Clinical Subtypes in Children with Attention-Deficit Hyperactivity Disorder According to Their Child Behavior Checklist Profile

Katsuki, Daisuke; Yamashita, Hiroshi; Yamane, Kenichi; Kanba, Shigenobu; Yoshida, Keiko

doi:10.1007/s10578-020-00977-8

Cited by 21 publications

(22 citation statements)

References 43 publications

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“…However, we still lack quantitative comparisons of multiple dimensions of psychopathology across several SCAs [10]. Such approaches have proved fruitful in other clinical contexts (e.g., the CBCL-Dysregulation Pro le [CBCL-DP; [21,22]]; [23][24][25][26][27][28] -which strongly motivates pursuing their application in SCA research.…”

Section: Introductionmentioning

confidence: 99%

Patterns of Psychopathology and Cognition in Sex Chromosome Aneuploidy

Rau

Whitman

Schauder

et al. 2021

Preprint

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Background Sex chromosome aneuploidies (SCAs) are a collectively common family of genetic disorders that increase risk for neuropsychiatric and cognitive impairment. Beyond being important medical disorders in their own right, SCAs also offer a unique naturally-occurring model for X- and Y-chromosome influences on the human brain. However, it remains unclear if (i) different SCAs are associated with different profiles of psychopathology, and (ii) the notable interindividual variation in psychopathology is related to co-occurring variation in cognitive ability. Methods We examined scores for 11 dimensions of psychopathology [Child/Adult Behavior Checklist (CBCL)] and general cognitive ability [full-scale IQ (FSIQ) from Wechsler tests] in 110 youth with varying SCAs (XXY = 41, XYY = 22, XXX = 27, XXYY = 20) and 131 typically developing controls (XX = 59, XY = 72). Results All SCAs were associated with elevated CBCL scores across several dimensions of psychopathology, but social and attentional functioning were particularly sensitive to carriage of a supernumerary Y-chromosome. There was marked variability in CBCL scores within each SCA group, which generally correlated negatively with IQ, but most strongly so for social and attentional difficulties. These correlations showed subtle differences as a function of SCA group and CBCL scale. Conclusions There is domain-specific variation in psychopathology across SCA groups, and domain-specific correlation between psychopathology and IQ within SCAs. These findings (i) help to tailor clinical assessment of this common and impactful family of genetic disorders, and (ii) suggest that dosage abnormalities of X- and Y-linked genes impart somewhat distinct profiles of neuropsychiatric risk.

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Section: Introductionmentioning

confidence: 99%

Patterns of Psychopathology and Cognition in Sex Chromosome Aneuploidy

Rau

Whitman

Schauder

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…Katsuki et al used the CBCL to help identify subgroups of ADHD children defined by specific patterns of emotional and behavioral symptoms. Cluster analysis yielded a solution with four distinct subgroups: 1) “high internalizing/externalizing”, 2) “inattention and internalizing”, 3) “aggression and externalizing” with a high rate of comorbid oppositional defiant disorder and conduct disorder, and 4) “less psychopathology” with low scores on all syndrome scales ( 19 ). While noteworthy, these findings provide little guidance for clinicians assessing children with ADHD on how to best approach the management of a particular child with ADHD referred to clinical care.…”

Section: Introductionmentioning

confidence: 99%

Can the Child Behavior Checklist (CBCL) help characterize the types of psychopathologic conditions driving child psychiatry referrals?

Biederman

DiSalvo

Vaudreuil

et al. 2020

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology

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Background: Little is known about the scope of problems driving referrals to child and adolescent psychiatry services. Identifying the full range of mental disorders affecting a particular child can help triage the child to a clinician with the appropriate level of expertise. The Child Behavior Checklist (CBCL) is an easy-to-use assessment tool that may provide invaluable information regarding the severity of the presenting complaints and also aid in the referral process. Objective: To assess the utility of the CBCL to gain insights into the type of clinical problems driving referrals of youth to an outpatient pediatric psychiatry clinic. Method: The sample consisted of 418 newly referred youth 4-18 years of age of both sexes. Parents completed the CBCL assessing psychopathology and competence. Rates of patients with elevated T-scores on each scale were calculated for the whole group and stratified by sex and age (≤12 versus >12). Results: The CBCL identified high rates of psychopathology affecting referred youth. It also provided information on the type of suspected disorders affecting a particular child as well as their severity, critical information to guide likely differing clinical needs and therapeutic approaches. It also helped identify a high number of youth affected with multiple psychopathological conditions, likely to require a high level of clinical attention. Overall, males were significantly more impaired than females but there were no major differences between children and adolescents. Conclusions: The CBCL can aid in the identification of individual and comorbid mental disorders affecting youth seeking mental health services by providing specific information about the presence and the severity of specific suspected disorder. These findings have implications for prioritizing scarce resources in child mental health and for improved consideration of the complexity of clinical presentations to pediatric psychiatry programs of any type.

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“…They also showed high levels of emotional-behavioral dysregulation, and their mothers showed the greatest psychopathological risk. Previous studies have shown that early food avoidant behaviors may be associated with impulsivity behaviors in preschooler children [ 15 ] and hyperactive symptoms over time [ 34 , 35 ], and recent studies by Peyre and colleagues [ 59 ] and by Katsuki and colleagues [ 60 ] have evidenced a key role played by CBCL DP in ADHD. The present study also suggested that the I/I subtype may be a higher risk for dysregulation problems, in line with recent literature [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

DAT1 and Its Psychological Correlates in Children with Avoidant/Restrictive Food Intake Disorder: A Cross-Sectional Pilot Study

Cimino

Marzilli

Babore

et al. 2021

Behavioral Sciences

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International research has underlined the role played by children’s and maternal psychopathological symptoms on the onset of avoidant/restrictive food intake disorder (ARFID) in early childhood. No study has considered the possible interplay between children’s dopamine transporter (DAT1) genotype and methylation, dysregulation problems and maternal psychopathological risk. This study aimed to investigate the complex relationship between these variables, considering the possible mediation role played by children’s DAT1 methylation on the relationship between mothers’ psychopathological risk and children’s dysregulation problems, moderated by children’s DAT1 genotype. Our sample consisted of 94 early children and their mothers, divided into four subgroups, based on children’s ARFID subtypes (irritable/impulsive (I/I), sensory food aversions (SFA), post-traumatic feeding disorders subtypes (PTFD), and a non-clinical group (NC)). We addressed children’s dysregulation problems and maternal psychopathological risk, and collected children’s DNA through buccal swabs. Results showed that children’s 9/x genotype was associated with PTFD and NC groups, whereas the 10/10 genotype was associated with the SFA group, with large effect size. There were significant large differences in the study groups on children’s DAT1 total methylation, children’s dysregulation problems, and maternal psychopathological risk. Children’s DAT1 methylation did not mediate the relationship between mother’s psychopathological risk and children’s dysregulation problems, but there was a significant large direct effect. Children’s 9/x genotype moderated the relationship between maternal psychopathological risk and children’s DAT1 methylation but, respectively, with a large and small effect. Our pilot study suggested that the relationship between children’s DAT1 genotype and methylation, dysregulation problems, and maternal psychopathological risk has a crucial contribution to ARFID.

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Clinical Subtypes in Children with Attention-Deficit Hyperactivity Disorder According to Their Child Behavior Checklist Profile

Cited by 21 publications

References 43 publications

Patterns of Psychopathology and Cognition in Sex Chromosome Aneuploidy

Patterns of Psychopathology and Cognition in Sex Chromosome Aneuploidy

Can the Child Behavior Checklist (CBCL) help characterize the types of psychopathologic conditions driving child psychiatry referrals?

DAT1 and Its Psychological Correlates in Children with Avoidant/Restrictive Food Intake Disorder: A Cross-Sectional Pilot Study

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