Clinical significance of the BRAFV600E mutation in multifocal papillary thyroid carcinoma in Korea

Ahn, Hwa Young; Chung, Yun Jae; Kim, Byung Seup; Kang, Kyung Ho; Seok, Ju Won; Kim, Hee Sung; Park, Sung Jun; Cho, Bo Youn

doi:10.1016/j.surg.2013.12.025

Cited by 23 publications

(20 citation statements)

References 25 publications

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“…To date, many studies suggested that Hashimoto's thyroiditis was associated with higher frequency of wild-type BRAF. 12,[23][24][25] In this study, DLI with positive TPOAb was a negative independent factor of BRAF V600E mutation and extrathyroidal extension in PTC but DLI without TPOAb was not. [5][6][7][8] However, there were also many studies that reported the BRAF status was not associated with Hashimoto's thyroiditis, or BRAF V600E mutation was even more frequently observed when Hashimoto's thyroiditis was present.…”

Section: Discussionmentioning

confidence: 46%

Association between diffuse lymphocytic infiltration and papillary thyroid cancer aggressiveness according to the presence of thyroid peroxidase antibody and BRAF^V600E mutation

Lee

Park

et al. 2018

Head & Neck

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Section: Discussionmentioning

confidence: 46%

Association between diffuse lymphocytic infiltration and papillary thyroid cancer aggressiveness according to the presence of thyroid peroxidase antibody and BRAF^V600E mutation

Lee

Park

et al. 2018

Head & Neck

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“…In this study, the BRAF V600E mutation status of multifocal PTCs was only determined by the dominant tumour, rather than each focus in individuals. Although this approach may be controversial, according previous studies, most multifocal thyroid carcinoma share identical BRAF V600E status, ranging from 59.4-85.7% [31][32][33][34][35]. Additionally, the most common condition for the mixed BRAF V600E mutation tumour group is that the dominant tumour is BRAF-positive while other foci are partly or all BRAF-negative.…”

Section: Discussionmentioning

confidence: 99%

The synergic effect of BRAF<sup>V600E</sup> mutation and multifocality on central lymph node metastasis in unilateral papillary thyroid carcinoma

Qu¹,

Hu³

et al. 2018

Endocr J

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Abstract. The purpose of this study is to evaluate the potential synergic effect of BRAF V600E mutation and multifocality on central lymph nodes metastasis (CLNM) in the patients with unilateral papillary thyroid carcinoma (PTC). We enrolled 413 patients with unilateral PTCs who accepted prophylactic unilateral or bilateral central lymph node dissection (LND). Univariate and multivariate analyses were made to determine the association between related factors and CLNM. Then, all patients were divided into 4 groups based on their status of BRAF V600E mutation and multifocality. Relative excess risk of interaction (RERI), attributable proportion (AP) of interaction and synergy index (SI) were applied to evaluate the interactive effect of these two factors on CLNM. Results showed that BRAF V600E mutation and multifocality were independent risk factors for CLNM. A further study revealed that unilateral PTCs accompanying multifocality with BRAF V600E mutation had the highest incidence of CLNM compared with other subgroups. Besides, RERI was 4.323 (95% CI = 1.276-7.369), AP was 0.523 (95% CI = 0.364-0.682) and SI was 2.469 (95% CI = 1.607 to 3.794), indicating a significant additive interaction of BRAF V600E mutation and multifocality on CLNM. The present study has confirmed that BRAF V600E mutation and multifocality are risk factors for CLNM in unilateral PTC. Additionally, unilateral PTC patients accompanying multifocality with BRAF V600E mutation may have an increased risk of CLNM in clinically negative CLNM.

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“…Several researches found most of the patients with multifocal PTC had the BRAF V600E mutation in one or more tumor foci and all BRAF V600E -positive multifocal PTC showed more aggressive features [16, 17]. Moreover, many studies have investigated multifocal PTC clonality through a number of approaches, including X-chromosome inactivation, BRAF mutation, RET rearrangements, loss of heterozygosity, or allelic imbalances of distinct cancer foci [17–19].…”

Section: Discussionmentioning

confidence: 99%

Total thyroidectomy may be more reasonable as initial surgery in unilateral multifocal papillary thyroid microcarcinoma: a single-center experience

et al. 2017

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BackgroundThe extent of surgery in patients with unilateral multifocal papillary thyroid microcarcinoma (UMPTMC) remains to be controversial. Aimed to improve surgical management of UMPTMC, this study was performed to identify the recurrence of UMPTMC and analyze its predictive factors.MethodsThis study was approved by the Ethical Committee of The First Hospital of the Jilin University, and written informed consent was given by participants for their clinical records to be used in this study. We retrospectively analyzed a total of 97 consecutive patients who underwent initial surgery for the treatment of UMPTMC at The First Hospital of Jilin University, between October 2005 and October 2006.ResultsAltogether, 97 patients of UMPTMC have been enrolled in our study, in which 57 cases were performed with hemithyroidectomy (HT) while other 40 cases with total thyroidectomy (TT). The sum diameter of all tumors >1 cm was more frequent in HT group than in TT group (40.35 vs 20%; p = 0.046). Positive central lymph nodes were found more frequently in the TT patients than in the HT patients (80 vs 59.65%; p = 0.046). Tumor recurrence was seen more frequently in the HT cases than in the TT cases (26 vs 5%; p = 0.007). The disease-free survival period was significantly shorter for the HT patients than for the TT patients (p = 0.0059 by the log-rank test). The disease-free survival rates at 5 and 10 years were 91.23 and 73.68%, respectively, in the HT group and 100 and 92.5%, respectively, in the TT group. Univariate analysis by Cox’s proportional hazards method showed male gender, sum diameter of all tumors >1 cm, and central lymph node metastases (CLNM) to be risk factors for recurrence of HT patients. Male gender and sum diameter >1 cm were factors identified for multivariate analysis by Cox’s proportional hazards method which yielded risk ratios of 3.037 [CI 1.026–8.988; p = 0.045] and 5.475 [CI 1.389–21.572; p = 0.015] in the HT group.ConclusionsIn summary, with an increased risk of recurrence, TT may be more reasonable as initial surgery in UMPTMC, especially with male gender and total tumor diameter greater than 1 cm.Electronic supplementary materialThe online version of this article (doi:10.1186/s12957-017-1130-7) contains supplementary material, which is available to authorized users.

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Clinical significance of the BRAFV600E mutation in multifocal papillary thyroid carcinoma in Korea

Cited by 23 publications

References 25 publications

Association between diffuse lymphocytic infiltration and papillary thyroid cancer aggressiveness according to the presence of thyroid peroxidase antibody and BRAF^V600E mutation

Association between diffuse lymphocytic infiltration and papillary thyroid cancer aggressiveness according to the presence of thyroid peroxidase antibody and BRAF^V600E mutation

The synergic effect of BRAF<sup>V600E</sup> mutation and multifocality on central lymph node metastasis in unilateral papillary thyroid carcinoma

Total thyroidectomy may be more reasonable as initial surgery in unilateral multifocal papillary thyroid microcarcinoma: a single-center experience

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Clinical significance of the BRAFV600E mutation in multifocal papillary thyroid carcinoma in Korea

Cited by 23 publications

References 25 publications

Association between diffuse lymphocytic infiltration and papillary thyroid cancer aggressiveness according to the presence of thyroid peroxidase antibody and BRAFV600E mutation

Association between diffuse lymphocytic infiltration and papillary thyroid cancer aggressiveness according to the presence of thyroid peroxidase antibody and BRAFV600E mutation

The synergic effect of BRAF<sup>V600E</sup> mutation and multifocality on central lymph node metastasis in unilateral papillary thyroid carcinoma

Total thyroidectomy may be more reasonable as initial surgery in unilateral multifocal papillary thyroid microcarcinoma: a single-center experience

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Association between diffuse lymphocytic infiltration and papillary thyroid cancer aggressiveness according to the presence of thyroid peroxidase antibody and BRAF^V600E mutation

Association between diffuse lymphocytic infiltration and papillary thyroid cancer aggressiveness according to the presence of thyroid peroxidase antibody and BRAF^V600E mutation