Clinical tools that measure sitting posture, seated postural control or functional abilities in children with motor impairments: a systematic review

Field, Debra A; Livingstone, Roslyn

doi:10.1177/0269215513488122

Cited by 22 publications

(18 citation statements)

References 93 publications

(280 reference statements)

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“…1,25 We chose to use the SPCM and SAS because there are validity and reliability studies for these assessment tools, and they have face validity. 10,18,26 The results of this study showed that there is a very obvious need for postural support for seating in children with CP, since there was a significant difference in most In the present study, GMFCS Level 3, 4, and 5 children were included because the children in these levels require seating systems more, and it has been reported numerous times that as the level increases, their need for seating systems also increases. 11,17 It was surprising (because it contradicts with the literature) to see that there were differences among groups in terms of all SPCM values in both all children ungrouped as well as grouped, and paired comparisons showed no difference between seating groups except in Level 4 children.…”

Section: Discussionmentioning

confidence: 78%

Effects of different seating equipment on postural control and upper extremity function in children with cerebral palsy

Sahinoğlu

Coşkun

Bek

2017

Prosthetics &Amp; Orthotics International

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Although custom-made orthosis fabrication is time consuming, it is still recommended since it is custom made, easy to use, and low-cost. On the other hand, the adjustable seating system can be modified according to a patient's height and weight. Clinical relevance It was found that Gross Motor Function Classification System Level 4 children benefitted most from the seating support systems. It was presented that standard chair is sufficient in providing postural alignment. Both custom-made orthosis and adjustable seating system have pros and cons and the best solution for each will be dependent on a number of factors.

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Section: Discussionmentioning

confidence: 78%

Effects of different seating equipment on postural control and upper extremity function in children with cerebral palsy

Sahinoğlu

Coşkun

Bek

2017

Prosthetics &Amp; Orthotics International

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“…The reviews selected from this process included seating interventions [8], power mobility interventions [9], motor interventions [10], and treadmill training [11], as well as reviews of measurement tools suitable for children with CP [12], children using seating interventions [13], and children using power mobility [14]. The additional tools were only included based on agreement of the two reviewers if at least one study evidencing psychometric properties of these clinical tools and their use in measuring intervention outcomes with children with CP classified as GMFCS level IV or V was identified.…”

Section: Methodsmentioning

confidence: 99%

Measuring Outcomes for Children with Cerebral Palsy Who Use Gait Trainers

Livingstone

Paleg

2016

Technologies

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Gait trainers are walking devices that provide additional trunk and pelvic support. The primary population of children using gait trainers includes children with cerebral palsy (CP) functioning at Gross Motor Function Classification System (GMFCS) levels IV and V. A recent systematic review found that evidence supporting the effectiveness of gait trainer interventions for children was primarily descriptive and insufficient to draw firm conclusions. A major limitation identified was the lack of valid, sensitive and reliable tools for measuring change in body structure and function, activity and participation outcomes. Twelve different clinical tools were identified in the systematic review and in this paper we review and discuss the evidence supporting their reliability, validity and clinical utility for use with children using gait trainers. We also describe seven additional clinical measurement tools that may be useful with this intervention and population. The Pediatric Evaluation of Disability Inventory (PEDI) rated highest across all areas at this time. Individualized outcome measures, such as the Canadian Occupational Performance Measure (COPM) and Goal Attainment Scaling and measuring user satisfaction with tools, such as the Quebec User Evaluation of Satisfaction with assistive Technology, show potential for gait trainer outcomes research. Spatiotemporal measures appear to be less useful than functional measures with this intervention and population. All tools would benefit from further development for use with children with CP functioning at GMFCS levels IV and V.

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“…The represented clinical outputs include a continuous ACR-N score, joint space narrowing (JSN), and bone erosion score (BES), and are directly tied to reductions in the cellular infiltrate, rate of cartilage degradation, and rate of bone degradation, respectively. An expanded discussion of relevant modeling methodology for autoimmune disorders has been given previously [20]. …”

Section: Methodsmentioning

confidence: 99%

Alternate virtual populations elucidate the type I interferon signature predictive of the response to rituximab in rheumatoid arthritis

Schmidt¹,

Casey²,

Paterson³

et al. 2013

BMC Bioinformatics

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BackgroundMechanistic biosimulation can be used in drug development to form testable hypotheses, develop predictions of efficacy before clinical trial results are available, and elucidate clinical response to therapy. However, there is a lack of tools to simultaneously (1) calibrate the prevalence of mechanistically distinct, large sets of virtual patients so their simulated responses statistically match phenotypic variability reported in published clinical trial outcomes, and (2) explore alternate hypotheses of those prevalence weightings to reflect underlying uncertainty in population biology. Here, we report the development of an algorithm, MAPEL (Mechanistic Axes Population Ensemble Linkage), which utilizes a mechanistically-based weighting method to match clinical trial statistics. MAPEL is the first algorithm for developing weighted virtual populations based on biosimulation results that enables the rapid development of an ensemble of alternate virtual population hypotheses, each validated by a composite goodness-of-fit criterion.ResultsVirtual patient cohort mechanistic biosimulation results were successfully calibrated with an acceptable composite goodness-of-fit to clinical populations across multiple therapeutic interventions. The resulting virtual populations were employed to investigate the mechanistic underpinnings of variations in the response to rituximab. A comparison between virtual populations with a strong or weak American College of Rheumatology (ACR) score in response to rituximab suggested that interferon β (IFNβ) was an important mechanistic contributor to the disease state, a signature that has previously been identified though the underlying mechanisms remain unclear. Sensitivity analysis elucidated key anti-inflammatory properties of IFNβ that modulated the pathophysiologic state, consistent with the observed prognostic correlation of baseline type I interferon measurements with clinical response. Specifically, the effects of IFNβ on proliferation of fibroblast-like synoviocytes and interleukin-10 synthesis in macrophages each partially counteract reductions in synovial inflammation imparted by rituximab. A multianalyte biomarker panel predictive for virtual population therapeutic responses suggested population dependencies on B cell-dependent mediators as well as additional markers implicating fibroblast-like synoviocytes.ConclusionsThe results illustrate how the MAPEL algorithm can leverage knowledge of cellular and molecular function through biosimulation to propose clear mechanistic hypotheses for differences in clinical populations. Furthermore, MAPEL facilitates the development of multianalyte biomarkers prognostic of patient responses in silico.

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Clinical tools that measure sitting posture, seated postural control or functional abilities in children with motor impairments: a systematic review

Abstract: Although a number of tools are available, evidence supporting their use for seating interventions is limited, as is the evidence supporting the strength of their measurement properties. Few tools address participation, environmental factors or the child's and family's perspective.

Cited by 22 publications

References 93 publications

Effects of different seating equipment on postural control and upper extremity function in children with cerebral palsy

Effects of different seating equipment on postural control and upper extremity function in children with cerebral palsy

Measuring Outcomes for Children with Cerebral Palsy Who Use Gait Trainers

Alternate virtual populations elucidate the type I interferon signature predictive of the response to rituximab in rheumatoid arthritis

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