Clinical Study of Pancytopenia

Abstract

Introduction: Pancytopenia is a common and alarming condition encountered by clinicians. We had studied the clinical presentation, laboratory investigations and various etiologies of Pancytopenia. Material and Methods: Study was carried out in a tertiary care centre in western India. A total of 102 patients fulfilling the criteria of pancytopenia were enrolled and studied. Results and conclusion: Megaloblastic anemia was commonest cause of pancytopenia. Easy fatigability and pallor were commonest symptoms and signs respectively. Maximum bleeding manifestations were seen in aplastic anemia and Myelodysplastic syndrome. Available online at: www.ijmrr.in 1557 | P a g e Common over the counter drugs like ibuprofen can also cause pancytopenia. Organophosphorus exposure, cytotoxic drugs, chloramphenicol, methotrexate, phenytoin are commonly implicated [21].Pancytopenia in Indian setting is mostly due to benign because mainly megaloblastic anemia secondary to B12 deficiency caused either by dietary deficiency or treatable condition for example tuberculosis. Emphasis on dietary awareness and supplements wherever required may thus reduce the incidence of pancytopenia and related problems.

Clinico-hematological evaluation in cases of pancytopenia at tertiary care centre: largest cross-sectional study

“…12 Also similar study carried out by Vaidya et al found the most common age group was 21-30 years comprising 33.24 % of cases. 13 Similarly our results of age and sex ratio were comparable with other studies carried out by Thakkar et al, Manzoor et al, Yadav et al and Zeeshan et al [14][15][16][17] The study carried out by Lakhey et al in Nepal found weakness was the predominant presenting clinical feature in 73.9% cases. 18 Khodke et al studied 50 pancytopenia cases and found commonest presenting complaint was fever (40%) followed by weakness (30%) and bleeding manifestations (20%).…”