Clinical symptoms, comorbidities and complications in severe and non-severe patients with COVID-19

Wang, Zhufeng; Deng, Hongsheng; Ou, Changxing; Liang, Jingyi; Ying-zhi, Wang; Jiang, Mei; Li, Shiyue

doi:10.1097/md.0000000000023327

Cited by 65 publications

(51 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…After adjustment for other risk factors, we found only a weak association between cardiovascular disease and non-ICU hospitalization for COVID-19, and we found no association with ICU hospitalization. This result contradicts the findings of systematic reviews and meta-analyses [ 25 – 27 ]. Previous observational studies have shown conflicting results, perhaps in part due to differences in definition [ 5 , 7 , 8 ].…”

Section: Discussioncontrasting

confidence: 88%

Risk factors for COVID-19 diagnosis, hospitalization, and subsequent all-cause mortality in Sweden: a nationwide study

et al. 2021

View full text Add to dashboard Cite

We conducted a nationwide, registry-based study to investigate the importance of 34 potential risk factors for coronavirus disease 2019 (COVID-19) diagnosis, hospitalization (with or without intensive care unit [ICU] admission), and subsequent all-cause mortality. The study population comprised all COVID-19 cases confirmed in Sweden by mid-September 2020 (68,575 non-hospitalized, 2494 ICU hospitalized, and 13,589 non-ICU hospitalized) and 434,081 randomly sampled general-population controls. Older age was the strongest risk factor for hospitalization, although the odds of ICU hospitalization decreased after 60–69 years and, after controlling for other risk factors, the odds of non-ICU hospitalization showed no trend after 40–49 years. Residence in a long-term care facility was associated with non-ICU hospitalization. Male sex and the presence of at least one investigated comorbidity or prescription medication were associated with both ICU and non-ICU hospitalization. Three comorbidities associated with both ICU and non-ICU hospitalization were asthma, hypertension, and Down syndrome. History of cancer was not associated with COVID-19 hospitalization, but cancer in the past year was associated with non-ICU hospitalization, after controlling for other risk factors. Cardiovascular disease was weakly associated with non-ICU hospitalization for COVID-19, but not with ICU hospitalization, after adjustment for other risk factors. Excess mortality was observed in both hospitalized and non-hospitalized COVID-19 cases. These results confirm that severe COVID-19 is related to age, sex, and comorbidity in general. The study provides new evidence that hypertension, asthma, Down syndrome, and residence in a long-term care facility are associated with severe COVID-19.

show abstract

Section: Discussioncontrasting

confidence: 88%

Risk factors for COVID-19 diagnosis, hospitalization, and subsequent all-cause mortality in Sweden: a nationwide study

et al. 2021

View full text Add to dashboard Cite

show abstract

“…We did not capture symptoms such as fatigue, disturbances in taste and smell, and anxiety, widely reported in post-covid syndrome 24. Although we focused on outcomes after discharge for patients admitted to hospital for covid-19, a sizeable minority of individuals (38%) had not been discharged alive by the end of the study period, as reported globally 3435…”

Section: Discussionmentioning

confidence: 99%

Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study

Ayoubkhani

Khunti

Nafilyan

et al. 2021

BMJ

652

557

View full text Add to dashboard Cite

Objective To quantify rates of organ specific dysfunction in individuals with covid-19 after discharge from hospital compared with a matched control group from the general population. Design Retrospective cohort study. Setting NHS hospitals in England. Participants 47 780 individuals (mean age 65, 55% men) in hospital with covid-19 and discharged alive by 31 August 2020, exactly matched to controls from a pool of about 50 million people in England for personal and clinical characteristics from 10 years of electronic health records. Main outcome measures Rates of hospital readmission (or any admission for controls), all cause mortality, and diagnoses of respiratory, cardiovascular, metabolic, kidney, and liver diseases until 30 September 2020. Variations in rate ratios by age, sex, and ethnicity. Results Over a mean follow-up of 140 days, nearly a third of individuals who were discharged from hospital after acute covid-19 were readmitted (14 060 of 47 780) and more than 1 in 10 (5875) died after discharge, with these events occurring at rates four and eight times greater, respectively, than in the matched control group. Rates of respiratory disease (P<0.001), diabetes (P<0.001), and cardiovascular disease (P<0.001) were also significantly raised in patients with covid-19, with 770 (95% confidence interval 758 to 783), 127 (122 to 132), and 126 (121 to 131) diagnoses per 1000 person years, respectively. Rate ratios were greater for individuals aged less than 70 than for those aged 70 or older, and in ethnic minority groups compared with the white population, with the largest differences seen for respiratory disease (10.5 (95% confidence interval 9.7 to 11.4) for age less than 70 years v 4.6 (4.3 to 4.8) for age ≥70, and 11.4 (9.8 to 13.3) for non-white v 5.2 (5.0 to 5.5) for white individuals). Conclusions Individuals discharged from hospital after covid-19 had increased rates of multiorgan dysfunction compared with the expected risk in the general population. The increase in risk was not confined to the elderly and was not uniform across ethnicities. The diagnosis, treatment, and prevention of post-covid syndrome requires integrated rather than organ or disease specific approaches, and urgent research is needed to establish the risk factors.

show abstract

“…Hypertension, diabetes, and cardiovascular diseases were soon identified as common comorbidities in COVID-19 patients ( 1 , 2 ). The following studies revealed that hypertension is an important risk factor for adverse outcomes in COVID-19 patients ( 3 , 4 ). Initial studies reported hypertension as an independent predictor of hospitalization, an advanced stage of pneumonia, admission to the intensive care unit (ICU), and mortality in these patients ( 3 – 5 ).…”

Section: Introductionmentioning

confidence: 99%

Hypertension and COVID-19: Ongoing Controversies

Tadić

Saeed

Grassı

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Coronavirus disease 2019 (COVID-19) has become a worldwide pandemic responsible for millions of deaths around the world. Hypertension has been identified as one of the most common comorbidities and risk factors for severity and adverse outcome in these patients. Recent investigations have raised the question whether hypertension represents a predictor of outcome in COVID-19 patients independently of other common comorbidities such as diabetes, obesity, other cardiovascular diseases, chronic kidney, liver, and pulmonary diseases. However, the impact of chronic and newly diagnosed hypertension in COVID-19 patients has been insufficiently investigated. The same is true for the relationship between blood pressure levels and outcomes in COVID-19 patients. It seems that the long discussion about the impact of angiotensin-converting enzyme inhibitors (ACEI) and blockers of angiotensin I receptors (ARB) on severity and outcome in COVID-19 is approaching an end because the large number of original studies and meta-analyses discarded the initial findings about higher prevalence of ACEI/ARB use in patients with unfavorable outcomes. Nevertheless, there are many controversies in the relationship between hypertension and COVID-19. The aim of this review article is to provide a clinical overview of the currently available evidence regarding the predictive value of hypertension, the effect of blood pressure levels, the impact of previously known and newly diagnosed hypertension, and the effect of antihypertensive therapy on the severity and outcomes in COVID-19 patients.

show abstract

Clinical symptoms, comorbidities and complications in severe and non-severe patients with COVID-19

Cited by 65 publications

References 22 publications

Risk factors for COVID-19 diagnosis, hospitalization, and subsequent all-cause mortality in Sweden: a nationwide study

Risk factors for COVID-19 diagnosis, hospitalization, and subsequent all-cause mortality in Sweden: a nationwide study

Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study

Hypertension and COVID-19: Ongoing Controversies

Contact Info

Product

Resources

About