Clinical Theragnostic Relationship between Chemotherapeutic Resistance, and Sensitivity and miRNA Expressions in Head and Neck Cancers: A Systematic Review and Meta-Analysis Protocol

Abstract

Background: The microRNAs (miRNAs) are small noncoding single-stranded RNAs typically 19–25 nucleotides long and regulated by cellular and epigenetic factors. These miRNAs plays important part in several pathways necessary for cancer development, an altered miRNA expression can be oncogenic or tumor-suppressive. Recent experimental results on miRNA have illuminated a different perspective of the molecular pathogenesis of head and neck cancers. Regulation of miRNA can have a detrimental effect on the efficacy of chemotherapeutic drugs in both neoadjuvant and adjuvant settings. This miRNA-induced chemoresistance can influence the prognosis and survival rate. The focus of the study is on how regulations of various miRNA levels contribute to chemoresistance in head and neck cancer (HNC). Recent findings suggest that up or down-regulation of miRNAs may lead to resistance towards various chemotherapeutic drugs, which may influence the prognosis. Methods: Studies on miRNA-specific chemoresistance in HNC were collected through literary (bibliographic) databases, including SCOPUS, PubMed, Nature, Elsevier, etc., and were systematically reviewed following PRISMA-P guidelines (Preferred Reporting Items for Systematic Review and Meta-analysis Protocol). We evaluated various miRNAs, their up and downregulation, the effect of altered regulation on the patient’s prognosis, resistant cell lines, etc. The data evaluated will be represented in the form of a review and meta-analysis. Discussion: This meta-analysis aims to explore the miRNA-induced chemoresistance in HNC and thus to aid further researches on this topic. PROSPERO registration: CRD42018104657.

Clinical Investigation of Chemotherapeutic Resistance and miRNA Expressions in Head and Neck Cancers: A Thorough PRISMA Compliant Systematic Review and Comprehensive Meta-Analysis

“…This drug resistance tends to lead to rapid deterioration of the long-term prognosis of the patient [ 25 , 57 ]. This study aims to evaluate the potential role of miRNAs, which are one type among several types of small non-coding RNAs known to play a specific role in cancer progression, including the development of chemoresistance [ 25 , 33 ]. The regulation of chemoresistance specific miRNA is significant in the genesis of cancer as well as in the prognosis of the affected patient.…”

“…The study was conducted by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement [ 32 ] and was completed following a previously established protocol (PROSPERO registration number: CRD42018104657). The study protocol was already published elsewhere [ 33 ].…”

Chemotherapeutic Drug Resistance Associated with Differential miRNA Expression of miR-375 and miR-27 among Oral Cancer Cell Lines

“…Many reviews of miRNA expression among oral cancers have identified the potential utility of miRNA expression profiles as biomarkers and determinants for chemotherapy treatment [ 8 , 9 ]. This has led to the identification of specific miRNAs that modulate multiple tumorigenesis pathways, as well as resistance to chemotherapeutic agents—such as miR-21 and chemoresistance to Cisplatin therapy [ 10 , 11 , 12 ].…”

A Clinical Investigation on the Theragnostic Effect of MicroRNA Biomarkers for Survival Outcome in Cervical Cancer: A PRISMA-P Compliant Protocol for Systematic Review and Comprehensive Meta-Analysis

“…They seem to have a role in cervical carcinogenesis. Many articles covering the topic of CC discuss a single type of miRNA and its specific role [ 6 , 37 , 38 , 39 , 40 , 41 ]. They elaborate on how the respective miRNA causes resistance or sensitivity and the mechanism involved with decrease or increase in the chemoresistance of a specific anti-cancer drug.…”