men who have undergone vasectomy, and suggest that this may cause infertility in men even where successful reconstruction of the vasa has been accomplished by surgical reanastomosis.…”

mentioning

confidence: 99%

Autoantibodies to Spermatozoa in Relation to Male Infertility and Vasectomy

Halim

1973

British Journal of Urology

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confidence: 99%

Autoantibodies to Spermatozoa in Relation to Male Infertility and Vasectomy

Halim

1973

British Journal of Urology

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“…There is no doubt that some cases of infertility result from women forming antibodies cytotoxic to spermatozoa. Isojima et al (1968) found such antibodies in the sera of three of twenty-five infertile women, and Ansbacher et al (1971) found agglutinating and cytotoxic antibodies in 11 -4% infertile women, but did not differentiate between the two tests. Cytotoxic antibodies were found in the cervical mucus of three women by Parish et al (1967), and in the mucus of two other women and in the serum of one by Parish & Ward (1968).…”

Section: Discussionmentioning

confidence: 98%

“…However, techniques to detect anti-spermatozoal antibodies differ considerably in most laboratories. In the agglutination test, for example, the antigen has been diluted whole semen (Schwimmer, Ustay & Behrman, 1967a, b;Isojima, Li & Ashitaka, 1968) or a suspension of washed spermatozoa (Kibrick, Belding & Merrill, 1952;Ansbacher, Manarang-Pangan & Srivannaboon, 1971). Spermatozoa were living or dead, and the test read macroscopically or microscopically.…”

Section: Introductionmentioning

confidence: 99%

Allergic infertility: laboratory techniques to detect antispermatozoal antibodies

Jeffery

Parish

1972

Clin Experimental Allergy

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Twenty sera from fertile and infertile women were examined for antibodies to spermatozoa or to semitial plasma, to determine which of the five techniques tested provided reliable evidence of allergic infertility.Ten sera agglutinated seminal plasma coated tanned red cells, six agglutinated spermatozoa, ten gave mixed cell antiglobulin agglutination and fourteen gave immunofiuorescent reactions for IgG or igM antispermatozoal antibodies, and three were cytotoxic to sperm.The results of tests for seminal plasma agglutinins were unrelated to those of any of the other tests, and it is believed that factors other than antibody also clump these antigen-coated cells. There was good agreement in the results obtained by direct sperm agglutination, mixed cell antiglobulin agglutination and strong immunofiuorescent staining of the sperm head. The antiglobulin and immunofiuorescent techniques also detect nonagglutinating ('incomplete' or 'univalenf) antibody.One of the three sera cytotoxic to sperm had no antibody detected by the other tests. The sperm may have been killed by an inflammatory substance or a systemically absorbed contraceptive. This case illustrates the necessity of combining tests for cytoxicity with at least one technique for antispermatozoal antibody in order to detect allergic infertility.

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“…because of cervical mucus "hostility" although this remains ill-understood and difficult to quantify. Rumke (1975) claims that only a Kibrick titre of greater than 1 : 32 is relevant to infertility and this correlates with the findings of Ansbacher, Keung-Yeung and Behrman (1973). Isojima c't u/.…”

Section: Failuresmentioning

confidence: 96%