1905
DOI: 10.1097/00000441-190507000-00021
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Clinical Treatises on the Pathology and Therapy of Disorders of Metabolism and Nutrition

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Cited by 4 publications
(4 citation statements)
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“…We speculate that the capacity to store the byproducts of excess glucose by increasing the size of fat cells (manifested as obesity) might delay the onset of type 2 diabetes and its consequences in some individuals, thus explaining the so-called obesity paradox of lower mortality among people with obesity. This idea, although not new, fits better with the emerging evidence. If this speculation is correct, assessing the capacity to store such by-products at the individual level may be a useful step toward personalized medicine.…”
Section: Discussionmentioning
confidence: 66%
“…We speculate that the capacity to store the byproducts of excess glucose by increasing the size of fat cells (manifested as obesity) might delay the onset of type 2 diabetes and its consequences in some individuals, thus explaining the so-called obesity paradox of lower mortality among people with obesity. This idea, although not new, fits better with the emerging evidence. If this speculation is correct, assessing the capacity to store such by-products at the individual level may be a useful step toward personalized medicine.…”
Section: Discussionmentioning
confidence: 66%
“…In 1918, von Noorden W. and Volhard F. reported that a protein-reduced diet (Homburg diet) had suppressed uremic symptoms [18]. Since then, many studies have shown that a low-protein diet (LPD) reduced uremia symptoms, delayed the progression of renal failure, and extended life expectancy [19,20].…”
Section: Effects Of a Low-protein Diet On Ckdmentioning
confidence: 99%
“…The calorie-is-a-calorie idea dates to 1878 when Max Rubner established what he called the Isodynamic Law; in that law, the form of human energy intake is irrelevant to its effect on energy balance [41] . This belief was later applied to obesity by Carl Von Noorden's theory that common obesity was all about “calories-in-minus-calories-out.” [40] This theory has been well established and accepted since the 1900s but is now being challenged in the 21 st century [25] .…”
Section: The Great Sugar Debatementioning
confidence: 99%