Clinical thermometry, using the 27 MHz multi-electrode current-source interstitial hyperthermia system in brain tumours

Kaatee, R. S. J. P.; Nowak, Peter C. J. M.; Zee, Jacoba van der; Bree, Jacob de; Kanis, Bart P.; Crezee, J.; Levendag, Peter C.; Visser, A.G.

doi:10.1016/s0167-8140(01)00310-3

Cited by 5 publications

(6 citation statements)

References 18 publications

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“…In the present study, interstitial hyperthermia was combined with external radiotherapy only, in contrast with most other studies that combine interstitial hyperthermia with interstitial radiotherapy 10,11,14,22 . The advantage of the latter is that interstitial hyperthermia can be delivered through the brachytherapy catheters.…”

Section: Discussionmentioning

confidence: 89%

“…The improved thermal dose uniformity by the MECS-IHT system has been demonstrated in a clinical brain tumour study 22 and was further optimized in a phase I study for prostate cancer 23 . The MECS-IHT system employs applicators for both thermometry and energy deposition.…”

Section: The Mecs Interstitial Hyperthermia Systemmentioning

confidence: 99%

“…Temperature was measured and monitored continuously for each thermal probe. To prevent self-heating of the thermoprobes inside the electrodes, tissue temperatures were obtained 3-5 s after temporarily switching off the power, which was repeated every 30 s. The 5 s period is necessary to minimize the contribution of self-heating to the thermocouple readout 21,22 . The power output starts at a low level and was gradually increased in a period of $15 min, until the desired optimal steady state temperature was reached.…”

Section: Interstitial Hyperthermiamentioning

confidence: 99%

See 2 more Smart Citations

A feasibility study of interstitial hyperthermia plus external beam radiotherapy in glioblastoma multiforme using the multi electrode current source (MECS) system

Hulshof

Raaymakers

Lagendijk

et al. 2004

International Journal of Hyperthermia

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Section: Discussionmentioning

confidence: 89%

Section: The Mecs Interstitial Hyperthermia Systemmentioning

confidence: 99%

Section: Interstitial Hyperthermiamentioning

confidence: 99%

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A feasibility study of interstitial hyperthermia plus external beam radiotherapy in glioblastoma multiforme using the multi electrode current source (MECS) system

Hulshof

Raaymakers

Lagendijk

et al. 2004

International Journal of Hyperthermia

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“…They are mainly effective for controlling the maximum temperature in the implanted volume. The minimum temperature in the implant can be estimated by successively switching off the heating applicators (Kaatee et al 2001). Ideally the full 3D temperature distribution is non-invasively measured online, for instance by MR thermometry (Nelson and Tung 1987, Samulski et al 1992, Wlodarczyk et al 1998, De Zwart 2000.…”

Section: Introductionmentioning

confidence: 99%

Determination and validation of the actual 3D temperature distribution during interstitial hyperthermia of prostate carcinoma

Raaymakers¹,

Vulpen²,

Lagendijk³

et al. 2001

Phys. Med. Biol.

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To determine the thermal dose of a hyperthermia treatment, knowledge of the three-dimensional (3D) temperature distribution is mandatory. The aim of this paper is to validate an interstitial hyperthermia treatment planning system with which the full 3D temperature distribution can be obtained in individual patients. Within a phase I study, 12 patients with prostate cancer were treated with interstitial hyperthermia using our multi electrode current source interstitial hyperthermia treatment (MECS IHT) system. The temperature distribution was measured from within the heating devices and by additional thermometry. The perfusion level was estimated and the heating implant reconstructed. The steady-state temperature distribution was calculated using our interstitial hyperthermia treatment planning system. The simulated temperature distribution was validated by individually comparing the measured and simulated thermo-sensors, both for the thermometry integrated with the heating applicators and the additional thermometry. The entire procedure was also performed on a no-flow agar-agar phantom. It was shown that the calculated temperature distribution of an individual patient during MECS interstitial hyperthermia is very heterogeneous. The validation indicates that the calculated temperature elevations match the measurements within approximately 1 degrees C. Possible improvements are more precise reconstruction, incorporation of discrete vasculature and using a temperature-dependent, heterogeneous perfusion distribution. Further technical improvements of the MECS-IHT system may also result in better temperature calculations.

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“…Thermal prescriptive parameters can be expressed in terms of the cumulative equivalent number of minutes of heating to 43°C or thermal dose, t 43 , where and the dimensionless constant, C, is 0.5 above 43°C and 0.25 below 43°C (13, 14). Implanted thermocouple devices (15, 16), microwave tomography (17, 18), ultrasound (19), chemical probes combined with MRI (20, 21), and T1‐weighted MRI (22, 23) have been investigated as guidance options for thermal ablation. Insufficient guidance of thermal ablation may result in the persistence of residual viable tumor, generally along the dorsal border of the prostate, adjacent to the rectum (24–26).…”

mentioning

confidence: 99%

Effects of spatial and temporal resolution for MR image‐guided thermal ablation of prostate with transurethral ultrasound

Pisani

Ross

Diederich

et al. 2005

Magnetic Resonance Imaging

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Purpose:To describe approaches for determining optimal spatial and temporal resolutions for the proton resonance frequency shift method of quantitative magnetic resonance temperature imaging (MRTI) guidance of transurethral ultrasonic prostate ablation. Materials and Methods:Temperature distributions of two transurethral ultrasound applicators (90°sectored tubular and planar arrays) for canine prostate ablation were measured via MRTI during in vivo sonication, and agree well with two-dimensional finite difference model simulations at various spatial resolutions. Measured temperature distributions establish the relevant signalto-noise ratio (SNR) range for thermometry in an interventional MR scanner, and are reconstructed at different resolutions to compare resultant temperature measurements. Various temporal resolutions are calculated by averaging MRTI frames.Results: When noise is added to simulated temperature distributions for tubular and planar applicators, the minimum root mean squared (RMS) error is achieved by reconstructing to pixel sizes of 1.9 and 1.7 mm, respectively. In in vivo measurements, low spatial resolution MRTI data are shown to reduce the noise without significantly affecting thermal dose calculations. Temporal resolution of 0.66 frames/minute leads to measurement errors of more than 12°C during rapid heating. Conclusion:Optimizing MRTI pixel size entails balancing large pixel SNR gain with accuracy in representing underlying temperature distributions.

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Clinical thermometry, using the 27 MHz multi-electrode current-source interstitial hyperthermia system in brain tumours

Cited by 5 publications

References 18 publications

A feasibility study of interstitial hyperthermia plus external beam radiotherapy in glioblastoma multiforme using the multi electrode current source (MECS) system

A feasibility study of interstitial hyperthermia plus external beam radiotherapy in glioblastoma multiforme using the multi electrode current source (MECS) system

Determination and validation of the actual 3D temperature distribution during interstitial hyperthermia of prostate carcinoma

Effects of spatial and temporal resolution for MR image‐guided thermal ablation of prostate with transurethral ultrasound

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