CLINICAL SIGNIFICANCE OF Toll2, Toll4, CD14, AND HLA-DR EXPRESSION ON THE MONOCYTES IN PATIENTS WITH SEPSIS

Лазанович, В. А.; Маркелова, Е. В.; Смирнов, Г. А.; Смолина, Т. П.

doi:10.15789/1563-0625-2015-3-221-228

Cited by 10 publications

(5 citation statements)

References 3 publications

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“…Mukherjee and colleagues showed that the expression of TLR2, or TLR4, and TLR5 is significantly expressed on the activated cMo and iMo, respectively [ 33 ]. Despite this study was carried out in vitro, which sets certain limitations on interpreting the results, elevation of expression of these receptors on monocytes was also found in vivo during SI [ 9 , 37 , 40 ].…”

Section: Change Of the Receptor Expression On Monocyte Subpopulatimentioning

confidence: 99%

“…Thus, EE is an example of translational research that helps to study the mechanisms of systemic inflammation and to estimate novel pharmacological interventions in humans in vivo [ 6 ]. EE can be regarded as an early step of the immune response to pathogen invasion [ 7 , 8 ], whereas the long-term changes in immune cells are studied on whole blood of patients with clinically confirmed sepsis [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Participation of Monocyte Subpopulations in Progression of Experimental Endotoxemia (EE) and Systemic Inflammation

Radzyukevich

Kosyakova

Прохоренко

2021

Journal of Immunology Research

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Systemic inflammation plays a crucial role in formation of various pathological conditions, including sepsis, burns, and traumas. The main effector cells participating in progression of systemic inflammation response and sepsis are monocytes, which regulate both innate and acquired immunity via phagocytosis, synthesis of cytokines and chemokines, antigen presentation, and lymphocyte activation. Thus, the monocytes are considered as a link between innate and acquired immunity. The monocyte subpopulations taken into consideration in the study essentially determine the progression of systemic inflammation and could serve as targets for therapeutic intervention. The complexity of the analysis of pathophysiology of systemic inflammation lies in its high variability conditioned by individual peculiarities of the patients and inflammation progression specifications. To overcome these limitation, model of experimental endotoxemia (EE) is used. The results of EE, in turn, cannot be directly extrapolated on patients with the systemic inflammatory response. This review is dedicated to discussing the role of monocyte subpopulations in progression of systemic inflammation/sepsis and EE.

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Section: Change Of the Receptor Expression On Monocyte Subpopulatimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Participation of Monocyte Subpopulations in Progression of Experimental Endotoxemia (EE) and Systemic Inflammation

Radzyukevich

Kosyakova

Прохоренко

2021

Journal of Immunology Research

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“…Накопленная информация об эффектах ТПР2 и ТПР9 в клетках и опухолях имеет неоднозначный характер. Механизмы ТПР-сигнальных реакций в опухолевых клетках включают синтез цитокинов, факторов пролиферации, апоптоза и клеточной дифференцировки, которые регулируются универсальным фактором транскрипции NF-kappaB [38,42,43]. В ТПР-индуцируемых процессах активно участвуют макрофаги и дендритные клетки, реакции которых подвержены иммуносупрессии со стороны опухолевых факторов.…”

Section: заключениеunclassified

“…Было высказано предположение, что причиной такой двойственности эффектов бактериальных ТПР (липополисахарид -лиганд ТПР4, флагеллин -лиганд ТПР5 и липопротеины -лиганды ТПР2) может [41,42]. Раскрытие механизмов двойственного характера действия ТПР на клетках опухолей разной локализации имеет ключевое значение для эффективного использования агонистов ТПР в терапии онкологических заболеваний.…”

Section: Introductionunclassified

The different roles of toll-like receptors in oncotherapy

Трещалина

Михайлова

Киселевский

2019

Rossijskij bioterapevtičeskij žurnal

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В обзоре рассмотрены и проанализированы данные литературы о функциях семейства толл-подобных рецепторов (ТПР), значимых для опухолевого процесса, кратко отражены такие важные аспекты, как строение ТПР, механизмы внутриклеточной передачи сигнала, известные специфические лиганды и агонисты ТПР. Кроме того, описаны эффекты воздействия на различные ТПР с точки зрения влияния на рост самой опухоли и реакций клеточного иммунитета. Приведено сравнение неоднозначных результатов экспериментального изучения и клинического применения агонистов и антагонистов ТПР. Сделан вывод о необходимости получения информации об отсутствии стимуляции опухолевого роста in vivo агонистов ТПР на этапе доклинического изучения.

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“…Sepsis is the most serious complication of infectious process. The mortality from the sepsis makes not less than 22,2 to 100 000 population and it depends on original resistance of an organism to the infection, age, sex accompanying pathology, system activity including a regulation of homeostasis from functional activity of endotheliocytes [1,2,3]. The endothelial dysfunction (ED) is an imbalance between the mediators providing an ideal current of all endothelial dependent workflow.…”

mentioning

confidence: 99%

Pharmacological Efficiency of Statins and L-Norvalin at an Endotoxin-Induced Endothelial Dysfunction

Ivlitskaya¹,

Корокин²,

Локтионов³

2016

RR.P and CP

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Abstract. In the animals with endotoxin-induced endothelial dysfunction there were imbalance of contractile response of vessels wall observes when carrying out functional tests, increase of coefficient of endothelial dysfunction, decrease in contractility of a myocardium, activation processes of peroxidation of lipids and decreased activity of antioxidant systems, level of stable metabolites of nitrogen oxide. On extent of decrease in corrective effects on indicators of functional activity of a vessel wall, contractility of a myocardium, oxidatic indicators and level of stable metabolites of nitrogen oxide are studied preparations settle down in the following sequence: L-norvalin and rozuvastatin (coefficient of endothelial dysfunction -1,2±0,1) → Lnorvalin and simvastatin (coefficient of endothelial dysfunction -1,5±0,1) → rozuvastatin (coefficient of endothelial dysfunction -1,6±0,1) → L-norvalin (coefficient of endothelial dysfunction -1,7±0,2) → symvastatin (coefficient of endothelial dysfunction -2,0±0,2).

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CLINICAL SIGNIFICANCE OF Toll2, Toll4, CD14, AND HLA-DR EXPRESSION ON THE MONOCYTES IN PATIENTS WITH SEPSIS

Cited by 10 publications

References 3 publications

Participation of Monocyte Subpopulations in Progression of Experimental Endotoxemia (EE) and Systemic Inflammation

Participation of Monocyte Subpopulations in Progression of Experimental Endotoxemia (EE) and Systemic Inflammation

The different roles of toll-like receptors in oncotherapy

Pharmacological Efficiency of Statins and L-Norvalin at an Endotoxin-Induced Endothelial Dysfunction

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