Clinical Status of Furosemide on Liver Cirrhosis with Portal Hypertension and Ascites

Thapaliya, Kailash; Bhandary, Apeksha; Basnet, Sangharshila; Aryal, Bijay

doi:10.3126/jcmc.v3i1.8470

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…per se In the present study, pretreatment with furosemide (25 and 50 mg/kg) produced significant reductions in acute immobilization or foot-shock stress-induced behavioral alterations in mice. Furosemide is a selective inhibitor of NKCC and is clinically employed in patients with mild to severe congestive heart failure (Francis et al 1985) and portal hypertension (Thapaliya et al 2013) due to its diuretic effect. Apart from the well documented diuretic actions of NKCC blockers, the preclinical studies have also suggested their important role in attenuating cerebral ischemia-induced neuronal injury (Roberts et al 1987), epilepsy (Oriaifo et al 2012), neuropathic pain (Granados-Soto et al 2005), and myocardial infarction (Ternacle et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Investigating the stress attenuating potential of furosemide in immobilization and electric foot-shock stress models in mice

Kaur

Bali

Singh

et al. 2015

Naunyn-Schmiedeberg's Arch Pharmacol

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The present study was designed to investigate the antistress effect of furosemide (sodium potassium chloride co-transporter inhibitor) in immobilization and foot-shock stress-induced behavioral alterations in the mice. Acute stress was induced in Swiss albino mice either by applying electric foot shocks of 0.6-mA intensity of 1-s duration with 30-s inter-shock interval for 1 h or immobilizing for 150 min. The acute stress-induced behavioral changes were assessed by using actophotometer, hole board, open-field, and social interaction tests. Biochemically, the corticosterone levels were estimated in the serum as a biomarker of hypothalamus-pituitary-adrenal (HPA) axis. Acute stress resulted in the development of behavioral alterations and elevation of the corticosterone levels. Intraperitoneal administration of furosemide (25 and 50 mg/kg) significantly attenuated immobilization and foot-shock stress-induced behavioral changes along with normalization of the corticosterone levels. It may be concluded that furosemide produces beneficial effects in reestablishing the behavioral and biochemical alterations in immobilization and foot-shock-induced acute stress in mice.

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Section: Discussionmentioning

confidence: 99%

Investigating the stress attenuating potential of furosemide in immobilization and electric foot-shock stress models in mice

Kaur

Bali

Singh

et al. 2015

Naunyn-Schmiedeberg's Arch Pharmacol

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“…Cirrhosis occurs when the normal structure of the liver is disrupted by bands of scar tissue. One of the normal functions of the liver is to filter blood returning to the heart from the digestive system.In this cirrhosis condition, the presence of scar tissue causes increased resistance to blood flow through the liver, which leads to the development of high pressure in the veins that drain blood into the liver ,resulting in a condition called 'portal hypertension' [3]. Portal hypertension can lead to life-threatening hemorrhage, ascites, and encephalopathy.…”

Section: Introductionmentioning

confidence: 99%

Case report on chronic liver disease with portal hypertension with massive ascites

Pala

Anusha

Narendra

2020

World Journal of Current Med and Pharm Research

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Portal hypertension is an increase in the blood pressure within the system of veins called the Hepatic portal venous system. Veins coming from the stomach, intestine, spleen, and pancreas merge into the portal vein, which then branches into smaller vessels and travels through the liver. If the vessels in the liver are blocked due to liver damage, blood cannot flow properly through the liver. As a result, high pressure in the portal system develops. This increased pressure in the portal vein may lead to the development of large, swollen veins (varices) within the esophagus, stomach, rectum, or umbilical area (belly button). Varices can rupture and bleed, resulting in potentially life-threatening complications. We present a case of portal hypertension with massive ascites- A 43-year-old female was admitted with chief complaints of abdominal distension, abdominal pain, and shortness of breath prior to 15 days of presentation and the symptoms were gradually progressive in nature. Her past medical history reveals she had similar complaints in the past and known cases of chronic liver disease. After admission, she has been diagnosed with portal hypertension along with Refractory ascites. The management included antihypertensives and human albumin, A high protein diet with salt and fluid restrictions, large-volume paracentesis procedure was carried out daily.

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Clinical Status of Furosemide on Liver Cirrhosis with Portal Hypertension and Ascites

Cited by 2 publications

References 6 publications

Investigating the stress attenuating potential of furosemide in immobilization and electric foot-shock stress models in mice

Investigating the stress attenuating potential of furosemide in immobilization and electric foot-shock stress models in mice

Case report on chronic liver disease with portal hypertension with massive ascites

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