Clinical trial of the effects of coenzyme q10 supplementation on biomarkers of inflammation and oxidative stress in diabetic hemodialysis patients

Fallah, Maryam; Askari, Gholamreza; Soleimani, Alireza; Feizi, Awat; Asemi, Zatollah

doi:10.4103/ijpvm.ijpvm_418_18

Cited by 29 publications

(18 citation statements)

References 39 publications

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“…These findings were similar to those of Maheshwari et al [ 43 ], in that CoQ10 administration significantly improved the activities of antioxidative enzymes in a rat model of diabetic nephropathy. The efficacy of CoQ10 treatment was also reported in clinical trials [ 44 , 45 , 46 ]. In addition, as a marker of lipid peroxidation, the MDA levels in CKD patients were significantly decreased following CoQ10 treatment according to a systematic review published in 2018 [ 47 ].…”

Section: Discussionmentioning

confidence: 82%

Does Coenzyme Q10 Supplementation Improve Testicular Function and Spermatogenesis in Male Mice with Chronic Kidney Disease?

Tsao

Hsu

Tseng

et al. 2021

Biology

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The aim of the study was to examine the potential effects of coenzyme Q10 (CoQ10) on reproductive function in a chronic kidney disease (CKD) mouse model. Nine-week-old mice were randomly assigned to two groups: sham surgery (n = 18) and CKD surgery (n = 18). After surgery, the study groups received CoQ10 (10 mg/kg body weight dissolved in corn oil by oral gavage) or corn oil as a vehicle daily for 8 weeks. The groups that underwent 5/6 nephrectomy developed significant elevations of serum BUN and creatinine levels. The CoQ10 treatment significantly increased the serum and testicular CoQ10 levels and alleviated the poor semen quality from incomplete spermatogenesis. The testosterone concentration, in addition to the protein expression of enzymes related to testosterone biosynthesis, was also elevated, and the CKD-induced decrease in antioxidant activity in the testes was significantly ameliorated. The results suggest that CoQ10 could act against CKD-induced testicular dysfunction through improvements in the sperm function, testicular morphology, testosterone levels and related biosynthesis pathways, in addition to antioxidant activity.

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Section: Discussionmentioning

confidence: 82%

Does Coenzyme Q10 Supplementation Improve Testicular Function and Spermatogenesis in Male Mice with Chronic Kidney Disease?

Tsao

Hsu

Tseng

et al. 2021

Biology

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“…However, during this reaction, ascorbate and NADH becomes oxidized giving dehydroascorbate (DHA) and NAD + , respectively. QQ is toxic in the absence of GSH because GSH can produce reversible GSQ adducts including 6-GSQ and 8-GSQ [293,296]. Therefore, administration of ascorbate supplementation is suggested during QC ingestion at a high dose level.…”

Section: Structurementioning

confidence: 99%

Quercetin attenuates neurotoxicity induced by iron oxide nanoparticles

et al. 2021

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Iron oxide nanoparticles (IONPs) have been proposed as targeted carriers to deliver therapeutic molecules in the central nervous system (CNS). However, IONPs may damage neural tissue via free iron accumulation, protein aggregation, and oxidative stress. Neuroprotective effects of quercetin (QC) have been proven due to its antioxidant and anti-inflammatory properties. However, poor solubility and low bioavailability of QC have also led researchers to make various QC-involved nanoparticles to overcome these limitations. We wondered how high doses or prolonged treatment with quercetin conjugated superparamagnetic iron oxide nanoparticles (QCSPIONs) could improve cognitive dysfunction and promote neurogenesis without any toxicity. It can be explained that the QC inhibits protein aggregation and acts against iron overload via iron-chelating activity, iron homeostasis genes regulation, radical scavenging, and attenuation of Fenton/Haber–Weiss reaction. In this review, first, we present brain iron homeostasis, molecular mechanisms of iron overload that induced neurotoxicity, and the role of iron in dementia-associated diseases. Then by providing evidence of IONPs neurotoxicity, we discuss how QC neutralizes IONPs neurotoxicity, and finally, we make a brief comparison between QC and conventional iron chelators. In this review, we highlight that QC as supplementation and especially in conjugated form reduces iron oxide nanoparticles neurotoxicity in clinical application.

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“…However, various fresh, frozen, and dried fruits should also be taken into account (e.g., pomegranate and tropical fruits) [ 9 , 10 , 11 ]. In addition, many people take polyphenols in the form of dietary supplements that contain either purified polyphenols (e.g., quercetin [ 12 ] and resveratrol [ 13 ]) or extracts from raw materials which are rich in these ingredients (such as extracts from tea, red wine, grapes, blueberries, pomegranate, etc.) [ 11 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Possible Side Effects of Polyphenols and Their Interactions with Medicines

Duda-Chodak

Tarko

2023

Molecules

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Polyphenols are an important component of plant-derived food with a wide spectrum of beneficial effects on human health. For many years, they have aroused great interest, especially due to their antioxidant properties, which are used in the prevention and treatment of many diseases. Unfortunately, as with any chemical substance, depending on the conditions, dose, and interactions with the environment, it is possible for polyphenols to also exert harmful effects. This review presents a comprehensive current state of the knowledge on the negative impact of polyphenols on human health, describing the possible side effects of polyphenol intake, especially in the form of supplements. The review begins with a brief overview of the physiological role of polyphenols and their potential use in disease prevention, followed by the harmful effects of polyphenols which are exerted in particular situations. The individual chapters discuss the consequences of polyphenols’ ability to block iron uptake, which in some subpopulations can be harmful, as well as the possible inhibition of digestive enzymes, inhibition of intestinal microbiota, interactions of polyphenolic compounds with drugs, and impact on hormonal balance. Finally, the prooxidative activity of polyphenols as well as their mutagenic, carcinogenic, and genotoxic effects are presented. According to the authors, there is a need to raise public awareness about the possible side effects of polyphenols supplementation, especially in the case of vulnerable subpopulations.

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Clinical trial of the effects of coenzyme q10 supplementation on biomarkers of inflammation and oxidative stress in diabetic hemodialysis patients

Cited by 29 publications

References 39 publications

Does Coenzyme Q10 Supplementation Improve Testicular Function and Spermatogenesis in Male Mice with Chronic Kidney Disease?

Does Coenzyme Q10 Supplementation Improve Testicular Function and Spermatogenesis in Male Mice with Chronic Kidney Disease?

Quercetin attenuates neurotoxicity induced by iron oxide nanoparticles

Possible Side Effects of Polyphenols and Their Interactions with Medicines

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