Clinical spectrum of community-acquired acute kidney injury: A prospective study from central India

Goswami, Shraddha; Raju, BhavaniM; Purohit, Ashish; Pahwa, Naresh

doi:10.4103/1319-2442.279945

Cited by 4 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Acute tubulointerstitial nephritis (ATIN) is a common cause of acute kidney injury (AKI) [1], representing 15-25% of cases [2,3] where the indication for renal biopsy was AKI. However, it is less common than other causes of AKI such as hypoperfusion or sepsis [4].…”

Section: Introductionmentioning

confidence: 99%

Hematuria Is Associated with More Severe Acute Tubulointerstitial Nephritis

Esteras

Fox

Geddes

et al. 2020

JCM

View full text Add to dashboard Cite

Acute tubulointerstitial nephritis (ATIN) is a common cause of acute kidney injury. Although haematuria is a risk factor for the development of renal disease, no previous study has analyzed the significance of haematuria in ATIN. Retrospective, observational analysis of 110 patients with biopsy-proven ATIN was conducted. Results: Haematuria was present in 66 (60%) ATIN patients. A higher percentage of ATIN patients with haematuria had proteinuria than patients without haematuria (89.4% vs. 59.1%, p = 0.001) with significantly higher levels of proteinuria (median (interquartile range) protein:creatinine ratio 902.70 (513–1492) vs. 341.00 (177–734) mg/g, p <0.001). Moreover, those patients with more haematuria intensity had a higher urinary protein:creatinine ratio (1352.65 (665–2292) vs. 849.60 (562–1155) mg/g, p = 0.02). Those patients with higher proteinuria were more likely to need renal replacement therapy (22.7 vs. 0%, p = 0.03) and to suffer relapse (4 vs. 0%, p = 0.03). At the end of follow up, haematuric ATIN patients had higher serum creatinine levels (3.19 ± 2.91 vs. 1.91 ± 1.17 mg/dL, p = 0.007), and a trend towards a higher need for acute dialysis (7 vs. 1%, p = 0.09) and renal replacement therapy (12.1 vs. 2.3%, p = 0.12). Haematuria is common in ATIN and it is associated with worse renal function outcomes.

show abstract

Section: Introductionmentioning

confidence: 99%