2013
DOI: 10.1111/hepr.12194
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Clinical significance of therapy using branched‐chain amino acid granules in patients with liver cirrhosis and hepatocellular carcinoma

Abstract: The liver is the major organ for the metabolism of protein, fat and carbohydrate. A nutritional approach is required in the treatment of cirrhosis, which is frequently complicated with protein-energy malnutrition. Several advanced treatment approaches for hepatocellular carcinoma (HCC) have been established in the past decade. HCC is often complicated by cirrhosis, so treatment of the underlying liver diseases is also necessary to improve the prognosis. Branched-chain amino acid (BCAA) granules were developed … Show more

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Cited by 37 publications
(45 citation statements)
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References 104 publications
(374 reference statements)
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“…Moreover, recent reports described that BCAA suppressed the incidence of HCC in cirrhotic patients with or without obesity and insulin resistance [4, 14, 15]. Supporting these findings, several mouse experiments demonstrated that BCAA reduced the incidence of DEN-induced HCC by improving insulin resistance [5], oxidative stress [16], and angiogenesis [7].…”
Section: Discussionmentioning
confidence: 78%
“…Moreover, recent reports described that BCAA suppressed the incidence of HCC in cirrhotic patients with or without obesity and insulin resistance [4, 14, 15]. Supporting these findings, several mouse experiments demonstrated that BCAA reduced the incidence of DEN-induced HCC by improving insulin resistance [5], oxidative stress [16], and angiogenesis [7].…”
Section: Discussionmentioning
confidence: 78%
“…Both tumor-related factors and liver function-related factors may be essential for the management of NBNC-HCC patients treated with SR. In that sense, branched-chain amino acid therapy for background liver disease may improve clinical outcomes (34). On the other hand, as for RFS, tumor number (P=0.002) and FIB-4 index (P=0.044) were found to be independent significant predictors and the presence of microvascular invasion had marginal significance (P= 0.068) in the multivariate analysis.…”
Section: Discussionmentioning
confidence: 92%
“…Several previous studies reported that pre-operative low serum albumin levels are an independent predictor of poor survival in ovarian cancer [35, 36]. Improvement in nutritional status is associated with better survival in ovarian cancer [14] and other tumors [37]. One of the reasons is that the presence of a systemic inflammatory response and the concomitant nutritional decline reduces patient tolerance to treatment toxicities and patient compliance with active treatment [38].…”
Section: Discussionmentioning
confidence: 99%