Clinical Studies of Induction Agents Xxviii: A Further Comparison of Venous Complications Following Thiopentone, Methohexitone and Propanidid

O'Donnell, Jane; Hewitt, J.C.; Dundee, John W.

doi:10.1093/bja/41.8.681

Cited by 15 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pain on injection or movements are also associated with other drugs currently administered during induction and maintenance of anaesthesia (10–14). To eliminate any confounding contribution of the IV cannula itself or other drugs given intravenously during anaesthesia, the patients received rocuronium through a 20‐gauge IV cannula exclusively used for this injection and immediately removed in the PACU.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous movements, local reactions and pain on injection of rocuronium

Mencke

Beerhalter

Fuchs‐Buder

2001

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Spontaneous movements, local reactions and pain on injection of rocuronium

Mencke

Beerhalter

Fuchs‐Buder

2001

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

show abstract

“…Comparing the findings from the use of 8 per cent solution with those reported by Hewitt and associates (1966) and O'Donnell, Hewitt and Dundee (1969), it would appear that this concentration causes a higher incidence of venous sequelae than do clinical doses of thiopentone or methohexitone, but that the incidence is similar to that noted after injection of propanidid. moderate hypocapnia should be maintained after discontinuing first the halothane and subsequently the nitrous oxygen preferably until the pre-operative level of consciousness has been regained.…”

Section: Discussionmentioning

confidence: 51%

Clinical Studies of Induction Agents: Xxx: Venous Sequelae Following Ethanol Anaesthesia

Isaac

Dundee

1969

British Journal of Anaesthesia

Self Cite

View full text Add to dashboard Cite

The effect of a rapid infusion of 5-10 per cent (w/v) solution of ethanol on veins was studied in about 400 patients. The infusion of up to 550 ml was given rapidly over 4-5 minutes. An unacceptably high incidence of pain and of sequelae followed the use of 7 and 10 per cent (w/v) solutions while 5 and 6 per cent (w/v) carried the lowest incidence of side effects. These latter were too dilute for use in intravenous anaesthesia, and the 8 per cent w/v (10 per cent v/v) caused no higher incidence of sequelae than propanidid. Therefore it is acceptable for clinical use.

show abstract

“…lorazepam was studied in patients who received no other drug through the same vein and in whom the 4-mg ml" 1 solution was injected without dilution. These patients were visited on the 2nd or 3rd day after operation and the results are presented according to the method described by Hewitt and others (1966) and O'Donnell, Hewitt and Dundee (1969). This gives the incidence of phlebitis, thrombosis and thrombophlebitis.…”

Section: Venous Irritationmentioning

confidence: 99%

Studies of Drugs Given Before Anaesthesia Xxvi: Lorazepam

Dundee¹,

Lilburn²,

Nair³

et al. 1977

British Journal of Anaesthesia

Self Cite

View full text Add to dashboard Cite

Lorazepam has been studied as preanaesthetic medication given by mouth, i.m. and i.v. Sediation and side-effects and the incidence of anterograde amnesia in patients having a standard operation under methohexitone-nitrous oxide-oxygen anaesthesia were assessed. In a preliminary study of three i.m. (2-, 4- and 8-mg) and six oral (1-,2-,2.5-,4-,5- and 8-mg) doses, the optimum dose was found to be 4 mg for patients with an average weight of 60 kg. This dose was studied in detail when given by all three routes and compared with the commercially available 2.5- and 5-mg tablets. Even when given i.v., there was a delay of 30-40 min in the onset of maximum sedative effect and drowsiness persisted for at least 4 h. Although the onset of action by i.m. injection was slightly faster than when the drug was given by mouth this advantage was more than offset by the high frequencies of pain at the site of injection and restlessness which persisted for 20-40 min. Oral lorazepam in doses of 2.5-5.0 mg was a reliable, effective sedative which could be recommended for routine preanaesthetic medication, provided rapid recovery was not essential. Its soporific effect was accompanied by an appreciable incidence of anterograde amnesia.

show abstract

Clinical Studies of Induction Agents Xxviii: A Further Comparison of Venous Complications Following Thiopentone, Methohexitone and Propanidid

Cited by 15 publications

References 0 publications

Spontaneous movements, local reactions and pain on injection of rocuronium

Spontaneous movements, local reactions and pain on injection of rocuronium

Clinical Studies of Induction Agents: Xxx: Venous Sequelae Following Ethanol Anaesthesia

Studies of Drugs Given Before Anaesthesia Xxvi: Lorazepam

Contact Info

Product

Resources

About