Clinical studies of neuroinflammatory mechanisms in schizophrenia

Watkins, Crystal C.; Andrews, Sarah R.

doi:10.1016/j.schres.2015.07.018

Cited by 75 publications

(57 citation statements)

References 134 publications

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“…Thus, the results suggested that smoking is an important contributor to the altered immune system in patients with chronic schizophrenia [33]. In addition, various abnormalities in the immune system are associated with schizophrenia [34][35][36][37]. For example, two recent metaanalyses have shown cytokine alterations in schizophrenic patients.…”

Section: Symptoms and Lipid Profiles In Smokers Versus Non-smokersmentioning

confidence: 99%

Smoking and Serum Lipid Profiles in Schizophrenia

Tan

et al. 2016

Neurosci. Bull.

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Schizophrenia is associated with a high prevalence of cigarette-smoking and abnormal lipid profiles. The purpose of this study was to determine whether the profiles differ between schizophrenic smokers and non-smokers and whether the lipid profiles are related to psychopathological symptoms. Serum lipid profiles were measured in 130 male inpatients with DSM-IV-defined schizophrenia: 104 smokers and 26 non-smokers. Symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS). Our results showed that positive PANSS symptoms were fewer in smokers than in non-smokers, while the negative symptoms were fewer in those who smoked more cigarettes. Total protein and globulin levels were significantly lower in the smokers than in the non-smokers. However, there was no significant difference in total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol, apolipoprotein A1, or apolipoprotein B between the smokers and non-smokers. However, the PANSS positive subscale had a significant negative correlation with the HDL-c levels (a protective factor) in the smokers but not in the non-smokers. Our findings suggest that schizophrenic patients who smoke have fewer psychotic symptoms, but contrary to expectation, smoking does not alter lipid profile levels.

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Section: Symptoms and Lipid Profiles In Smokers Versus Non-smokersmentioning

confidence: 99%

Smoking and Serum Lipid Profiles in Schizophrenia

Tan

et al. 2016

Neurosci. Bull.

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“…3) Inflammation triggered by innate immunity has been shown to play a role in other neuropsychiatric diseases, such as depression and schizophrenia, especially in the onset and early stages [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Interleukin-1β/Interleukin10 Ratio Produced by Monocytes as a Biomarker of Neuroinflammation in Autism

Jyonouchi¹,

Geng²,

Buyske³

2017

J Clin Cell Immunol

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“…It has been well-established in recent times that schizophrenia can no longer be treated as an exclusively psychological or psychiatric phenomenon, since its pathophysiology involves a combination of neurological and psychiatric phenomena. 1 Therefore, it is more appropriate to study it as a neuropsychiatric disorder. 2 The parts of the brain most commonly involved in schizophrenia are the forebrain, the hindbrain, and the limbic system.…”

Section: Introductionmentioning

confidence: 99%