Clinical trial of a lyophilized inactivated hepatitis A candidate vaccine in healthy adult volunteers

Iino, Shiro; Fujiyama, Shigetoshi; Horiuchi, Kensuke; Jyo, Keiichiro; Kuwabara, Y; S, Sato; Saika, Shizuko; Morita, Michio; Odoh, Koichi; Kuzuhara, Shoji; Watanabe, Hiroaki; Tanaka, Masahiko; Mizuno, Kyosuke

doi:10.1016/0264-410x(92)90371-p

Cited by 18 publications

(2 citation statements)

References 7 publications

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“…Recently an inactivated HAV vaccine became available in Japan (15,16) and other countries (17). Studies with the inactivated vaccine in a large number of human volunteers show that this vaccine is safe and induces high seroconversion rates against HAV with just two doses at a month interval.…”

Section: Discussionmentioning

confidence: 99%

The Latest Seroepidemiological Pattern of Hepatitis a in Japan

Kiyohara

Satoh

Yamamoto

et al. 1997

JJMSB

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SUMMARY:Age-specific prevalence of anti-hepatitis A virus antibody (anti-HAV) was surveyed with 2,708 sera collected in 1994 in various areas of Japan. By age-group analyses, we found strong association of anti-HAV antibody with higher. age group. The prevalence ratios of antibody in the groups of 30-34, 35-39, 40-44, 45-49, 50-54, 55-59, 60-64 and 65 years or older were 0, 4.2, 22.0, 44.8, 57.6, 76.4, 84.5 and 91.4%, respectively.Geometric mean titers of anti-HAV antibody in the positive age groups were approximately 6,000 mIU/ml. The seropositives among older population were ascribed to the infections more than 40 years ago and the high anti-HAV titers have been maintained since that time. In Japan, people younger than 40 years of age are extremely risky to HAV infection, since 99% have no antibody. Those in forties are also risky since two-thirds of them are seronegative. In Japan, an inactivated vaccine was licensed in 1994. Vaccination may be recommended for such high-risk groups as travelers going to endemic areas, patients who have received blood product medication and child-care staffs.

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Section: Discussionmentioning

confidence: 99%

The Latest Seroepidemiological Pattern of Hepatitis a in Japan

Kiyohara

Satoh

Yamamoto

et al. 1997

JJMSB

View full text Add to dashboard Cite

show abstract

“…Its safety and high rate of antibody acquisition against HAV have been confirmed in vaccinated individuals. 27 Furthermore, Sagliocca et al 28 have reported that HAV vaccination is effective in the prevention of secondary infection associated with HAV. Acute hepatitis A may occur in Japanese who travel to highly endemic areas, and vaccination against HAV is recommended.…”

Section: Discussionmentioning

confidence: 98%