Clinical Sings and Symptoms of Polyvascular Disease in Coronary Artery Disease Patients of Different Age Groups

Leukocyte Telomere Length as a Molecular Biomarker of Coronary Heart Disease

“…Yakhontov et al [ 64 ] studied the relationship between LTL in men with stable angina I-III functional classes according to the Canadian Cardiovascular Society classifications [ 67 ] in different age groups: the middle-aged group (median age 52 [46.5; 55] years) and the elderly group (median age 64 [62; 67] years). The authors found no statistically significant differences in LTL in patients with stable angina pectoris as a function of mean and old age ( p -value = 0.058) [ 63 ].…”

“…The authors found no statistically significant differences in LTL in patients with stable angina pectoris as a function of mean and old age ( p -value = 0.058) [ 63 ]. Another study by these authors [ 64 ] examined LTL in young (median age 52 [46.5; 55] years) and middle-aged (median age 64 [62; 67] years) men with arterial hypertension and with stable angina I-III functional classes with and without EVA. The criteria for the inclusion of patients in the subgroup with EVA were a young age of arterial hypertension debut (before 45 years), a young age of CAD debut (before 45 years), and increased vascular wall stiffness according to the cardio-ankle vascular index (according to sonography).…”

“…We demonstrated that in studies of the mean relative LTL in young, middle-aged, and elderly adults, the value of this molecular biomarker decreases not only in relation to the physiological biological aging of the human body but also in relation to the premature development of stable CAD [ 64 ] and the early development of AMI [ 60 ]. At the same time, the most convincing results were obtained in studies of relative LTL in middle-aged and elderly patients with stable CAD [ 55 , 58 , 59 , 61 , 63 , 64 , 65 ]. It seems important from a practical point of view because patients with stable CAD and with shortened relative LTL can have unfavorable prognoses concerning general mortality [ 75 ].…”