Clinical studies on recurrence of colorectal cancer.

Ike, Hideyuki; Ohki, Shigeo; Ohmi, Yoshihiro; Tsujinaka, Yasunobu; Tajima, Shigeru; Iida, Akira; Jyo, T; Yamaoka, Hiroyuki; Furushima, Kaoru; Ohde, Naohiro; Tsuchiya, Shuji

doi:10.5833/jjgs.20.1723

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“…Hence, these guidelines informed our selection of CT scans of the chest, abdomen, and pelvis with IV contrast. The most common site of local and distant recurrence is reportedly the liver [ 17 ], and many liver metastases in Japan reportedly occur within a year of surgery [ 18 ]. Early prediction of recurrence may make resection possible; hence, we limited our investigation of recurrence to the scope of a year.…”

Section: Methodsmentioning

confidence: 99%

The metabolic parameters based on volume in PET/CT are associated with clinicopathological N stage of colorectal cancer and can predict prognosis

et al. 2021

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Background A combination of positron emission tomography and computed tomography (PET/CT) is an important modality for the diagnosis of carcinoma. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) have been reported as metabolic parameters in PET/CT since the late 1990s, and they are expected to be useful in diagnosing diverse cancers and as prognostic biomarkers. We evaluated the potential of these parameters in the prognosis of colorectal cancer (CRC) by comparing them with conventional parameters, including the maximum standardized uptake value (SUVmax). We enrolled 84 patients who underwent surgery for CRC without distal metastasis between April 2015 and April 2019. SUVmax, MTV, and TLG were measured by 18F-fluorodeoxyglucose (FDG)-PET/CT. To find an optimal threshold value related to prognosis, the volume of interest in the primary carcinoma was measured at fixed relative and absolute thresholds based on SUVmax (30%, 40%, and 50%; 2.5, 3.0, and 3.5, respectively), tumor-to-liver standardized uptake ratios, TLR (1.0, 1.5, and 2.0), and SUV normalized to lean body mass, SUL (2.0, 2.5, and 3.0). After classifying the patients into two groups according to pathological N stage, the optimal threshold values of all metabolic parameters were compared between groups using a non-parametric comparison test. Result The most suitable thresholds for MTV were a SUVmax of 3.5 and a TLR 2.0. TLG with a SUVmax value of 40% showed the most significant difference. The MTV standard uptake ratio of 2.0 was significantly associated with pathological N stage. Conclusion Our results suggest that an MTV TLR 2.0 on PET/CT reflects pathological N stage in local patients with CRC.

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Section: Methodsmentioning

confidence: 99%