Clinical significance of the serum IL-2R level and Ga-67 scan findings in making a differential diagnosis between sarcoidosis and non-Hodgkin's lymphoma

Kita, Tamotsu; Watanabe, Sadahiro; Yano, Fumihiko; Hayashi, Katsumi; Yamamoto, Masayoshi; Iwasaki, Yoshie; Kosuda, Shigeru

doi:10.1007/s12149-007-0060-9

Cited by 13 publications

(13 citation statements)

References 8 publications

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“…In line with previous works, we found that serum sIL‐2R levels were significantly higher than normal in patients with sarcoidosis (Fig. ).…”

Section: Discussionsupporting

confidence: 92%

“…Soluble interleukin‐2 receptor (sIL‐2R) is a 55‐kDa protein released mainly by activated T lymphocytes; therefore, levels of sIL‐2R have been considered to be a marker of T‐cell activation . In sarcoidosis, increased levels of sIL‐2R in serum and bronchoalveolar lavage fluid (BALF) have been reported, and serum levels of sIL‐2R were correlated with various indices of disease severity, including angiotensin‐converting enzyme (ACE), radiographic stage of disease, gallium‐67 ( 67 Ga) scintigraphy uptake and CD4 + T‐lymphocyte number in BALF…”

Section: Introductionmentioning

confidence: 99%

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Serum soluble interleukin‐2 receptor level is more sensitive than angiotensin‐converting enzyme or lysozyme for diagnosis of sarcoidosis and may be a marker of multiple organ involvement

Nguyen

Kambe

Kishimoto

et al. 2017

The Journal of Dermatology

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Skin lesions in sarcoidosis are often the initial symptoms that enable the dermatologist to be the first to diagnose this granulomatosis. However, diagnosis is sometimes very problematic. In 2015, the diagnostic criteria for sarcoidosis were updated in Japan, with elevated serum soluble interleukin-2 receptor (sIL-2R) replacing negative tuberculin reaction. Therefore, we assessed the clinical utility of sIL-2R compared with two other common markers, angiotensin-converting enzyme (ACE) and lysozyme, in patients who visited the dermatology clinic. Data from 72 patients showed that sIL-2R was more sensitive than both ACE and lysozyme in supporting a diagnosis of sarcoidosis (52.8%) compared with ACE (29%) and lysozyme (26.4%). Additionally, the sIL-2R level was significantly higher in patients with multiple organ involvement and parenchymal infiltration. Patients with elevated sIL-2R levels had higher serum ACE and lysozyme levels, a higher incidence of pulmonary involvement, more severe chest radiographic stage and a high incidence of expression-specific signs by imaging analysis. Receiver-operator curve analysis showed that sIL-2R was a better marker at the threshold cut-off point compared with ACE and lysozyme for identifying patients with multiple organ involvement, detecting patients with pulmonary disease and parenchymal infiltration as well as predicting the presence of specific signs in the diagnosis of sarcoidosis. Moreover, the kinetics of sIL-2R levels correlated closely with clinical manifestations, in contrast to the modest changes of ACE and lysozyme levels during the follow-up period. In conclusion, sIL-2R may be considered a good marker for diagnosis and a potential indicator of disease activity.

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“…In line with previous works, we found that serum sIL‐2R levels were significantly higher than normal in patients with sarcoidosis (Fig. ).…”

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Serum soluble interleukin‐2 receptor level is more sensitive than angiotensin‐converting enzyme or lysozyme for diagnosis of sarcoidosis and may be a marker of multiple organ involvement

Nguyen

Kambe

Kishimoto

et al. 2017

The Journal of Dermatology

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“…After intravenous injection, it attaches to cells with transferrin receptors, such as macrophages and malignant cells. When used for the diagnosis of sarcoidosis, it is highly specific when multiorgan involvement is present, such as lymph nodes, lung and salivary glands 72. An abnormal gallium scan is a major diagnostic criterion for cardiac sarcoidosis, the intensity of uptake reflecting the degree of inflammation 73.…”

Section: Diagnostic Testsmentioning

confidence: 99%

“…It has also been used for monitoring response to therapy 75 76. Despite its advantages, gallium 67 scintigraphy is now less widely used because of its lower sensitivity,72 the difficulty of localising abnormalities unless coupled with SPECT-CT and a relatively high radiation burden of up to 15 mSv.…”

Section: Diagnostic Testsmentioning

confidence: 99%

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Cardiac sarcoidosis: diagnosis and management

Dubrey

Sharma

Underwood

et al. 2015

Postgraduate Medical Journal

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Cardiac sarcoidosis is one of the most serious and unpredictable aspects of this disease state. Heart involvement frequently presents with arrhythmias or conduction disease, although myocardial infiltration resulting in congestive heart failure may also occur. The prognosis in cardiac sarcoidosis is highly variable, which relates to the heterogeneous nature of heart involvement and marked differences between racial groups. Electrocardiography and echocardiography often provide the first clue to the diagnosis, but advanced imaging studies using positron emission tomography and MRI, in combination with nuclear isotope perfusion scanning are now essential to the diagnosis and management of this condition. The identification of clinically occult cardiac sarcoidosis and the management of isolated and/or asymptomatic heart involvement remain both challenging and contentious. Corticosteroids remain the first treatment choice with the later substitution of immunosuppressive and steroid-sparing therapies. Heart transplantation is an unusual outcome, but when performed, the results are comparable or better than heart transplantation for other disease states. We review the epidemiology, developments in diagnostic techniques and the management of cardiac sarcoidosis.

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Validation of systemic parameters for the diagnosis of ocular sarcoidosis

et al. 2021

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Clinical significance of the serum IL-2R level and Ga-67 scan findings in making a differential diagnosis between sarcoidosis and non-Hodgkin's lymphoma

Abstract: Measurement of sIL-2R levels was sometimes useful in differentiating between sarcoidosis and stage III/IV non-Hodgkin's lymphoma, staging non-Hodgkin's lymphoma, and predicting the presence of the panda and/or lambda sign in sarcoidosis patients.

Cited by 13 publications

References 8 publications

Serum soluble interleukin‐2 receptor level is more sensitive than angiotensin‐converting enzyme or lysozyme for diagnosis of sarcoidosis and may be a marker of multiple organ involvement

Serum soluble interleukin‐2 receptor level is more sensitive than angiotensin‐converting enzyme or lysozyme for diagnosis of sarcoidosis and may be a marker of multiple organ involvement

Cardiac sarcoidosis: diagnosis and management

Validation of systemic parameters for the diagnosis of ocular sarcoidosis

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