Clinical study on effect of Shenfu injection treating cancer-relatedfatigue of patients with advanced carcinoma

Gu, Yechun; Xu, Hongbo; Zhao, Maosen

doi:10.4268/cjcmm20100725

CJCMM

2010

DOI: 10.4268/cjcmm20100725

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Clinical study on effect of Shenfu injection treating cancer-relatedfatigue of patients with advanced carcinoma

Yechun Gu

Hongbo Xu²,

Maosen Zhao³

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Cited by 5 publications

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Effect of Shenfu injection on immune function of mice bearing Lewis lung sarcoma with chemotherapy

Luo

Wang

et al. 2016

Tumor Biol.

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Chemotherapy damages immune system and has a lot of side effects. In this study, we investigate the function of Shenfu injection to reduce these unfavorable effects induced by chemotherapy on mice bearing Lewis lung sarcoma. Mice inoculated with Lewis lung sarcoma cells were divided into five groups: Lewis lung sarcoma control group, cyclophosphamide (CTX) group, and Shenfu injection (high, moderate, and low dose) + CTX group. After a 14-day treatment, the counting of peripheral blood cells, CD3+, CD4+, and CD8+ T lymphocytes were done, immunoglobulin (Ig) was measured, coefficients of spleen and thymus were calculated, and spleen T cell proliferation was evaluated in vitro. The CD4+/CD8+ and CD3+ T cells in high- and moderate-dose Shenfu groups were more than the CTX group (p < 0.05); spleen T cell proliferation of mice in high-dose Shenfu + CTX group is more prominent than the CTX group (p < 0.05); coefficients of spleen and thymus, WBC, and platelet (PLT) counting of mice in the CTX group were lower than control and high and moderate dose Shenfu + CTX groups. The level of serous IgG and IgM of all test groups shows no significant difference. Shenfu injection can improve cellular immune function and reduce myolosuppression of mice delivered with chemotherapy.

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Effect of Shenfu injection on immune function of mice bearing Lewis lung sarcoma with chemotherapy

Luo

Wang

et al. 2016

Tumor Biol.

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Clinical Aspects of Aconitum Preparations

Tai

El-Shazly

et al. 2015

Planta Med

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Aconitum, also known as monkshood, wolfʼs bane, or devilʼs helmet, has been widely used in folk medicine in China, India, and certain parts of Europe [1-4]. The genus Aconitum (Ranunculaceae) comprises 300 species distributed all over the world [5]. The most common species are Aconitum carmichaelii Deb. and Aconitum kusnezoffii Rchb. in China, Aconitum japonicum Thunb. in Japan, Aconitum napellus L. in Europe, Aconitum ferox Wall. ex Ser. in India, and Aconitum noveboracense A. Gray ex Coville in the United States [5]. Several classes of secondary metabolites, especially alkaloids, have been isolated from different Aconitum sp. [6]. The type of the isolated major alkaloids may vary depending on the species such as aconitine, hypaconitine, and mesaconitine from A. carmichaelii, aconitine from A. napellus, hypaconitine from A. septentrionale Koelle, mesaconitine from A. kusnezoffii, bikhaconitine from A. ferox, talatisamine from A. kongboense Lauener, atisine from A. anthora L., and A. heterophyllum Wall. ex Royle, and lycaconitine from A. vulparia Rchb. [6]. Several isoquinoline alkaloids and phenethylamine derivatives have also been isolated, such as higenamine from A. japonicum, magnoflorine from A. vulparia and A. napellus, coryneine from A. carmichaelii, and N-methyl adrenaline from A. nasutum Fisch. ex Rchb. [6]. Lipo-alkaloids including lipoaconitines, lipomesaconitines, lipodeoxyaconitines, and lipohypaconitines were also isolated [7, 8]. The efficacy of Aconitum sp. in resolving critical clinical conditions has been proven by doctors practicing traditional Chinese medicine (TCM) and Ayurvedic medicine for centuries. However, the long history of Aconitum sp. misuse in homicide cases has shaken the faith in the potential safe application of this herb in therapy [9, 10]. The recent developments in analytical techniques which can identify and determine the concentrations of toxic compounds in herbal products with impressive accuracy and reliability have rekindled the interest in Aconitum preparations [1, 5, 6, 11, 12].

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Effect of Traditional Chinese Medicine Injection on Cancer‐Related Fatigue: A Meta‐Analysis Based on Existing Evidence

Huang

Zhang²,

Fan

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background and Objective. Cancer-related fatigue (CRF) is a common and painful side effect for cancer patients. The treatment of CRF by traditional Chinese medicine injection (TCMJ) is controversial. We conducted a meta-analysis and systematic review to evaluate the effect of TCMJ on CRF, with a view to providing some guidance for clinical application. Methods. We systematically searched randomized controlled studies reported through March 2020 in PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science, China Biomedical Literature Database (CBM), the China National Knowledge Infrastructure (CNKI), Wanfang, and VIP databases. Two investigators independently screened the studies according to the predetermined criteria, extracted data, and evaluated the bias risk of the included studies, using RevMan5.3 software. Results. Twelve studies enrolling 1005 participants were included in this systematic review. We found that TCMJ could improve the clinical efficacy of CRF patients (RR = 1.24, 95% CI: 1.05–1.46, P = 0.01 ), ameliorate fatigue status (RR = 1.44, 95% CI: 1.27–1.65, P < 0.00001 ), and improve quality of life (MD = 8.34, 95% CI: 3.31–13.37, P = 0.001 ), but there was no statistical significance in the fatigue score (MD = −1.10, 95% CI: −2.23–0.04, P = 0.06 ). Referring to the number of adverse events, the safety of TCMJ was good. Subgroup analysis showed that TCMJ could improve clinical efficacy, fatigue, and quality of life in a short time (≤4 weeks). Among them, tonic TCMJ could improve the clinical efficacy. TCMJ had advantages in improving fatigue of lung cancer and gastric cancer. In addition, life quality of lung cancer patients improved significantly. Conclusion. Current research evidence showed that TCMJ could improve the clinical efficacy, fatigue status, and life quality of patients with CRF. In addition, we found that TCMJ could improve the clinical efficacy of CRF patients in a short period of time. Tonic TCMJ could improve the clinical efficacy, but heat-clearing TCMJ could not. Life quality and fatigue status of lung cancer patients improved significantly. However, due to the sample size and quality of the included studies, the results of this analysis should be treated with caution. The above conclusions still need to be verified by more large-sample and high-quality randomized controlled trials.

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Clinical study on effect of Shenfu injection treating cancer-relatedfatigue of patients with advanced carcinoma

Cited by 5 publications

References 0 publications

Effect of Shenfu injection on immune function of mice bearing Lewis lung sarcoma with chemotherapy

Effect of Shenfu injection on immune function of mice bearing Lewis lung sarcoma with chemotherapy

Clinical Aspects of Aconitum Preparations

Effect of Traditional Chinese Medicine Injection on Cancer‐Related Fatigue: A Meta‐Analysis Based on Existing Evidence

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